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CD34+ synovial fibroblasts exhibit high osteogenic potential in synovial chondromatosis
Synovial chondromatosis (SC) is a disorder of the synovium characterized by the formation of osteochondral nodules within the synovium. This study...
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CD34 Protein: Its expression and function in inflammation
CD34 has spear-headed the field of basic research and clinical transplantation since the first reports of its expression on hematopoietic stem cells...
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Identification and protective role of CD34+ stromal cells/telocytes in experimental autoimmune encephalomyelitis (EAE) mouse spleen
Experimental autoimmune encephalomyelitis (EAE) is a classical animal model of human multiple sclerosis (MS) that is most commonly used to study the...
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Neutrophils cultured ex vivo from CD34+ stem cells are immature and genetically tractable
BackgroundNeutrophils are granulocytes with essential antimicrobial effector functions and short lifespans. During infection or sterile inflammation,...
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Integration of CD34+CD117dim population signature improves the prognosis prediction of acute myeloid leukemia
BackgroundAcute Myeloid Leukemia (AML) is a hematological cancer characterized by heterogeneous hematopoietic cells. Through the use of...
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Effect of expansion of human umbilical cord blood CD34 + cells on neurotrophic and angiogenic factor expression and function
The use of CD34 + cell-based therapies has largely been focused on haematological conditions. However, there is increasing evidence that umbilical...
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Histological study of the role of CD34+ stem cells and mast cells in cyclophosphamide-induced thymic injury in rats and the possible attenuating role of melatonin
Cyclophosphamide (CP) is an anticancer drug that adversely affects immunity and thymus structure. Melatonin is a hormone secreted by the pineal...
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Mild or Moderate COVID-19 during Pregnancy Does Not Affect the Content of CD34+ Hematopoietic Stem Cells in Umbilical Cord Blood of Newborns
The study included umbilical cord blood samples ( n =64) intended for cryogenic storage of hematopoietic stem cells and obtained from patients with a...
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Correlation between peripheral blood neutrophil-lymphocyte ratio and CD34 expression in prostate cancer
BackgroundsThe association of neutrophil-lymphocyte ratio (NLR) and CD34 expression level with PSA level, Gleason score, and clinical stage was...
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Lack of CD34 produces defects in platelets, microparticles, and lung inflammation
Lung innate immune activation results in acute lung inflammation, which is characterized by alveolar barrier disruption and accumulation of cellular...
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Distinct profile of CD34+ cells and plasma-derived extracellular vesicles from triple-negative patients with Myelofibrosis reveals potential markers of aggressive disease
BackgroundMyelofibrosis (MF) is a clonal disorder of hemopoietic stem/progenitor cells (HSPCs) with high prevalence in elderly patients and mutations...
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Mitochondrial augmentation of CD34+ cells from healthy donors and patients with mitochondrial DNA disorders confers functional benefit
Mitochondria are cellular organelles critical for numerous cellular processes and harboring their own circular mitochondrial DNA (mtDNA). Most mtDNA...
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Precise and error-prone CRISPR-directed gene editing activity in human CD34+ cells varies widely among patient samples
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and their associated CRISPR-associated nucleases (Cas) are among the most...
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Aerobically trained older adults show impaired resting, but preserved exercise-induced circulating progenitor cell count, which was not improved by sprint interval training
Older adults exhibit a reduced number and function of CD34 + circulating progenitor cells (CPC), a known risk factor for cardiovascular disease....
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Deconvolution of diffuse gastric cancer and the suppression of CD34 on the BALB/c nude mice model
BackgroundGastric cancer is a considerable burden for worldwide patients. And diffuse gastric cancer is the most insidious subgroup with poor...
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Generation and Culture of Peripheral CD34+ Stem Cell-Derived Mast Cells (PSCMCs)
Mast cells (MCs) are long-living tissue-resident cells that play an important role in inflammatory and allergic reactions. In vitro models of mast...
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Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population
Gangliogliomas are brain tumors composed of neuron-like and macroglia-like components that occur in children and young adults. Gangliogliomas are...
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CD45dimCD34+CD38−CD133+ cells have the potential as leukemic stem cells in acute myeloid leukemia
BackgroundLeukemia stem cells (LSCs) in play an important role in the initiation, relapse, and progression of acute myeloid leukemia (AML), and in...
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Impact of Betamethasone Pretreatment on Engrafment of Cord Blood-Derived Hematopoietic Stem Cells
Hematopoietic stem cell (HSC) transplantation is crucial to cure hematologic malignancies. Umbilical cord blood (UCB) is a source of stem cells, but...
