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Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice
BackgroundPostoperative cognitive dysfunction (POCD) is a neurological complication occurring after anesthesia and surgery. Neuroinflammation plays a...
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Altered expression of the immunoregulatory ligand-receptor pair CD200-CD200R1 in the brain of Parkinson’s disease patients
Neuroinflammation, in which activated microglia are involved, appears to contribute to the development of Parkinson’s disease (PD). However, the role...
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Activation of CD200-CD200R1 Axis Attenuates Perioperative Neurocognitive Disorder Through Inhibition of Neuroinflammation in Mice
Perioperative neurocognitive disorder (PND) is the mild cognitive impairment associated with surgery and anesthesia. It is a common surgical...
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The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson’s disease
BackgroundIt is suggested that neuroinflammation, in which activated microglial cells play a relevant role, contributes to the development of...
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CD200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation
BackgroundNeuroinflammation and microglia play critical roles in the development of depression. Cluster of differentiation 200 (CD200) is an...
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CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis
Fibroblasts are important regulators of inflammation, but whether fibroblasts change phenotype during resolution of inflammation is not clear. Here...
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Anti-angiogenic and anti-inflammatory effects of CD200–CD200R1 axis in oxygen-induced retinopathy mice model
ObjectiveIn this study, the expression changes and the potential effects of CD200 and its receptors during the process of retinal neovascularization...
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The role of N-glycosylation of CD200-CD200R1 interaction in classical microglial activation
BackgroundMicroglial inflammatory activation is the common feature of the central nervous system (CNS) diseases. Microglia can be activated and...
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CD200-CD200R1 inhibitory signaling prevents spontaneous bacterial infection and promotes resolution of neuroinflammation and recovery after stroke
BackgroundIschemic stroke results in a robust inflammatory response within the central nervous system. As the immune-inhibitory CD200-CD200 receptor...
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Microglia in retinal angiogenesis and diabetic retinopathy
Diabetic retinopathy has a high probability of causing visual impairment or blindness throughout the disease progression and is characterized by the...
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Blockade of novel immune checkpoints and new therapeutic combinations to boost antitumor immunity
Immunotherapy has emerged as a promising strategy for boosting antitumoral immunity. Blockade of immune checkpoints (ICs), which regulate the...
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Strategies for improving the performance of prediction models for response to immune checkpoint blockade therapy in cancer
Immune checkpoint blockade (ICB) therapy holds promise for bringing long-lasting clinical gains for the treatment of cancer. However, studies show...
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CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway
Numerous therapies aimed at driving an effective anti-glioma response have been employed over the last decade; nevertheless, survival outcomes for...
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Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity
White adipose tissue (WAT) is an essential regulator of energy storage and systemic metabolic homeostasis. Regulatory networks consisting of immune...
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CD200Fc Attenuates Retinal Glial Responses and RGCs Apoptosis After Optic Nerve Crush by Modulating CD200/CD200R1 Interaction
To explore the hypothesis that CD200Fc, a CD200R1 agonist with anti-inflammatory properties, will inhibit retinal glial cells hyperactivation and...
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What role does GPR65 play in the progression of osteosarcoma? Its mechanism and clinical significance
BackgroundGPR65 is a pH-sensing G-protein-coupled receptor that acts as a key innate immune checkpoint in the human tumor microenvironment,...
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Taming microglia: the promise of engineered microglia in treating neurological diseases
Microglia, the CNS-resident immune cells, are implicated in many neurological diseases. Nearly one in six of the world’s population suffers from...
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Pharmacological and Nutritional Approaches to Modulate Microglial Polarization in Cognitive Senescence
Brain aging, characterized by age-related changes, significantly impacts cognitive function. Microglia cells are resident macrophages in the CNS that...
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Targeting neuroinflammation as a preventive and therapeutic approach for perioperative neurocognitive disorders
Perioperative neurocognitive disorders (PND) is a common postoperative complication associated with regional or general anesthesia and surgery....
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Microglia Aging
“Microglia aging” is about the aging of microglia and its role in the aging brain. With age, microglia get converted to divergent phenotypes with...