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A Novel Naphthylidene-diimine Chemosensor for Selective Colorimetric and Fluorometric Detection of Al3+ and CN− Ions
A naphthylidene-diimine L 2 was newly designed, and its structure was identified by elemental analysis and spectroscopic methods. The effect of...
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Fluorescent Carbon Dots: Aggregation-Induced Emission Enhancement, Application as Probe for CN− and Cr2O7−2, Sensing Strips and Bio-imaging Agent
Fluorescent carbon dots (Trp-CDs) were prepared using tryptophan as precursor and were characterized on the basis of elemental analysis, powder-XRD,...
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Prophylactic treatment with CN-105 improves functional outcomes in a murine model of closed head injury
The treatment of traumatic brain injury (TBI) in military populations is hindered by underreporting and underdiagnosis. Clinical symptoms and...
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A Reversible Fluorescent Chemosensor for the Selective Detection of Cu2+ and CN- ions by Displacement Approach
A novel fluorescence chemosensor BDP (2-(1-(benzothiazol-2-yl)-5-(4-(diphenylamino)phenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenol) has been synthesized...
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HLX11, a Proposed Pertuzumab Biosimilar: Pharmacokinetics, Immunogenicity, and Safety Profiles Compared to Three Reference Biologic Products (US-, EU-, and CN-Approved Pertuzumab) Administered to Healthy Male Subjects
BackgroundPertuzumab is a humanized monoclonal antibody for the treatment of breast cancer. HLX11 is a biosimilar of pertuzumab developed by Shanghai...
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A Novel Coumarin-based Fluorescent Probe with Aggregation Induced Emission for Detecting CN− and its Applications in Bioimaging
Although cyanogen ion (CN − ) plays important role in industry which also bring acute environmental pollution. More serious, trace CN − enters the human...
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Mechanism of interaction between virus and host is inferred from the changes of gene expression in macrophages infected with African swine fever virus CN/GS/2018 strain
BackgroundAfrican swine fever virus (ASFV) is a highly lethal virus that can infect porcine alveolar macrophages (PAMs). Since ASFV, China has dealt...
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Fluorene Based Ferric Complex as Colorimetric and Fluorometric Probe for Highly Selective Detection of CN− and S2− Anions
A series of new chemosensor molecules bearing benzothiazole-, quinoline- and phthalazine-functionalized fluorene derivatives were synthesized and...
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Enhanced migration of breast and lung cancer cells deficient for cN-II and CD73 via COX-2/PGE2/AKT axis regulation
PurposePurine metabolism involves various intracellular and extracellular enzymes, including cN-II and CD73 that dephosphorylate intracellular and...
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Stereology of the Human Caudate Nucleus
Precise and unbiased quantitative estimations are often necessary in biomedical sciences. Stereological procedures, which were first applied in the...
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Mitochondrial DNA copy number plays opposing roles in T-lymphocyte infiltration of colorectal cancer based on mismatch repair status: new directions for immunotherapy?
BackgroundResearchers have previously reported that mitochondrial DNA copy number (mtDNA-CN) can play different roles in microsatellite...
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Central neurocytoma exhibits radial glial cell signatures with FGFR3 hypomethylation and overexpression
We explored the genomic events underlying central neurocytoma (CN), a rare neoplasm of the central nervous system, via multiomics approaches,...
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Higher peripheral blood mitochondrial DNA copy number and relative telomere length in under 48 years Indonesian breast cancer patients
ObjectiveBreast cancer is the leading cause of cancer incidence and mortality among Indonesian women. A comprehensive investigation is required to...
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Digital PCR quantification of ultrahigh ERBB2 copy number identifies poor breast cancer survival after trastuzumab
HER2/ERBB2 evaluation is necessary for treatment decision-making in breast cancer (BC), however current methods have limitations and considerable...
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Red Fluorescent Molecule with Aggregation-Induced Emission Based on Dehydroabietic Acid Diarylamine for Bioimaging
In this paper, molecules with AIE red light properties were designed by coupling dehydroabietic acid diarylamine and 2,3-diphenylfumaronitrile, which...
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Spectroscopic and Theoretical Studies on the Selective Detection of Cyanide Ions by a Turn-On Fluorescent Chemo-Dosimeter and its Application in Living Cell Imaging
A new chemo-dosimeter AK4 containing quinoline fluorophore has rationally been designed, synthesised and characterized using 1 H and 13 C NMR and mass...
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Cerebellar Nuclei
Understanding the basic physiology of cerebellar nuclei (CN) is essential to the understanding of cerebellar function and disorders as they provide...
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A novel chitosan-based doxepin nano-formulation for chemotherapy-induced oral mucositis: a randomized, double-blinded, placebo-controlled clinical trial
ObjectivesConsidering the prevalence of oral mucositis, we aimed to use the analgesic effects of doxepin with chitosan’s antimicrobial and...
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Multi-Spectroscopic and TD-DFT Studies on Chromogenic and Fluorogenic Detection of Cyanide in an Aqueous Solution
Different spectroscopic techniques and Density Functional Theory (DFT)/Time-Dependent Density Functional Theory (TDDFT) calculations have been...
