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Ultra-sensitive CTC-based liquid biopsy for pancreatic cancer enabled by large blood volume analysis
The limited sensitivity of circulating tumor cell (CTC) detection in pancreatic adenocarcinoma (PDAC) stems from their extremely low concentration in...
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Circulating Tumor Cells (CTC) and Tumor-Derived Extracellular Vesicles (tdEV)
The observation that increasing circulating tumor cell (CTC) and tumor-derived extracellular vesicle (tdEV) load is directly related to worse...
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FOXD1-dependent RalA-ANXA2-Src complex promotes CTC formation in breast cancer
BackgroundEarly metastasis is a key factor contributing to poor breast cancer (BC) prognosis. Circulating tumor cells (CTCs) are regarded as the...
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CTC-Based Liquid Biopsies and Diagnostic Leukapheresis
Circulating tumor cells (CTCs) appear as ideal tissue surrogate to inform on molecular characteristics of systemic cancer for rational therapeutic...
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Insight into Intratumoral Heterogeneity Through Single CTC Sequencing and CDX Analysis
Tumors contain a high degree of molecular heterogeneity which is the substrate of therapeutic resistance and is rooted both by genomic instability...
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Abnormal expression of long non-coding RNAs RMRP, CTC-487M23.5, and DGCR5 in the peripheral blood of patients with Bipolar disorder
Long non-coding RNAs (lncRNAs) have been recently considered as one of the regulatory mechanisms of the nervous system. Hence, lncRNAs may be...
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Microfluidics, CTC Capture, Analysis and Expansion
Cancer remains among the most common causes of morbidity and mortality worldwide. Although screening methods and better systemic treatment have led...
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Detecting androgen receptor (AR), AR variant 7 (AR-V7), prostate-specific membrane antigen (PSMA), and prostate-specific antigen (PSA) gene expression in CTCs and plasma exosome-derived cfRNA in patients with metastatic castration-resistant prostate cancer (mCRPC) by integrating the VTX-1 CTC isolation system with the QIAGEN AdnaTest
BackgroundTherapies for metastatic castration-resistant prostate cancer (mCRPC) include targeting the androgen receptor (AR) with androgen receptor...
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The prognostic value of circulating tumour cells (CTCs) and CTC white blood cell clusters in patients with renal cell carcinoma
PurposeCirculating tumour cell (CTC) and CTC-white blood cell (CTC-WBC) clusters are related to the prognosis of tumour patients. However, the...
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In Vivo Detection of CTC and CTC Plakoglobin Status Helps Predict Prognosis in Patients with Metastatic Breast Cancer
This study aims to detect the prognostic value of circulating tumour cell (CTC) in patients with metastatic breast cancer. In this study, 38 patients...
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Systematic optimization and evaluation of culture conditions for the construction of circulating tumor cell clusters using breast cancer cell lines
BackgroundCirculating tumor cell (CTC) clusters play a critical role in carcinoma metastasis. However, the rarity of CTC clusters and the limitations...
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Development and Validation of Molecular Assays for Liquid Biopsy Applications
CTC analysis has already been shown to have an important impact on the prognosis, treatment selection, and monitoring of cancer patients. In this...
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State of the Art in the Propagation of Circulating Tumor Cells
Circulating tumor cells (CTCs) are a group of cells that travel through the circulatory system of a cancer patient, sowing distant sites and forming...
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Relevance of CTC Clusters in Breast Cancer Metastasis
Metastasis is the major cause of mortality in patients with breast cancer; however, the mechanisms of tumor cell dissemination and metastasis...
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Circulating Tumor Cells Advances in Liquid Biopsy Technologies
It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis,...
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Circulating tumor cells in early lobular versus ductal breast cancer and their associations with prognosis
This is a secondary data analysis of the TIPPING study, which included 1,121 patients with stage I-III breast cancer who had enumeration of CTCs (by...
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Prognostic value of circulating tumor cells associated with white blood cells in solid cancer: a systematic review and meta-analysis of 1471 patients with solid tumors
BackgroundThe clinical relevance of circulating tumor cell-white blood cell (CTC-WBC) clusters in cancer prognosis is a subject of ongoing debate....
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Diagnostic leukapheresis reveals distinct phenotypes of NSCLC circulating tumor cells
BackgroundCirculating tumor cells (CTCs) hold immense promise for unraveling tumor heterogeneity and understanding treatment resistance. However,...
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Tumor burden score and carcinoembryonic antigen predict outcomes in patients with intrahepatic cholangiocarcinoma following liver resection: a multi‑institutional analysis
BackgroundThe prognostic significance of tumor burden score (TBS) in relation to carcinoembryonic antigen (CEA) has not been investigated among...
