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Breast Tumor Microenvironment and CDKs
Breast malignancy is one of the most frequently diagnosed carcinoma in women globally, and it is also the common reason for tumor-associated fatality...
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Tumor Heterogeneity in Breast Cancer Progression
Cancer is an aberrant growth of cells with dynamic molecular changes as the disease progresses. As a result of these dynamic changes and an increase...
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Tumor Heterogeneity in Breast Cancer Progression
Cancer is an aberrant growth of cells with dynamic molecular changes as the disease progresses. As a result of these dynamic changes and an increase...
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Targeting tumor–stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model
Triple-negative breast cancer (TNBC) is highly aggressive with limited available treatments. Stromal cells in the tumor microenvironment (TME) are...
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Association of early menarche with breast tumor molecular features and recurrence
BackgroundEarly menarche is an established risk factor for breast cancer but its molecular contribution to tumor biology and prognosis remains...
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Circulating tumor DNA validity and potential uses in metastatic breast cancer
Following the first characterization of circulating tumor DNA (ctDNA) in the 1990s, recent advances led to its introduction in the clinics. At...
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CYD0281, a Bcl-2 BH4 domain antagonist, inhibits tumor angiogenesis and breast cancer tumor growth
BackgroundB-cell lymphoma 2 (Bcl-2) family proteins are key regulators of apoptosis, which possess four conserved Bcl-2 homologies (BH) domains....
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Modulation of the tumor microenvironment and mechanism of immunotherapy-based drug resistance in breast cancer
Breast cancer, the most frequent female malignancy, is often curable when detected at an early stage. The treatment of metastatic breast cancer is...
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The tumor-nerve circuit in breast cancer
It is well established that innervation is one of the updated hallmarks of cancer and that psychological stress promotes the initiation and...
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Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy
BackgroundBreast cancer neoadjuvant chemotherapy (NACT) allows for assessing tumor sensitivity to systemic treatment, planning adjuvant treatment and...
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Large language model (ChatGPT) as a support tool for breast tumor board
Large language models (LLM) such as ChatGPT have gained public and scientific attention. The aim of this study is to evaluate ChatGPT as a support...
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COPS6 promotes tumor progression and reduces CD8+ T cell infiltration by repressing IL-6 production to facilitate tumor immune evasion in breast cancer
Due to poor T cell infiltration, tumors evade immune surveillance. Increased CD8 + T cell infiltration in breast cancer suggests a satisfactory...
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DNA methylation age in paired tumor and adjacent normal breast tissue in Chinese women with breast cancer
BackgroundFew studies have examined epigenetic age acceleration (AA), the difference between DNA methylation (DNAm) predicted age and chronological...
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Hypofractionated radiotherapy with simultaneous tumor bed boost (Hi-RISE) in breast cancer patients receiving upfront breast-conserving surgery: study protocol for a phase III randomized controlled trial
BackgroundThe effectiveness and safety of moderately hypofractionated radiotherapy (HFRT) in patients undergoing breast-conserving surgery (BCS) has...
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Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer
BackgroundCarbonic anhydrases catalyze CO 2 /HCO 3 – buffer reactions with implications for effective H + mobility, pH dynamics, and cellular acid–base...
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Cancer-associated fibroblasts (CAFs) gene signatures predict outcomes in breast and prostate tumor patients
BackgroundOver the last two decades, tumor-derived RNA expression signatures have been developed for the two most commonly diagnosed tumors...
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Induced Current Electro-Thermal Imaging for Breast Tumor Detection: A Numerical and Experimental Study
This study proposes using magnetically induced currents in medical infrared imaging to increase the temperature contrast due to the electrical...
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The impact of tumor microenvironment: unraveling the role of physical cues in breast cancer progression
Metastasis accounts for the vast majority of breast cancer-related fatalities. Although the contribution of genetic and epigenetic modifications to...
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Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-𝜅B-IL-6 axis of tumor-associated macrophages
BackgroundCircular RNAs (circRNAs) have important regulatory functions in cancer, but the role of circRNAs in the tumor microenvironment (TME)...
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Crosstalk and plasticity driving between cancer-associated fibroblasts and tumor microenvironment: significance of breast cancer metastasis
Cancer-associated fibroblasts (CAFs) are the most abundant stromal cell population in breast tumors. A functionally diverse population of CAFs...
