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Traumatic brain injury alters the effects of class II invariant peptide (CLIP) antagonism on chronic meningeal CLIP + B cells, neuropathology, and neurobehavioral impairment in 5xFAD mice
BackgroundTraumatic brain injury (TBI) is a significant risk factor for Alzheimer’s disease (AD), and accumulating evidence supports a role for...
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Decoding protein–RNA interactions using CLIP-based methodologies
Protein–RNA interactions are central to all RNA processing events, with pivotal roles in the regulation of gene expression and cellular functions....
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Analysis and comparison of a spinal cord injury model with a single-axle-lever clip or a parallel-moving clip compression in rats
Study designExperimental animal study.
ObjectivesTo assess the feasibility of a custom-designed parallel-moving (PM) clip, compared with a...
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Functional characterization of two clip domain serine proteases in innate immune responses of Aedes aegypti
BackgroundClip domain serine proteases (CLIPs), a very diverse group of proteolytic enzymes, play a crucial role in the innate immunity of insects....
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Iatrogenic dorsal spinal cord herniation and repair with clip-based expansile duraplasty: a case report
IntroductionMyelopathy arising due to dorsal herniation of the spinal cord is a rare phenomenon, particularly so in the thoracic region. Where cases...
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Identification of lncRNA–Protein Interactions by CLIP and RNA Pull-Down Assays
The emerging data indicates that long noncoding RNAs (lncRNAs) are involved in fundamental biological processes, and their deregulation may lead to...
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Stable expression of large transgenes via the knock-in of an integrase-deficient lentivirus
The targeted insertion and stable expression of a large genetic payload in primary human cells demands methods that are robust, efficient and easy to...
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Implementing a novel capture and ligation probe-PCR method in mass screen and treatment to support malaria elimination efforts in the China-Myanmar border region
BackgroundMass screening and treatment (MSAT) for malaria elimination lacks an ideal diagnostic tool to allow sensitive and affordable test of the...
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The Search for and Functional Analysis of Genetic Variants in microRNA-Binding Sites using Massively Parallel Reporter Assay
A large-scale search for the genetic variants with a bias in the representation of alleles in transcriptome data (AE SNPs) and the binding sites in...
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Crosslinking Immunoprecipitation and qPCR (CLIP-qPCR) Analysis to Map Interactions of Long Noncoding RNAs with Canonical and Non-canonical RNA-Binding Proteins
Mammalian cells express a wide range of transcripts, some protein-coding RNAs (mRNA), and many noncoding (nc) RNAs. Long (l)ncRNAs can modulate...
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Dynamic and stationary brain connectivity during movie watching as revealed by functional MRI
Spatially remote brain regions show synchronized activity as typically revealed by correlated functional MRI (fMRI) signals. An emerging line of...
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A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer
AimChemoresistance is a major cause of treatment failure in colorectal cancer (CRC) therapy. In this study, the impact of the IGF2BP family of...
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Advances in post-operative prognostic models for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignancies and a leading cause of cancer-related death worldwide. Surgery remains the...
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Clip Impact-Compression Model
In human spinal cord injury, the most common mechanism is the combination of acute impact and continuing compression. To simulate combined...
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Ultrasound-guided dual-localization for axillary nodes before and after neoadjuvant chemotherapy with clip and activated charcoal in breast cancer patients: a feasibility study
BackgroundWe report on our experience of ultrasound (US)-guided dual-localization for axillary nodes before and after neoadjuvant chemotherapy (NAC)...
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RBM10 regulates alternative splicing of lncRNA Neat1 to inhibit the invasion and metastasis of NSCLC
BackgroundNon-small cell lung cancer (NSCLC) accounts for more than 85% of the total cases with lung cancer. NSCLC is characterized by easy...
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The combination treatment of methylprednisolone and growth factor-rich serum ameliorates the structural and functional changes after spinal cord injury in rat
Study designPreclinical pharmacology.
ObjectivesOur study aims to evaluate the combined effect of Methylprednisolone (MP) and growth factor-rich...
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Quality of life and treatment-related burden during ocular proton therapy: a prospective trial of 131 patients with uveal melanoma
BackgroundProton beam therapy is a well-established treatment option for patients with uveal melanoma (UM). The treatment procedure, in general,...
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Pyridostigmine attenuates hypertension by inhibiting activation of the renin-angiotensin system in the hypothalamic paraventricular nucleus
Activation of the renin-angiotensin system (RAS) triggers oxidative stress and an inflammatory response in the hypothalamic paraventricular nucleus...
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Parathyroid hormone stimulates bone regeneration in an atrophic non-union model in aged mice
BackgroundNon-union formation still represents a major burden in trauma and orthopedic surgery. Moreover, aged patients are at an increased risk for...
