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CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis
Fibroblasts are important regulators of inflammation, but whether fibroblasts change phenotype during resolution of inflammation is not clear. Here...
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CD200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation
BackgroundNeuroinflammation and microglia play critical roles in the development of depression. Cluster of differentiation 200 (CD200) is an...
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Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice
BackgroundPostoperative cognitive dysfunction (POCD) is a neurological complication occurring after anesthesia and surgery. Neuroinflammation plays a...
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Altered expression of the immunoregulatory ligand-receptor pair CD200-CD200R1 in the brain of Parkinson’s disease patients
Neuroinflammation, in which activated microglia are involved, appears to contribute to the development of Parkinson’s disease (PD). However, the role...
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Activation of CD200-CD200R1 Axis Attenuates Perioperative Neurocognitive Disorder Through Inhibition of Neuroinflammation in Mice
Perioperative neurocognitive disorder (PND) is the mild cognitive impairment associated with surgery and anesthesia. It is a common surgical...
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CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway
Numerous therapies aimed at driving an effective anti-glioma response have been employed over the last decade; nevertheless, survival outcomes for...
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The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke
BackgroundSpontaneous functional recovery occurs during the acute phase after stroke onset, but this intrinsic recovery remains limited. Therefore,...
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The prenatal challenge with lipopolysaccharide and polyinosinic:polycytidylic acid disrupts CX3CL1-CX3CR1 and CD200-CD200R signalling in the brains of male rat offspring: a link to schizophrenia-like behaviours
BackgroundThe bidirectional communication between neurons and microglia is fundamental for the homeostasis and biological function of the central...
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CD200Rhigh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory T cells
Distinct neutrophil populations arise during certain pathological conditions. The generation of dysfunctional neutrophils during sepsis and their...
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Exploration of Key Immune-Related Transcriptomes Associated with Doxorubicin-Induced Cardiotoxicity in Patients with Breast Cancer
Based on a few studies, heart failure patients with breast cancer were assessed to find potential biomarkers for doxorubicin-induced cardiotoxicity....
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Upregulated CD200 in pre-retinal proliferative fibrovascular membranes of proliferative diabetic retinopathy patients and its correlation with vascular endothelial growth factor
Objective and designThe objective was to determine the expression of CD200 in the pre-retinal proliferative fibrovascular membranes (PFVM) of...
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Anti-angiogenic and anti-inflammatory effects of CD200–CD200R1 axis in oxygen-induced retinopathy mice model
ObjectiveIn this study, the expression changes and the potential effects of CD200 and its receptors during the process of retinal neovascularization...
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Genome-Wide Selection Signal Analysis of Australian Boer Goat by Insertion/Deletion Variants
AbstractSelection in breeds for commercial goat is needed for production efficiency, growth trait alteration, and improved livestock quality. Boer...
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Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts
The immunogenicity of transplanted allogeneic cells and tissues is a major hurdle to the advancement of cell therapies. Here we show that the...
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The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson’s disease
BackgroundIt is suggested that neuroinflammation, in which activated microglial cells play a relevant role, contributes to the development of...
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Long intergenic non-coding RNA DIO3OS promotes osteosarcoma metastasis via activation of the TGF-β signaling pathway: a potential diagnostic and immunotherapeutic target for osteosarcoma
BackgroundThe aim of this study was to determine the underlying potential mechanisms and function of DIO3OS, a lincRNA in osteosarcoma and clarify...
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Correction to: CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway
A correction to this paper has been published: https://doi.org/10.1007/s13311-021-01062-1
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The role of N-glycosylation of CD200-CD200R1 interaction in classical microglial activation
BackgroundMicroglial inflammatory activation is the common feature of the central nervous system (CNS) diseases. Microglia can be activated and...
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CD200-CD200R1 inhibitory signaling prevents spontaneous bacterial infection and promotes resolution of neuroinflammation and recovery after stroke
BackgroundIschemic stroke results in a robust inflammatory response within the central nervous system. As the immune-inhibitory CD200-CD200 receptor...
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Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-γ pathway
BackgroundThe natural compound asperosaponin VI has shown potential as an antidepressant, but how it works is unclear. Here, we explored its effects...
