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Computational Modeling of Antibody and T-Cell Receptor (CDR3 Loops)
Antibodies and T-cell receptors have been a subject of much interest due to their central role in the immune system and their potential applications...
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IMGT® Immunoinformatics Tools for Standardized V-DOMAIN Analysis
The variable domains (V-DOMAIN) of the antigen receptors, immunoglobulins (IG) or antibodies and T cell receptors (TR), which specifically recognize...
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The dengue-specific immune response and antibody identification with machine learning
Dengue virus poses a serious threat to global health and there is no specific therapeutic for it. Broadly neutralizing antibodies recognizing all...
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Thermal Stability Estimation of Single Domain Antibodies Using Molecular Dynamics Simulations
In this chapter, we describe a protocol to estimate the thermal stability of single domain antibodies (sdAbs) using molecular dynamics (MD)...
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TCR repertoire landscape reveals macrophage-mediated clone deletion in endotoxin tolerance
BackgroundEndotoxin tolerance (ET) is a protective mechanism in the process of sepsis, septic shock, and their sequelae including uncontrolled...
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A high affinity and specificity anti-HER2 single-domain antibody (VHH) that targets trastuzumab’s epitope with versatile biochemical, biological, and medical applications
In the past decade, various single-domain antibodies from llamas, also known as VHH or nanobody, have been discovered with applications in tumor...
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A new strategy: identification of specific antibodies for neutralizing epitope on SARS-CoV-2 S protein by LC-MS/MS combined with immune repertoire
Although the SARS-CoV-2 vaccine has been widely used worldwide, not all individuals can produce neutralization antibodies, so it is still urgent to...
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The intrarenal landscape of T cell receptor repertoire in clear cell renal cell cancer
BackgroundClear cell renal cell cancer (ccRCC) is accompanied by T-cell infiltration. In this study, we sought to determine the difference in T-cell...
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Camelid Single-Domain Antibodies for the Development of Potent Diagnosis Platforms
The distinct biophysical and pharmaceutical properties of camelid single-domain antibodies, referred to as VHHs or nanobodies, are associated with...
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T Cell Repertoire Abnormality in Immunodeficiency Patients with DNA Repair and Methylation Defects
Both DNA damage response and methylation play a crucial role in antigen receptor recombination by creating a diverse repertoire in develo**...
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Camelid Single-Domain Antibodies for Targeting Cancer Nanotheranostics
Single-domain antibodies (VHHs), in particular those engineered from the variable heavy-chain fragment (VHH gene) found in Camelidae heavy-chain...
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Structure-based design and construction of a synthetic phage display nanobody library
ObjectiveTo design and construct a new synthetic nanobody library using a structure-based approach that seeks to maintain high protein stability and...
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Purpose-Built Immunoinformatics for BcR IG /TR Repertoire Data Analysis
The study of antigen receptor gene repertoires using next-generation sequencing (NGS) technologies has disclosed an unprecedented depth of...
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Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study
BackgroundCommercial anti-CD19 chimeric antigen receptor T-cell therapies (CART19) are efficacious against advanced B-cell non-Hodgkin lymphoma...
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A Novel Heterozygous Variant in AICDA Impairs Ig Class Switching and Somatic Hypermutation in Human B Cells and is Associated with Autosomal Dominant HIGM2 Syndrome
B cells and their secreted antibodies are fundamental for host-defense against pathogens. The generation of high-affinity class switched antibodies...
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Functional and structural characteristics of HLA-B*13:01-mediated specific T cells reaction in dapsone-induced drug hypersensitivity
BackgroundSevere cutaneous adverse drug reactions (SCARs) are a group of serious clinical conditions caused by immune reaction to certain drugs. The...
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Antibody Sequence and Structure Analyses Using IMGT®: 30 Years of Immunoinformatics
IMGT®, the international ImMunoGeneTics information system®, http://www.imgt.org , the global...
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Receptors in Immunodiagnostics: Antibodies, Antibody Fragments, Single Domain Antibodies and Aptamers
Immunodiagnostics that can detect the target analytes such as organic molecules, pathogens, synthetic chemicals, in the sample with high sensitivity...
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A lesion-selective albumin-CTLA4Ig as a safe and effective treatment for collagen-induced arthritis
BackgroundCTLA4Ig is a dimeric fusion protein of the extracellular domain of cytotoxic T-lymphocyte protein 4 (CTLA4) and an Fc (Ig) fragment of...
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Immunoglobulin and T cell receptor repertoire changes induced by a prototype vaccine against Chagas disease in naïve rhesus macaques
BackgroundA vaccine against Trypanosoma cruzi , the agent of Chagas disease, would be an excellent additional tool for disease control. A recombinant...
