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A genome-wide association study identifies candidate genes for sleep disturbances in depressed individuals
ObjectiveThis study aimed to identify candidate loci and genes related to sleep disturbances in depressed individuals and clarify the co-occurrence...
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Conditional transcriptome-wide association study for fine-map** candidate causal genes
Transcriptome-wide association studies (TWASs) aim to integrate genome-wide association studies with expression-map** studies to identify genes...
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Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on...
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Identifying Novel Drug Targets for Epilepsy Through a Brain Transcriptome-Wide Association Study and Protein-Wide Association Study with Chemical-Gene-Interaction Analysis
Epilepsy is a severe neurological condition affecting 50–65 million individuals worldwide that can lead to brain damage. Nevertheless, the etiology...
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Harnessing large language models (LLMs) for candidate gene prioritization and selection
BackgroundFeature selection is a critical step for translating advances afforded by systems-scale molecular profiling into actionable clinical...
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Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease
Survival from ovarian cancer depends on the resection status after primary surgery. We performed genome-wide association analyses for resection...
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Gene-based association study reveals a distinct female genetic signal in primary hypertension
Hypertension is a polygenic disease that affects over 1.2 billion adults aged 30–79 worldwide. It is a major risk factor for renal, cerebrovascular,...
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Association of Renin–Angiotensin Pathway Gene Polymorphisms with COVID-19 Susceptibility and Severity in Moroccans: A Case–Control Study
Infection by the recent SARS-CoV-2 virus causes the COVID-19 disease with variable clinical manifestations ranging from asymptomatic or mild...
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Sex bias in celiac disease: XWAS and monocyte eQTLs in women identify TMEM187 as a functional candidate gene
BackgroundCeliac disease (CeD) is an immune-mediated disorder that develops in genetically predisposed individuals upon gluten consumption. HLA risk...
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A genome-wide association analysis of loss of ambulation in dystrophinopathy patients suggests multiple candidate modifiers of disease severity
The major determinant of disease severity in Duchenne muscular dystrophy (DMD) or milder Becker muscular dystrophy (BMD) is whether the dystrophin...
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Study on the association between adverse drug reactions to opioids and gene polymorphisms: a case-case–control study
ObjectiveAdverse drug reactions (ADRs) caused by opioid drugs show individual differences. Our objective was to explore the association between gene...
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Genome-Wide Association Study: Analysis of Association of Polymorphic Loci in 4p15.2 and 20q13.31 Regions with Paranoid Schizophrenia
AbstractOver fifteen years, genome-wide association studies (GWAS) have identified several million polymorphic risk markers for schizophrenia,...
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Gene based markers improve precision of genome-wide association studies and accuracy of genomic predictions in rice breeding
It is hypothesized that the genome-wide genic markers may increase the prediction accuracy of genomic selection for quantitative traits. To test this...
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Burden re-analysis of neurodevelopmental disorder cohorts for prioritization of candidate genes
This study aimed to uncover novel genes associated with neurodevelopmental disorders (NDD) by leveraging recent large-scale de novo burden analysis...
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Identifying Candidate Genes Associated with Sporadic Amyotrophic Lateral Sclerosis via Integrative Analysis of Transcriptome-Wide Association Study and Messenger RNA Expression Profile
Amyotrophic lateral sclerosis, a fatal neurodegeneration disease affecting motor neurons in the brain and spinal cord, is difficult to diagnose and...
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Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study
BackgroundCerebral stroke (CS) is the leading cause of death in China, and a complex disease caused by both alterable risk factors and genetic...
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Identification of RAD17 as a candidate cancer predisposition gene in families with histories of pancreatic and breast cancers
BackgroundAmong the 10% of pancreatic cancers that occur in a familial context, around a third carry a pathogenic variant in a cancer predisposition...
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Association between arsenic (+3 oxidation state) methyltransferase gene polymorphisms and arsenic methylation capacity in rural residents of northern China: a cross-sectional study
Arsenic is a toxic metal-like element. The toxic reaction of the body to arsenic is related to the ability of arsenic methylation metabolism. As the...
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Bioinformatics screening of colorectal-cancer causing molecular signatures through gene expression profiles to discover therapeutic targets and candidate agents
BackgroundDetection of appropriate receptor proteins and drug agents are equally important in the case of drug discovery and development for any...
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Identification and functional characterization of BICD2 as a candidate disease gene in an consanguineous family with dilated cardiomyopathy
BackgroundFamilial dilated cardiomyopathy (DCM) is a genetic cardiomyopathy that is associated with reduced left ventricle function or systolic...
