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Repetitive diacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans pathology
Bronchiolitis obliterans (BO) is a devastating lung disease seen commonly after lung transplant, following severe respiratory tract infection or...
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Azithromycin for Other Lung Diseases: Lung Transplantation and Sarcoidosis
Azithromycin was introduced in lung transplantation in an attempt to improve the pulmonary function in patients with chronic allograft dysfunction...
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Mesenchymal stem cells reversibly de-differentiate myofibroblasts to fibroblast-like cells by inhibiting the TGF-β-SMAD2/3 pathway
BackgroundMyofibroblasts (MFB), one of the major effectors of pathologic fibrosis, mainly derived from the activation of fibroblast to myofibroblast...
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MiR-27a-3p downregulation contributes to the development of occlusive bronchiolitis
The only effective clinical treatment for many end-stage lung diseases is lung transplantation. However, chronic rejection of transplanted lung...
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Obstructive Airway Diseases
Asthma, COPD (including chronic bronchitis and emphysema), and bronchiectasis are the commonly encountered obstructive airway diseases. Symptomatic...
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Delivery of Therapeutics to Solid Organs Using Ex Vivo Machine Perfusion
The use of ex vivo machine perfusion for organ preservation has significantly improved solid organ transplantation outcomes. This modality of organ...
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Histopathology of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities in a murine model
BackgroundMulti-walled carbon nanotubes and nanofibers (CNT/F) have been previously investigated for their potential toxicities; however, comparative...
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Respiratory Comorbidities Associated with Bronchiectasis in Patients with Common Variable Immunodeficiency in the USIDNET Registry
BackgroundBronchiectasis is a major respiratory complication in patients with common variable immunodeficiency (CVID) and is associated with...
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Lymphocyte-Directed Immunomodulation Remits Thymoma-Associated Autoimmune Pneumonitis
BackgroundThymoma presents with several autoimmune manifestations and is associated with secondary autoimmune regulator (AIRE) deficiency....
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Respiratory Diseases Amongst HIV Infected Children
Respiratory diseases are the commonest opportunistic illnesses seen amongst HIV infected and HIV exposed uninfected children. In infancy, these...
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Stage IV renal cell carcinoma achieves pathologic complete response after two ipilimumab plus nivolumab courses despite severe immune-related adverse events: a case report
BackgroundIpilimumab (Ipi) plus nivolumab (Nivo) is the recommended first-line treatment for renal cell carcinoma (RCC). This report describes a case...
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Perioperative tislelizumab plus chemotherapy for locally advanced resectable thoracic esophageal squamous cell carcinoma trial: a prospective single-arm, phase II study (PILOT trial)
BackgroundThe promising therapeutic outcomes of neoadjuvant immunotherapy combined with chemotherapy in the treatment of locally advanced esophageal...
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Induction Therapy and Therapeutic Antibodies
Prevention of allograft rejection is one of the crucial goals in solid organ transplantation to ensure durability of the graft and is chiefly...
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Recent Advances in Inhaled Nanoformulations of Vaccines and Therapeutics Targeting Respiratory Viral Infections
With the rapid outbreak of respiratory viral infections, various biological (e.g. vaccines, peptides, recombinant proteins, antibodies and genes) and...
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Exosomal-miRNas expression and growth factors released by mononuclear cells of CLAD patients in response to extracorporeal photopheresis
BackgroundCLAD (Chronic Lung Allograft Dysfunction) remains a serious complication following lung transplantation. Some evidence shows that portions...
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Successful Immune Reconstitution in a Patient with a TYK2 Deficiency after Allogeneic Stem Cell Transplantation from Unrelated Donors
A boy with primary immunodeficiency, caused by a tyrosine kinase 2 ( TYK2 ) mutation, presented with immune defects and a lifelong history of severe...
