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Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease
The neuroinflammatory process in synucleinopathies of the aging population such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB)...
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Redirecting iNKT Cell Antitumor Immunity with α-GalCer/CD1d-scFv Fusion Proteins
Invariant natural killer T (iNKT) cells display important properties that could bridge the innate and adaptive immunity, and they have been shown to...
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Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice
BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent in Western countries, evolving into metabolic...
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Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin
Invariant natural killer T (iNKT) cells recognize activating self and microbial lipids presented by CD1d. CD1d can also bind non-activating lipids,...
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Invariant NKT cells facilitate cytotoxic T-cell activation via direct recognition of CD1d on T cells
Invariant natural killer T (iNKT) cells are a major subset of NKT cells that recognize foreign and endogenous lipid antigens presented by CD1d....
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Regeneration of invariant natural killer T (iNKT) cells: application of iPSC technology for iNKT cell-targeted tumor immunotherapy
Invariant natural killer T (iNKT) cells are a subset of innate-like T cells restricted by a major histocompatibility complex (MHC) class I-like...
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Identification of Non-classical Follicular T Cells
Nonclassical T cells are a heterogeneous group of T lymphocytes that are activated during the early stages of infection and act as a bridge between...
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Nature Killer T (NKT) Cells in Cancer
By identifying foreign antigens expressed on the surface of tumor cells, the immunological system contributes significantly to limiting the...
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Markers and makers of NKT17 cells
Invariant natural killer T ( i NKT) cells are thymus-generated innate-like αβ T cells that undergo terminal differentiation in the thymus. Such a...
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Immunomodulatory properties of characellide A on human peripheral blood mononuclear cells
Marine sponges and their associated microbiota are multicellular animals known to produce metabolites with interesting pharmacological properties...
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Extended interval dosing of ocrelizumab modifies the repopulation of B cells without altering the clinical efficacy in multiple sclerosis
BackgroundRecent studies suggest that extended interval dosing of ocrelizumab, an anti-B cell therapy, does not affect its clinical effectiveness in...
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Impact of molecular surgical margin analysis on the prediction of pancreatic cancer recurrences after pancreaticoduodenectomy
BackgroundPancreatic cancer is one of the lethal cancers among solid malignancies. Pathological diagnosis of surgical margins is sometimes unreliable...
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Isolation and Detection of Murine iNKT Cells in Different Organs
The invariant NKT (iNKT) cells are innate-like lymphocytes that share phenotypic and functional characteristics with NK cells and T cells, playing an...
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The Expansion and Cytotoxicity Detection of Human iNKT Cells
Invariant natural killer T (iNKT) cell is a type of innate-like T cell subsets with both T and NK cell phenotype and functions. They recognize lipid...
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CD1d- and PJA2-related immune microenvironment differs between invasive breast carcinomas with and without a micropapillary feature
BackgroundInvasive micropapillary carcinoma (IMPC) of the breast is characterized by its unique morphology and frequent nodal metastasis. However,...
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The role of regulatory B cells in Echinococcus granulosus-infected mice
To investigate the phenotypic changes of the expression level of regulatory B cells and related molecules during the continuous infection of Echinococc...
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Detection of Mouse Type I NKT (iNKT) Cells by Flow Cytometry
Flow cytometry is an effective tool in immunology that uses laser as a light source to yield scattered and fluorescent light signals read by...
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The Role of Innate T Cells in Cancer
Innate T cells, comprising invariant natural killer T (iNKT) cells, gamma delta T (γδ T) cells, and mucosal-associated invariant T (MAIT) cells,...
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iNKT Cel Transfer: The Use of Cell Sorting Combined with Flow Cytometry Validation Approach
Natural killer T (NKT) cells are an innate-like T cell subset that recognize lipid antigens presented by CD1d-expressing antigen presenting cells...