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X-linked hyper-immunoglobulin M syndrome harboring a novel CD40-ligand gene mutation: a case report
The X-linked hyper-IgM syndrome (X-HIGM1) is a rare primary immunodeficiency disorder (PID) caused by mutations in the gene encoding the CD154...
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Microcirculatory disturbance in acute liver injury is triggered by IFNγ-CD40 axis
BackgroundAcute liver failure (ALF) is a life-threatening disorder that progresses from self-limiting acute liver injury (ALI). Microcirculatory...
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CD40 ligand stimulation affects the number and memory phenotypes of human peripheral CD8+ T cells
BackgroundCD40L is primarily expressed on activated CD4 + T cells and binds to CD40 which is expressed by various cells including dendritic cells,...
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Clinical and Immunological Features, Genetic Variants, and Outcomes of Patients with CD40 Deficiency
PurposeInherited deficiencies of CD40 and CD40 ligand (CD40L) reflect the crucial immunological functions of CD40–CD40L interaction/signaling....
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CD40 Ligand Deficiency in Latin America: Clinical, Immunological, and Genetic Characteristics
CD40 ligand (CD40L) deficiency is a rare inborn error of immunity presenting with heterogeneous clinical manifestations. While a detailed...
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OX40 and CD40 Agonists for the Treatment of Lung Cancer
Lung cancer is the most common cause of morbidity and mortality in worldwide. Lung cancer is frequently discovered at advanced ages in a high number...
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Mechanisms of CD40-dependent cDC1 licensing beyond costimulation
CD40 signaling in classical type 1 dendritic cells (cDC1s) is required for CD8 T cell-mediated tumor rejection, but the underlying mechanisms are...
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CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions
Exposure of lipopolysaccharide triggers macrophage pro-inflammatory polarization accompanied by metabolic reprogramming, characterized by elevated...
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A bedside to bench study of anti-PD-1, anti-CD40, and anti-CSF1R indicates that more is not necessarily better
BackgroundStimulating inflammatory tumor associated macrophages can overcome resistance to PD-(L)1 blockade. We previously conducted a phase I trial...
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Immunostimulatory gene therapy targeting CD40, 4-1BB and IL-2R activates DCs and stimulates antigen-specific T-cell and NK-cell responses in melanoma models
BackgroundThe activation of dendritic cells (DCs) is pivotal for generating antigen-specific T-cell responses to eradicate tumor cells. Hence,...
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Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy
HighlightsCD40 expression correlates with the type I anti-tumor response and better survival.
Pan-cancer bioinformatics characterization reveals...
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Novel induction of CD40 expression by tumor cells with RAS/RAF/PI3K pathway inhibition augments response to checkpoint blockade
BackgroundWhile immune checkpoint blockade (ICB) is the current first-line treatment for metastatic melanoma, it is effective for ~ 52% of patients...
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Advances in Therapeutic Targeting of the Tumor Necrosis Factor Receptor Superfamily Members for Cancer Immunotherapy
The tumor necrosis factor receptor superfamily (TNFRSF) is a pivotal immunoregulatory group of receptors involved in almost all aspects of immunity....
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Gene-Gut-Brain Axis: Gene-Based Personalized Medicine
The human genome is composed of three billion base pairs that include coding and noncoding sequences. The coding sequences encode for more than...
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Unveiling mitochondrial and ribosomal gene deregulation and tumor microenvironment dynamics in acute myeloid leukemia
Acute myeloid leukemia (AML) is a malignant clonal hematopoietic disease with a poor prognosis. Understanding the interaction between leukemic cells...
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Meta-analysis of the Selected Genetic Variants in Immune-Related Genes and Multiple Sclerosis Risk
Previous studies have suggested that certain variants in immune-related genes may participate in the pathogenesis of multiple sclerosis (MS),...
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Epigenetic targets of Janus kinase inhibitors are linked to genetic risks of rheumatoid arthritis
BackgroundCurrent strategies that target cytokines (e.g., tumor necrosis factor (TNF)-α), or signaling molecules (e.g., Janus kinase (JAK)) have...
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Class-Switch Defects
Immunoglobulin class switching from IgM and IgD to IgG, IgA, or IgE is a mechanism to generate diverse antibody effector functions while retaining...