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Proof of concept for a single-dose Group B Streptococcus vaccine based on capsular polysaccharide conjugated to Qβ virus-like particles
A maternal vaccine to protect neonates against Group B Streptococcus invasive infection is an unmet medical need. Such a vaccine should ideally be...
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Calibration of a serum reference standard for Group B streptococcal polysaccharide conjugate vaccine development using surface plasmon resonance
Group B streptococcus (GBS) is a leading cause of neonatal morbidity and mortality worldwide. Development of a maternal vaccine to protect newborns...
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Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults
Pneumococcal infections cause serious illness and death among older adults. The capsular polysaccharide vaccine PPSV23 and conjugated alternative...
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Structural and biological insights into Klebsiella pneumoniae surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use
BackgroundK1 capsular polysaccharide (CPS)-associated Klebsiella pneumoniae is the primary cause of pyogenic liver abscesses (PLA) in Asia. Patients...
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Significant shifts in the distribution of vaccine capsular polysaccharide types and rates of antimicrobial resistance of perinatal group B streptococci within the last decade in St. Petersburg, Russia
Evaluation of circulating group B streptococcus (GBS) strains is important to assess the potential effects of GBS prevention strategies in a certain...
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Polysaccharides of Fungal Origin
Cryptococcus neoformans was first isolated as a human pathogen in the 1890s. Subsequent study has shown that the polysaccharide capsule of C....
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A case of neck abscess caused by rare hypervirulent Klebsiella pneumoniae, capsular type K20 and sequence type 420
BackgroundThis case report describes a neck abscess caused by a strain of Hypervirulent Klebsiella pneumoniae in a middle aged man with diabetes...
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Prevalence of pathogenic Klebsiella pneumoniae based on PCR capsular ty** harbouring carbapenemases encoding genes in Uganda tertiary hospitals
BackgroundKlebsiella pneumoniae is an opportunistic pathogen that has been implicated as one of commonest cause of hospital and community acquired...
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Biosynthesis of Bacterial Polysaccharides
The present chapter is devoted to biosynthesis pathways of various bacterial surface polysaccharides, including slime exopolysaccharides and capsular...
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Klebsiella pneumoniae Virulence Factors and Biofilm Components: Synthesis, Structure, Function, and Inhibitors
Klebsiella pneumoniae is a Gram-negative pathogen capable of causing a diverse array of infections in humans. It belongs to the group of ESKAPE...
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Investigation of bioluminescence-based assays for determination of kinetic parameters for the bifunctional Neisseria meningitidis serogroup W capsule polymerase
ObjectiveNeisseria meningitidis is a Gram-negative bacterium that causes meningitis. N. meningitidis serogroup W ( Nm W) capsule polymerase...
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Antibody enhanced HPLC for serotype-specific quantitation of polysaccharides in pneumococcal conjugate vaccine
Bacterial infection remains as one of the major healthcare issues, despite significant scientific and medical progress in this field. Infection by Stre...
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Carbohydrate Specificity and Isotypes of Monoclonal and Polyclonal Antibodies to Conjugated Tetrasaccharide, a Synthetic Analogue of Repeating Unit of Capsular Polysaccharide of Streptococcus Pneumoniae Serotype 14
We studied carbohydrate specificity and isotypes of antibodies to BSA-conjugated tetrasaccharide, a repeating unit of the capsular polysaccharide of St...
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Polysaccharides of Fungal Origin
Cryptococcus neoformans was first isolated as a human pathogen in the 1890s. Subsequent study has shown that the polysaccharide capsule of C....
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Lung abscess due to Neisseria meningitidis serogroup X—unexpected virulence of a commensal resulting from putative serogroup B capsular switching
To report the first case of a lung abscess caused by Neisseria meningitidis (Nm) and to genetically characterize the rare underlying capsule...
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Outer Membrane Vesicle Vaccine Platforms
Outer membrane vesicles (OMVs) are spontaneously released by many gram-negative bacteria during their growth and constitute an important virulence...
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Pneumococcal capsule blocks protection by immunization with conserved surface proteins
Vaccines targeting Streptococcus pneumoniae (Spn) are limited by dependence on capsular polysaccharide and its serotype diversity. More broadly-based...
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Clinical and molecular epidemiology of invasive group B Streptococcus infections in adults in a referral center in Korea
Invasive group B Streptococcus (GBS) infections are increasing among adults with underlying health conditions; however, clinical manifestations and...
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Biosynthesis of Bacterial Polysaccharides
The present chapter is devoted to biosynthesis pathways of various bacterial surface polysaccharides, including slime exopolysaccharides and capsular...