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Cancer and Hypercalcemia
Alterations of calcium homeostasis leading to hypercalcemia can occur at three different levels: the bone (increased osteoclast activity), kidney...
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Effects of Modeling of Hypercalcemia and β-Amyloid on Cultured Hippocampal Neurons of Rats
Alzheimer’s disease (AD) is the most common type of dementia; it is characterized by accumulations of amyloid (Aβ) plaques and neurofibrillary...
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Bone Metastases: Systemic Regulation and Impact on Host
Advanced cancers frequently metastasize to bone and disrupt normal bone remodeling to cause bone destruction. Bone metastases are incurable and...
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Bone-Muscle Crosstalk in Advanced Cancer and Chemotherapy
Advanced cancers metastasize to distant sites and bone is a common site for metastases from breast, lung, and prostate cancers. Breast and lung...
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Engineering and Studying Syngeneic Animal Tumors and Large Animal Endogenous Tumor Models
In this review, we discussed mice model and canine model which are used to study different types of cancer. Mice models are the most commonly used...
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Muscle and fat composition in patients with newly diagnosed multiple myeloma
Measures of muscle and adipose tissue mass have been associated with outcomes in several malignancies, but studies in multiple myeloma (MM) are...
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Hypercalcemia of Malignancy
This chapter discusses hypercalcemia of malignancy which is the commonest biochemical complication of cancer and recognized as a medical emergency....
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Water and Electrolytes Disorders in Oncology
Introduction: water and electrolyte disorders are frequently found in oncologic patients since they are usually exposed to diverse symptoms,...
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Engineering and studying syngeneic animal tumors and Large animal endogenous tumor models
In this review, we discussed mice model and canine model which are used to study different types of cancer. Mice models are the most commonly used...
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Pharmacology of Mammalian Na+-Dependent Transporters of Inorganic Phosphate
Inorganic phosphate (Pi) is an essential component of many biologically important molecules such as DNA, RNA, ATP, phospholipids, or apatite. It is...
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Bone-matrix mineralization dampens integrin-mediated mechanosignalling and metastatic progression in breast cancer
In patients with breast cancer, lower bone mineral density increases the risk of bone metastasis. Although the relationship between bone-matrix...
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Role of Dietary Antioxidants in Chemoprevention of Nitrosamines-Induced Carcinogenesis
Cancer is a persistent public health challenge globally, and it is now one of the leading causes of mortality even in developed countries....
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Procoxacin bidirectionally inhibits osteoblastic and osteoclastic activity in bone and suppresses bone metastasis of prostate cancer
BackgroundBone is the most common site of metastasis of prostate cancer (PCa). PCa invasion leads to a disruption of osteogenic-osteolytic balance...
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Characterization of Cancer-Induced Nociception in a Murine Model of Breast Carcinoma
Severe and poorly treated pain often accompanies breast cancer. Thus, novel mechanisms involved in breast cancer-induced pain should be investigated....
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Hyaluronan in the Extracellular Matrix of Hematological and Solid Tumors. Its Biological Effects
Tumors are most frequently induced by environmental factors with oncogenic potential. Beside tumor cells, cancer tissue contains several nonmalignant...
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Constipation, Diarrhea, and Intestinal Obstruction in Palliative Care
The symptoms of bowel function, including constipation, diarrhea, and bowel obstructions, are problems that commonly affect palliative care patients....
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The Management of Neurological Symptoms in Palliative Care
Neurological disease is a major cause of disability and death across the world. There is increasing evidence that palliative care is effective in...
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Does the use of bisphosphonates during pregnancy affect fetal outcomes? A systematic review
PurposeThis systematic review aimed to determine the effects of maternal exposure to bisphosphonates (BPs) during pregnancy on neonatal outcomes. It...
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Immunobiology of Lung Cancer
Lung cancer still has a bad prognosis, despite a reducing incidence. The absence of early detection and the recent advancements in targeted cancer...
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An Updated Focus on Immune Checkpoint Inhibitors and Tubulointerstitial Nephritis
One of the most relevant achievements in oncological research is represented by the development of a new category of anticancer drugs, the immune...