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Integration of multiomics analyses reveals unique insights into CD24-mediated immunosuppressive tumor microenvironment of breast cancer
BackgroundTumor immunotherapy brings new light and vitality to breast cancer patients, but low response rate and limitations of therapeutic targets...
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Associations of stem cell markers CD44, CD24 and ALDH1A1 with mammographic breast density in women with benign breast biopsies
BackgroundWe examined associations of CD44, CD24 and ALDH1A1 breast stem cell markers with mammographic breast density (MBD), a well-established...
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Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease
Adult kidney organoids have been described as strictly tubular epithelia and termed tubuloids. While the cellular origin of tubuloids has remained...
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Knock-Down of CD24 in Astrocytes Aggravates Oxyhemoglobin-Induced Hippocampal Neuron Impairment
Subarachnoid hemorrhage (SAH), as one of the most severe hemorrhagic strokes, is closely related to neuronal damage. Neurogenesis is a promising...
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Nucleophosmin/B23 promotes endometrial cancer cell escape from macrophage phagocytosis by increasing CD24 expression
AbstractDespite recent therapeutic breakthroughs, advanced and/or recurrent endometrial cancer still poses a significant health burden globally....
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CD19+CD24hiCD38hi regulatory B cells deficiency revealed severity and poor prognosis in patients with sepsis
BackgroundSepsis still remains a major challenge in intensive care medicine with unacceptably high mortality among patients with septic shock. Due to...
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Assessing the causal relationship between 731 immunophenotypes and the risk of lung cancer: a bidirectional mendelian randomization study
BackgroundPrevious studies have observed a link between immunophenotypes and lung cancer, both of which are closely associated with genetic factors....
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Genetic profiling of different phenotypic subsets of breast cancer stem cells (BCSCs) in breast cancer patients
BackgroundBreast cancer stem cells (BCSCs) have a crucial role in breast carcinogenesis, development, and progression. The aim of the current study...
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Impact of media compositions and culture systems on the immunophenotypes of patient-derived breast cancer cells
BackgroundHeterogeneous tumor cells are thought to be a significant factor in the failure of endocrine therapy in estrogen receptor-positive (ER+)...
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Peg-IFNα combined with hepatitis B vaccination contributes to HBsAg seroconversion and improved immune function
PurposeThe purpose of this study was to investigate immunological variations between a group that received the hepatitis B vaccine and a non-vaccine...
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Cancer Stem Cells
Cancer stem cells (CSCs) share traits with healthy stem or precursor cells, which include having the capacity to self-renew and differentiate into...
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Exosomes multiplex profiling, a promising strategy for early diagnosis of laryngeal cancer
BackgroundExosomes are nanosized vesicles released from all cells into surrounding biofluids, including cancer cells, and represent a very promising...
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Direct cell-to-cell transfer in stressed tumor microenvironment aggravates tumorigenic or metastatic potential in pancreatic cancer
Pancreatic cancer exhibits a characteristic tumor microenvironment (TME) due to enhanced fibrosis and hypoxia and is particularly resistant to...
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Cuproptosis engages in c-Myc-mediated breast cancer stemness
BackgroundIntra-tumoral heterogeneity (ITH) is a distinguished hallmark of cancer, and cancer stem cells (CSCs) contribute to this malignant...
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TRIM58 downregulation maintains stemness via MYH9-GRK3-YAP axis activation in triple-negative breast cancer stem cells
TRIM58 is a member of the TRIM protein family, which possess with E3 ubiquitin ligase activities. Studies have revealed that low expression of TRIM58...
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Estrogen-related genes for thyroid cancer prognosis, immune infiltration, staging, and drug sensitivity
BackgroundThyroid cancer (THCA) has become increasingly common in recent decades, and women are three to four times more likely to develop it than...
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High CD133 expression in proximal tubular cells in diabetic kidney disease: good or bad?
BackgroundProximal tubular cells (PTCs) play a critical role in the progression of diabetic kidney disease (DKD). As one of important progenitor...
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Causal relationship between immune cells and telomere length: mendelian randomization analysis
BackgroundThe causal relationship between immune cells and telomere length remains controversial.
MethodsData on the immune cells were obtained from...
