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CD4+ T cell memory
Specialized subpopulations of CD4 + T cells survey major histocompatibility complex class II–peptide complexes to control phagosomal infections, help...
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Single-cell multiomic analysis of thymocyte development reveals drivers of CD4+ T cell and CD8+ T cell lineage commitment
The development of CD4 + T cells and CD8 + T cells in the thymus is critical to adaptive immunity and is widely studied as a model of lineage...
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CD4+ T cell immunity is dependent on an intrinsic stem-like program
CD4 + T cells are central to various immune responses, but the molecular programs that drive and maintain CD4 + T cell immunity are not entirely clear....
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CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors
CD4 + T cells can "help” or "license” conventional type 1 dendritic cells (cDC1s) to induce CD8 + cytotoxic T lymphocyte (CTL) anticancer responses, as...
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CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity
Antiviral CD8 + T cell immunity depends on the integration of various contextual cues, but how antigen-presenting cells (APCs) consolidate these...
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Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma
Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T cell rich tumors fail to respond to immune checkpoint...
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Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis
BackgroundImmune-mediated arthritis is a group of autoinflammatory diseases, where the patient’s own immune system attacks and destroys synovial...
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Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors
CD4 + T cells play key roles in a range of immune responses, either as direct effectors or through accessory cells, including CD8 + T lymphocytes. In...
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Prmt5 deficiency inhibits CD4+ T-cell Klf2/S1pr1 expression and ameliorates EAE disease
BackgroundProtein arginine methyltransferase 5 (Prmt5) is the main type II methyltransferase, catalyzes protein arginine residue symmetric...
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m6A methyltransferase METTL3 programs CD4+ T-cell activation and effector T-cell differentiation in systemic lupus erythematosus
BackgroundSystemic lupus erythematosus (SLE) is an autoimmune disorder in which excessive CD4 + T-cell activation and imbalanced effector T-cell...
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CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative disorder characterized by the loss of upper and lower motor...
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Modulation of plasmacytoid dendritic cell and CD4+ T cell differentiation accompanied by upregulation of the cholinergic anti-inflammatory pathway induced by enterovirus 71
Enterovirus 71 (EV71) is a neurotropic enterovirus associated with hand, foot, and mouth disease (HFMD) fatalities. In this study, we investigated...
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Astragaloside IV Inhibits Rotenone-Induced α-syn Presentation and the CD4 T-Cell Immune Response
The increased α-synuclein (α-syn)-dependent activation of CD4 T cells leads to the progressive loss of dopaminergic (DA) neurons in the substantia...
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The endogenous repertoire harbors self-reactive CD4+ T cell clones that adopt a follicular helper T cell-like phenotype at steady state
The T cell repertoire of healthy mice and humans harbors self-reactive CD4 + conventional T (T conv ) cells capable of inducing autoimmunity. Using T...
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High-Dimensional Single-Cell Profiling of Tumor-Infiltrating CD4+ Regulatory T Cells
CD4+ T regulatory cells (Tregs) are a specialized subset of T lymphocytes, which promote immune homeostasis and tumor immunosuppression by...
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Correlative CD4 and CD8 T-cell immunodominance in humans and mice: Implications for preclinical testing
Antigen-specific T-cell recognition is restricted by Major Histocompatibility Complex (MHC) molecules, and differences between CD4 and CD8...
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Intestinal endothelial cells increase HIV infection and latency in resting and activated CD4 + T cells, particularly affecting CCR6 + CD4 + T cells
BackgroundWith suppressive antiretroviral therapy, HIV infection is well-managed in most patients. However, eradication and cure are still beyond...
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Mutations in SARS-CoV-2 spike protein impair epitope-specific CD4+ T cell recognition
CD4 + T cells are essential for protection against viruses, including SARS-CoV-2. The sensitivity of CD4 + T cells to mutations in SARS-CoV-2 variants...
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CD4 T cell epitope abundance in ferritin core potentiates responses to hemagglutinin nanoparticle vaccines
Nanoparticle vaccines based on H. pylori ferritin are increasingly used as a vaccine platform for many pathogens, including RSV, influenza, and...
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Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells
Tissue-resident memory T cells (T RM cells) provide rapid and superior control of localized infections. While the transcription factor Runx3 is a...
