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Clinical outcomes of bulky parotid gland cancers: need for self-examination and screening program for early diagnosis of parotid tumors
BackgroundEarly detection and diagnosis of parotid gland cancer (PGC) are essential to improve clinical outcomes, because Tumor-Node-Metastasis stage...
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Comparison of therapeutic effects of chemo-radiotherapy with neoadjuvant chemotherapy before radical surgery in patients with bulky cervical carcinoma (stage IB3 & IIA2)
BackgroundCervical cancer is one of the most common malignancies among women. Appropriate and timely treatment of these patients can reduce the...
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Body mass index is not associated with survival outcomes and immune-related adverse events in patients with Hodgkin lymphoma treated with the immune checkpoint inhibitor nivolumab
BackgroundOverweight and obese patients with solid tumors receiving anti-programmed cell death-1 (PD-1)/PD-ligand-1 ( PD-L1) immune checkpoint...
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Mass Spectrometry-Based Quantification of β-d-Glucosyl-5-Hydroxymethyluracil in Genomic DNA
Base J, or β-d-glucosyl-5-hydroxymethyluracil, is the first hypermodified nucleobase that has been discovered in eukaryotes. It has been found in the...
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Mass Spectrometry-Based Methods for Immunoglobulin G N-Glycosylation Analysis
Mass spectrometry and its hyphenated techniques enabled by the improvements in liquid chromatography, capillary electrophoresis, novel ionization,...
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Rapid, Sensitive, and Selective "ON–OFF" Detection of Fe3+ Ions Using Novel Acetalophanes and Their Applications in Real Samples
Three novel acetalophanes 1a-c have been designed, synthesized and characterized. The receptors 1b-c , featuring bulky anthracene groups, displayed...
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Producing High-Dose Liqui-Tablet (Ketoprofen 100 mg) for Enhanced Drug Release Using Novel Liqui-Mass Technology
PurposeLiqui-Tablet is a dosage form derived from Liqui-Mass technology. It has proven to be a promising approach to improve drug dissolution rate of...
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Synthesis and cytotoxic/antimicrobial screening of 2-alkenylimidazo[1,2-a]pyrimidines
Polyaza-heterocycles show a plethora of biological properties and represent a significant percentage of clinically used drugs. However, the...
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Evolution of therapy for limited stage diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL), with limited-stage DLBCL defined as stage I or II disease. Risk...
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Analysis of Melanoma Cell Glutamine Metabolism by Stable Isotope Tracing and Gas Chromatography-Mass Spectrometry
Glutamine is a major substrate for biosynthesis. It contributes to multiple pathways required for cell proliferation, supports antioxidant defense...
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Liquisolid System and Liqui-Mass System Are Not the Same
This commentary is written in response to Pezzini’s research group commentary, which claimed Liqui-Pellet and liquisolid pellet are not different....
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Mass spectrometry-based protein-protein interaction techniques and their applications in studies of DNA damage repair
Proteins are major functional units that are tightly connected to form complex and dynamic networks. These networks enable cells and organisms to...
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Novel stereotactic body radiation therapy (SBRT)-based partial tumor irradiation targeting hypoxic segment of bulky tumors (SBRT-PATHY): improvement of the radiotherapy outcome by exploiting the bystander and abscopal effects
BackgroundDespite the advances in oncology, patients with bulky tumors have worse prognosis and often receive only palliative treatments. Bulky...
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Wireless agents for brain recording and stimulation modalities
New sensors and modulators that interact wirelessly with medical modalities unlock uncharted avenues for in situ brain recording and stimulation....
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Adjuvant hysterectomy following primary chemoradiation for stage IB2 and IIA2 cervical cancer: a retrospective comparison of complications for open versus minimally invasive surgery
BackgroundAdjuvant hysterectomy following chemoradiation for bulky, early stage cervical cancer has been shown to decrease local relapse rate. The...
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Proof-of-concept and concurrent validity of a prototype headset to assess peak oxygen uptake without a face mask
ObjectivePortable gas exchange instruments allow the assessment of peak oxygen uptake (V̇O 2peak ) but are often bulky, expensive and require wearing...
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Aortic disease and cardiomyopathy in patients with a novel DNMT3A gene variant causing Tatton-Brown–Rahman syndrome
Tatton-Brown–Rahman syndrome (TBRS) is a rare congenital genetic disorder caused by autosomal dominant pathogenic variants in the DNA...
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Metabolomics of Gastrointestinal Cancers
Cancer is one of the leading causes of death worldwide and a serious health concern for different countries, particularly the most industrialized...
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Parallel Functionalization of DNA Origami
DNA origami enables the creation of large supramolecular structures, with precisely defined features at the nanoscale. The concept thus naturally...
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Optimization of the IntraVascular Oxygenator Catheter Using Angular Oscillation
We demonstrate a methodology which both improves oxygen transport and reduces or eliminates bubble formation in a novel hyperbaric membrane...
