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MiR-19b-3p Inhibits Hypoxia-Ischemia Encephalopathy by Inhibiting SOX6 Expression via Activating Wnt/β-catenin Pathway
Hypoxic-ischemic encephalopathy (HIE) is a detrimental factor in infant death and chronic disease. The specific pathogenesis is not entirely clear....
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Integrating eQTL and GWAS data characterises established and identifies novel migraine risk loci
Migraine—a painful, throbbing headache disorder—is the most common complex brain disorder, yet its molecular mechanisms remain unclear. Genome-wide...
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Mismatch Repair Status Characterization as an Immune-Related Biomarker in Oncology
The mismatch repair (MMR) system recognizes and corrects DNA bases misincorporation formed during replication and recombination, thus maintaining...
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High-throughput circular RNA sequencing reveals the profiles of circular RNA in non-cirrhotic hepatocellular carcinoma
BackgroundLiver cirrhosis is a well-known risk factor for hepatocellular carcinoma (HCC). However, some HCC cases can also originate from...
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Distinct genome-wide DNA methylation and gene expression signatures in classical monocytes from African American patients with systemic sclerosis
BackgroundSystemic sclerosis (SSc) is a multisystem autoimmune disorder that has an unclear etiology and disproportionately affects women and African...
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Genetic Instability Markers in Cancer
High frequency of mutations seems to determine a higher occurrence of neoepitope formation and, thus, tumor immunogenicity. A somatic hypermutated...
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Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression
ObjectivesKelch repeat and BTB domain-containing protein 8, KBTBD8, has been identified as a female fertility factor. However, there have been no...
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Microsatellite instability assessment is instrumental for Predictive, Preventive and Personalised Medicine: status quo and outlook
A form of genomic alteration called microsatellite instability (MSI) occurs in a class of tandem repeats (TRs) called microsatellites (MSs) or short...
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Considerations for feature selection using gene pairs and applications in large-scale dataset integration, novel oncogene discovery, and interpretable cancer screening
BackgroundAdvancements in transcriptomic profiling have led to the emergence of new challenges regarding data integration and interpretability....
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Epigenome-wide association study of bronchopulmonary dysplasia in preterm infants: results from the discovery-BPD program
BackgroundBronchopulmonary dysplasia (BPD) is a lung disease in premature infants caused by therapeutic oxygen supplemental and characterized by...
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A combined epigenome- and transcriptome-wide association study of the oral masticatory mucosa assigns CYP1B1 a central role for epithelial health in smokers
BackgroundThe oral mucosa has an important role in maintaining barrier integrity at the gateway to the gastrointestinal and respiratory tracts....
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Uveitis and Multiple Sclerosis: Potential Common Causal Mutations
Uveitis, defined as inflammation of the uveal tract of the eye, is a leading cause of blindness and visual impairment throughout the world. The...
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A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis
BackgroundHepatocellular carcinoma (HCC) is the most common malignant liver tumor with poor clinical outcomes. Increasing amount of long non-coding...
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Interactions Among Regulatory Non-coding RNAs Involved in Cardiovascular Diseases
Non-coding RNAs (ncRNAs) are important regulatory players in human cells that have been shown to modulate different cellular processes and biological...
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Molecular network-based identification of competing endogenous RNAs and mRNA signatures that predict survival in prostate cancer
BackgroundThe aim of the study is described the regulatory mechanisms and prognostic values of differentially expressed RNAs in prostate cancer and...
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Comprehensive off-target analysis of dCas9-SAM-mediated HIV reactivation via long noncoding RNA and mRNA profiling
BackgroundCRISPR/CAS9 (epi)genome editing revolutionized the field of gene and cell therapy. Our previous study demonstrated that a rapid and robust...
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Btbd7 contributes to reduced E-cadherin expression and predicts poor prognosis in non-small cell lung cancer
BackgroundDisorders of cell adhesion are critical steps in cancer progression in which varieties of markers including cadherins are involved in.Btbd7...
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Δ9-Tetrahydrocannabinol (Δ9-THC) Promotes Neuroimmune-Modulatory MicroRNA Profile in Striatum of Simian Immunodeficiency Virus (SIV)-Infected Macaques
Cannabinoid administration before and after simian immunodeficiency virus (SIV)-inoculation ameliorated disease progression and decreased...
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Gene set enrichment analysis of the NF-κB/Snail/YY1/RKIP circuitry in multiple myeloma
The presence of a dysregulated NF-κB/Snail/YY1/RKIP loop was recently established in metastatic prostate cancer cells and non-Hodgkin’s lymphoma;...
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Understanding mechanisms of vitiligo development in Smyth line of chickens by transcriptomic microarray analysis of evolving autoimmune lesions
BackgroundThe Smyth line (SL) of chicken is an excellent avian model for human autoimmune vitiligo. The etiology of vitiligo is complicated and far...
