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Morphological alterations in C57BL/6 mouse intestinal organoids as a tool for predicting chemical-induced toxicity
Intestinal organoid may serve as an alternative model for toxicity testing. However, the linkage between specific morphological alterations in...
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Immunological characteristics of CD103+CD8+ Tc cells in the liver of C57BL/6 mouse infected with plasmodium NSM
CD103 is an important marker of tissue-resident memory T cells (TRM) which play important roles in fighting against infection. However, the...
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Cu,Zn-Superoxide Dismutase has Minimal Effects Against Cuprizone-Induced Demyelination, Microglial Activation, and Neurogenesis Defects in the C57BL/6 Mouse Hippocampus
Cuprizone causes consistent demyelination and oligodendrocyte damage in the mouse brain. Cu,Zn-superoxide dismutase 1 (SOD1) has neuroprotective...
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IFNAR signaling of neuroectodermal cells is essential for the survival of C57BL/6 mice infected with Theiler’s murine encephalomyelitis virus
BackgroundTheiler’s murine encephalomyelitis virus (TMEV) is a single-stranded RNA virus that causes encephalitis followed by chronic demyelination...
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A comparative study of IL-33 and its receptor ST2 in a C57BL/6 J mouse model of pulmonary Cryptococcus neoformans infection
It has been reported that IL-33 receptor ST2 deficiency mitigates Cryptococcus neoformans ( C. neoformans ) pulmonary infection in BALB/c mice. IL-33...
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Spontaneous p53 activation in middle-aged C57BL/6 mice mitigates the lifespan-extending adaptive response induced by low-dose ionizing radiation
Understanding the biological effects of low-dose (<100 mGy) ionizing radiation (LDR) is technically challenging. We investigated age-dependent LDR...
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Sex- and Strain-Related Differences in the Extinction of a Conditioned Passive Avoidance Reaction in DISC-L100P and C57BL/6 Mice
We report here studies of sex-related and interstrain differences in the processes of learning and extinction of a conditioned passive avoidance...
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Common and Specific Effects of Selank, Noopept, and Semax on the Glycine Site of the NMDA Receptor in BALB/c and C57Bl/6 Mice Brains
Abstract —We have examined the effects of the nootropic peptides Selank (300 mg/kg), Noopept (1 mg/kg), and Semax (0.6 mg/kg) after subchronic...
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Bifenthrin Caused Parkinson’s-Like Symptoms Via Mitochondrial Autophagy and Ferroptosis Pathway Stereoselectively in Parkin−/− Mice and C57BL/6 Mice
It has been proposed that pyrethroid exposure contributes to the increasing prevalence of neurodegenerative diseases. However, the potential...
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Characterization of Risk Factors for Modeling of Type 2 Diabetes Mellitus Induced by a High-Fat Diet in C57BL/6 Mice
Type 2 diabetes mellitus develops due to a combination of genetic and environmental factors. C57BL/6 mice prone to obesity and leptin resistance were...
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Light-Induced Functional Pinealectomy. Effect on the Thymus of C57BL/6 Mice
Light-induced functional pinealectomy was simulated in C57BL/6 mice by 14-day exposure to constant lighting. Immunophenoty** of CD3 hi and CD3 low ...
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Effect of Intracerebroventricular Administration of Galanin-Like Peptide on Hepatokines in C57BL/6 J Mice
Galanin-like peptide (GALP) is a neuropeptide that was first isolated and identified from the porcine hypothalamus. Studies have described an...
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Sustain-release lipid-liquid crystal formulations of pexiganan against Helicobacter pylori infection: in vitro evaluation in C57BL/6 mice
IntroductionThe Gram-negative bacterium Helicobacter pylori , H. pylori , is associated with significant digestive disorders. However, the...
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Mouse Melanoma Model in Tumor Vaccines and Immunotherapy Research
Efficacy of novel cancer immunization protocols could be tested in cell line-derived xenograft tumor models (CDX), which are based on the...
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Sex-related differences in delayed doxorubicin-induced cardiac dysfunction in C57BL/6 mice
Cancer survivors may experience long-term cardiovascular complications due to chemotherapeutic drugs such as doxorubicin (DOX). The exact mechanism...
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Motor and Cognitive Functions in Aging C57BL/6 Mice: Association with Activity of the Monoaminergic Systems in the Cerebellum and Frontal Cortex
The activity in the open field, short- and long-term memory in the novel object recognition test, and gait features were evaluated in 6- and...
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NSP4 as adjuvant for immunogenicity and design of effective therapeutic HPV16 E6/E7/L1 DNA vaccine in tumor-bearing and healthy C57BL/6 mice
IntroductionIn humans, approximately 5% of all cancers are attributable to HPV infection. Prophylactic vaccines can inhibit viral migration and...
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Chronic restraint stress–induced depression-like behavior is mediated by upregulation of melanopsin expression in C57BL/6 mice retina
BackgroundDepression is associated with circadian disturbances in which melanopsin was a key mechanism. Further studies have demonstrated that...
