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Functional expression of mitochondrial KCa3.1 channels in non-small cell lung cancer cells
Lung cancer is one of the leading causes of cancer-related deaths worldwide. The Ca 2+ -activated K + channel K Ca 3.1 contributes to the progression of...
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Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels
Small- and intermediate-conductance Ca 2+ -activated K + (K Ca 2.x/K Ca 3.1 also called SK/IK) channels are gated exclusively by intracellular Ca 2+ . The Ca 2+ ...
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Neuroprotective Effects of Ferrostatin and Necrostatin Against Entorhinal Amyloidopathy-Induced Electrophysiological Alterations Mediated by voltage-gated Ca2+ Channels in the Dentate Gyrus Granular Cells
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is the main form of dementia. Abnormal deposition of amyloid-beta (Aβ)...
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Enhancement of airway ciliary beating mediated via voltage-gated Ca2+ channels/α7-nicotinic receptors in mice
Acetylcholine (ACh), which activates muscarinic ACh receptors (mAChRs) and nicotinic ACh receptors (nAChRs), enhances airway ciliary beating by...
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CaVβ-subunit dependence of forward and reverse trafficking of CaV1.2 calcium channels
Auxiliary Ca V β subunits interact with the pore forming Ca V α 1 subunit to promote the plasma membrane expression of high voltage-activated calcium...
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Voltage-dependent CaV3.2 and CaV2.2 channels in nociceptive pathways
Noxious stimuli like cold, heat, pH change, tissue damage, and inflammation depolarize a membrane of peripheral endings of specialized nociceptive...
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TRPC Channels Activated by G Protein-Coupled Receptors Drive Ca2+ Dysregulation Leading to Secondary Brain Injury in the Mouse Model
Canonical transient receptor potential (TRPC) non-selective cation channels, particularly those assembled with TRPC3, TRPC6, and TRPC7 subunits, are...
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Aggressive migration in acidic pH of a glioblastoma cancer stem cell line in vitro is independent of ASIC and KCa3.1 ion channels, but involves phosphoinositide 3-kinase
The microenvironment of proliferative and aggressive tumours, such as the brain tumour glioblastoma multiforme (GBM), is often acidic, hypoxic, and...
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Differential activation of Ca2+ influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration
Stem cells have indefinite self-renewable capability; however, factors that modulate their pluripotency/function are not fully identified. Here we...
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L-cysteine modulates visceral nociception mediated by the CaV2.3 R-type calcium channels
Ca V 2.3 channels are subthreshold voltage-gated calcium channels that play crucial roles in neurotransmitter release and regulation of membrane...
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Functional expression of the proton sensors ASIC1a, TMEM206, and OGR1 together with BKCa channels is associated with cell volume changes and cell death under strongly acidic conditions in DAOY medulloblastoma cells
Fast growing solid tumors are frequently surrounded by an acidic microenvironment. Tumor cells employ a variety of mechanisms to survive and...
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Cavβ surface charged residues contribute to the regulation of neuronal calcium channels
Voltage-gated calcium channels are essential regulators of brain function where they support depolarization-induced calcium entry into neurons. They...
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Regulation of CaV3.2 channels by the receptor for activated C kinase 1 (Rack-1)
This study describes the interaction between Ca V 3.2 calcium channels and the receptor for activated C kinase 1 (Rack-1), a scaffold protein which has...
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Effects of butyrate− on ruminal Ca2+ transport: evidence for the involvement of apically expressed TRPV3 and TRPV4 channels
The ruminal epithelium absorbs large quantities of NH 4 + and Ca 2+ . A role for TRPV3 has emerged, but data on TRPV4 are lacking. Furthermore,...
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Low voltage-activated channels in rat pulmonary vein cardiomyocytes: coexistence of a non-selective cationic channel and of T-type Ca channels
In rat pulmonary vein (PV) cardiomyocytes (CM), norepinephrine (NE) induces an automatic activity consisting of bursts of slow action potentials...
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The Cardiotoxic Effect of Roundup® is not Induced by Glyphosate: A Non-specific Blockade of Human CaV1.2 Channels
In Roundup®, the active principle glyphosate is formulated with adjuvants that help it to penetrate the plants’ cell membranes. Several reports and...
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Histamine H3 Receptor Activation Modulates Glutamate Release in the Corticostriatal Synapse by Acting at CaV2.1 (P/Q-Type) Calcium Channels and GIRK (KIR3) Potassium Channels
The striatum is innervated by histaminergic fibers and expresses a high density of histamine H 3 receptors (H 3 Rs), present on medium spiny neurons...
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Trimethyltin Increases Intracellular Ca2+ Via L-Type Voltage-Gated Calcium Channels and Promotes Inflammatory Phenotype in Rat Astrocytes In Vitro
Astrocytes are the first responders to noxious stimuli by undergoing cellular and functional transition referred as reactive gliosis. Every acute or...
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Influence of Hemantane on Changes in Ca2+ and Na+ Caused by Activation of NMDA Channels in Cultured Rat Brain Neurons
Abstract —One of the leading mechanisms of neurodegeneration in Parkinson’s disease is excitotoxicity of glutamate, the main excitatory brain...
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Geniposide Alleviates Neuropathic Pain in CCI Rats by Inhibiting the EGFR/PI3K/AKT Pathway And Ca2+ Channels
Neuropathic pain (NP) is a common disorder among individuals worldwide, but there is still no effective treatment for NP. The EGFR pathway promotes...
