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Polygenic risk scores, radiation treatment exposures and subsequent cancer risk in childhood cancer survivors
Survivors of childhood cancer are at increased risk for subsequent cancers attributable to the late effects of radiotherapy and other treatment...
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Increased risk of contralateral breast cancer for BRCA1/2 wild-type, high-risk Korean breast cancer patients: a retrospective cohort study
BackgroundThis study aimed to investigate the contralateral breast cancer (CBC) recurrence rate in Korean breast cancer patients according to their BRCA1/2...
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Family History and the Risk of Breast and Gastric Cancer
Epidemiologists have used family history, usually of first-degree relatives, as a marker for genetic risk, knowing that family history reflects the...
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Prostate Cancer: Epidemiology, Etiology, Pathogenesis, and Risk Factors
Prostate cancer is today the most common cancer in men in developed countries. The very high incidence of prostate cancer in the developed world...
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Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across...
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Impact of individual level uncertainty of lung cancer polygenic risk score (PRS) on risk stratification
BackgroundAlthough polygenic risk score (PRS) has emerged as a promising tool for predicting cancer risk from genome-wide association studies (GWAS),...
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Fracture risk among patients with cancer compared to individuals without cancer: a population-based study
BackgroundPatients with cancer may be at increased risk of osteoporosis and fracture; however, gaps exist in the existing literature and the...
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Genetic risk assessment of lethal prostate cancer using polygenic risk score and hereditary cancer susceptibility genes
BackgroundThe genetic risk of aggressive prostate cancer (PCa) is hard to be assessed due to the lack of aggressiveness-related single-nucleotide...
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Risk Factors of Oral Cancer: Identification and Mechanism of Prevention
Background: Oral cancer is a serious public health problem. Unfortunately, most cases are diagnosed in advanced stages and consequently have a poor...
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Different operationalizations of the 2018 WCRF/AICR cancer prevention recommendations and risk of cancer
BackgroundThe standardized scoring system assessing adherence to the 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research...
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Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk
BackgroundMenopausal hormone therapy (MHT), a common treatment to relieve symptoms of menopause, is associated with a lower risk of colorectal cancer...
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Risk-based lung cancer screening performance in a universal healthcare setting
Globally, lung cancer is the leading cause of cancer death. Previous trials demonstrated that low-dose computed tomography lung cancer screening of...
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Subsequent female breast cancer risk associated with anthracycline chemotherapy for childhood cancer
Anthracycline-based chemotherapy is associated with increased subsequent breast cancer (SBC) risk in female childhood cancer survivors, but the...
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Cancer risk in individuals with polydactyly: a Swedish population-based cohort study
BackgroundPolydactyly is a feature of several cancer predisposition syndromes (CPS), however, cancer risk in individuals with polydactyly is largely...
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Introduction on Cancer Modifiable Risk Factors and Prevention
Disregarding its various types, cancer is known as one of the most common causes of death worldwide. In 2020, around ten million patients died due to...
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Clinical features of prostate cancer by polygenic risk score
Genome-wide association studies have identified more than 290 single nucleotide variants (SNVs) associated with prostate cancer. These SNVs can be...
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The experience of receiving a letter from a cancer genetics clinic about risk for hereditary cancer
Direct contact may be an option for supporting disclosure in families with hereditary cancer risk. In this qualitative interview study, we explored...
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The Italian registry of families at risk for pancreatic cancer (IRFARPC): implementation and evolution of a national program for pancreatic cancer surveillance in high-risk individuals
Screening programs for early detection and treatment of pancreatic cancer (PC) and its precursor lesions are increasingly implemented worldwide to...
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Association of diabetes risk reduction diet with renal cancer risk in 101,755 participants: a prospective study
BackgroundThere is little prospective evidence exists about whether adherence to a diabetes risk reduction diet (DRRD) is related to a significant...
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Genome-wide polygenic risk scores for colorectal cancer have implications for risk-based screening
BackgroundHereditary factors, including single genetic variants and family history, can be used for targeting colorectal cancer (CRC) screening, but...
