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Energy optimisation predicts the capacity of ion buffering in the brain
Neurons store energy in the ionic concentration gradients they build across their cell membrane. The amount of energy stored, and hence the work the...
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Dual-axes of functional organisation across lateral parietal cortex: the angular gyrus forms part of a multi-modal buffering system
Decades of neuropsychological and neuroimaging evidence have implicated the lateral parietal cortex (LPC) in a myriad of cognitive domains,...
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Beyond Mendelian Inheritance: Genetic Buffering and Phenotype Variability
Understanding the way genes work amongst individuals and across generations to shape form and function is a common theme for many genetic studies....
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Systematic Input–Output Map** Reveals Structural Plasticity of VTA Dopamine Neurons-Zona Incerta Loop Underlying the Social Buffering Effects in Learned Helplessness
A common phenomenon called social buffering (SB), communication within conspecific animals is a benefit for a stressed individual to better recover...
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Dissolution of a Biopharmaceutics Classification System Class II Free Acid from Immediate Release Tablets Containing a Microenvironmental pH Modulator: Comparison of a Biorelevant Bicarbonate Buffering System with Phosphate Buffers
Poor water dissolution of active pharmaceutical ingredients (API) limits the rate of absorption from the gastrointestinal tract. Increasing the pH of...
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Cytoplasmic Calcium Buffering: An Integrative Crosstalk
Calcium (Ca2+) buffering is part of an integrative crosstalk between different mechanisms and elements involved in the control of free Ca2+ ions...
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Membrane tension buffering by caveolae: a role in cancer?
Caveolae are bulb-like invaginations made up of two essential structural proteins, caveolin-1 and cavins, which are abundantly present at the plasma...
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Mitochondrial Calcium Waves by Electrical Stimulation in Cultured Hippocampal Neurons
Mitochondria are critical to cellular Ca 2+ homeostasis via the sequestering of cytosolic Ca 2+ in the mitochondrial matrix. Mitochondrial Ca 2+ ...
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Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury
BackgroundTraumatic brain injury (TBI) is characterized by massive changes in neuronal excitation, from acute excitotoxicity to chronic hyper- or...
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Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion
Tumor cells and surrounding immune cells undergo metabolic reprogramming, leading to an acidic tumor microenvironment. However, it is unclear how...
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Precise modulation of transcription factor levels identifies features underlying dosage sensitivity
Transcriptional regulation exhibits extensive robustness, but human genetics indicates sensitivity to transcription factor (TF) dosage. Reconciling...
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Protein vicinal thiols as intrinsic probes of brain redox states in health, aging, and ischemia
The nature of brain redox metabolism in health, aging, and disease remains to be fully established. Reversible oxidations, to disulfide bonds, of...
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Aging reduces calreticulin expression and alters spontaneous calcium signals in astrocytic endfeet of the mouse dorsolateral striatum
Aging-related impairment of the blood brain barrier (BBB) and neurovascular unit (NVU) increases the risk for neurodegeneration. Among various cells...
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The effects of sodium hydrogen carbonate ingestion during the recovery period between two 200-m front-crawl time trials
PurposeThe aim of this study was to determine how sodium hydrogen carbonate (NaHCO 3 ) ingestion during a 1-h recovery period after a 200-m...
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A yeast phenomic model for the influence of Warburg metabolism on genetic buffering of doxorubicin
BackgroundThe influence of the Warburg phenomenon on chemotherapy response is unknown. Saccharomyces cerevisiae mimics the Warburg effect,...
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The Acute Effect of Citrulline Malate Loading in Resistance Trained Males on: Anaerobic Muscular Endurance, Force Recovery and Muscle Soreness
The use of supplements to enhance performance is popular amongst gym enthusiasts. Citrulline-malate (CM) has been suggested as an effective ergogenic...
