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Detection and quantitative analysis of tumor-associated tertiary lymphoid structures
Tumor-associated tertiary lymphoid structures (TLSs) are ectopic lymphoid formations within tumor tissue, with mainly B and T cell populations...
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Density and maturity of peritumoral tertiary lymphoid structures in oesophageal squamous cell carcinoma predicts patient survival and response to immune checkpoint inhibitors
BackgroundTertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates in non-lymphoid tissues, which are associated with improved prognosis...
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Single-cell sequencing reveals the heterogeneity of B cells and tertiary lymphoid structures in muscle-invasive bladder cancer
BackgroundMuscle-invasive bladder cancer (MIBC) is a highly aggressive disease with a poor prognosis. B cells are crucial factors in tumor...
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The radiological characteristics, tertiary lymphoid structures, and survival status associated with EGFR mutation in patients with subsolid nodules like stage I-II LUAD.
BackgroundEpidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) recommended for the patients with subsolid nodule in early lung...
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Tertiary lymphoid structures as unique constructions associated with the organization, education, and function of tumor-infiltrating immunocytes
Tertiary lymphoid structures (TLSs) are formations at sites with persistent inflammatory stimulation, including tumors. These ectopic lymphoid organs...
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Synergistic induction of tertiary lymphoid structures by chemoimmunotherapy in bladder cancer
BackgroundA substantial number of patients with bladder cancer fail to benefit from immune checkpoint inhibitors (ICIs). We aim to investigate...
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Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application
Tertiary lymphoid structures (TLS) are clusters of immune cells that resemble and function similarly to secondary lymphoid organs (SLOs). While TLS...
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Tertiary lymphoid structures associate with improved survival in early oral tongue cancer
BackgroundThe clinical significance of tertiary lymphoid structures (TLSs) is not well-documented in early oral tongue squamous cell carcinoma...
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Tertiary lymphoid structures correlate with enhancement of antitumor immunity in esophageal squamous cell carcinoma
BackgroundTertiary lymphoid structures (TLSs) are associated with a favorable prognosis in several cancers. However, the correlation between TLSs and...
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Prognostic value of tertiary lymphoid structures (TLS) in digestive system cancers: a systematic review and meta-analysis
BackgroundExisting literature suggests that tertiary lymphatic structure (TLS) is associated with the progression of cancer. However, the prognostic...
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HLA-A+ tertiary lymphoid structures with reactivated tumor infiltrating lymphocytes are associated with a positive immunotherapy response in esophageal squamous cell carcinoma
BackgroundImmune checkpoint blockade (ICB) therapy provides remarkable clinical benefits for multiple cancer types. However, the overall response...
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Prognostic and clinicopathological significance of tertiary lymphoid structure in non-small cell lung cancer: a systematic review and meta-analysis
BackgroundNon-small cell lung cancer (NSCLC) is the primary reason for cancer-related deaths globally. Tertiary lymphoid structure (TLS) is an...
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Clinical relevance of tertiary lymphoid structures in esophageal squamous cell carcinoma
BackgroundTertiary lymphoid structures (TLSs) have been reported to be involved in immune responses in many carcinomas. This study investigated the...
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Tumor-Associated Tertiary Lymphoid Structures: A Cancer Biomarker and a Target for Next-generation Immunotherapy
The different forms of lymphoid organization that coexist in our bodies appeared at distinct time points during the evolution of the animal kingdom....
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TCL1A-expressing B cells are critical for tertiary lymphoid structure formation and the prognosis of oral squamous cell carcinoma
BackgroundOral squamous cell carcinoma (OSCC) is a malignant tumor with a poor prognosis. Traditional treatments have limited effectiveness....
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Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort
Immune checkpoint inhibitors (ICIs) show limited clinical activity in patients with advanced soft-tissue sarcomas (STSs). Retrospective analysis...
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Prognostic impact of tertiary lymphoid structures in breast cancer prognosis: a systematic review and meta-analysis
BackgroundTertiary lymphoid structures (TLSs), organizationally resemble lymph nodes, are frequently present in breast cancer (BCa). It is usually,...
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HCMV IE1/IE1mut Therapeutic Vaccine Induces Tumor Regression via Intratumoral Tertiary Lymphoid Structure Formation and Peripheral Immunity Activation in Glioblastoma Multiforme
Glioblastoma multiforme (GBM), a highly malignant invasive brain tumor, is associated with poor prognosis and survival and lacks an effective cure....
