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Anti-proliferative activity of RIHMS-Qi-23 against MCF-7 breast cancer cell line is through inhibition of cell proliferation and senescence but not inhibition of targeted kinases
BackgroundBreast cancer is the most common malignancy globally, and is considered a major cause of cancer-related death. Tremendous effort is exerted...
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Anti-cancer potential of substituted “amino-alkyl-rhodamine” derivatives against MCF-7 human breast cancer cell line
Breast cancer is the most prevalent diagnosed cancer among women and the main cause of morbidity and mortality. As for breast cancer, MCF-7 cells are...
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Targeting cholesterol impairs cell invasion of all breast cancer types
BackgroundBreast cancer clinical outcome relies on its intrinsic molecular subtype and mortality is almost exclusively due to metastasis, whose...
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linc01152 Regulates Cell Viability, Cell Migration and Cell Invasion of Breast Cancer via Regulating miR-320a and MTDH
Breast cancer is a global disease and a cause of cancer-related deaths in women. Long non-coding RNAs (lncRNAs) perform important functions in...
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Adipocyte–Breast Cancer Cell Co-Culture in Transwells
Experiments with cell co-culture systems facilitate investigation of the effects of one cell population on another, when the cells are grown in close...
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Cytotoxic evaluation of YSL-109 in a triple negative breast cancer cell line and toxicological evaluations
Breast cancer (BC) is the leading cause of cancer-related death in women worldwide. Triple negative breast cancer (TNBC) is the most aggressive form...
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Effect of Rosa damascena Essential Oil Loaded in Nanostructured Lipid Carriers on the Proliferation of Human Breast Cancer Cell Line MDA-MB-231 in Comparison with Cisplatin
PurposeAs Rosa damascena essential oils (RDEOs) have antioxidant, antibacterial, antiviral, and insecticidal activity, they could therefore be...
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Comparing the toxicity effects of copper oxide nanoparticles conjugated with Lapatinib on breast (MDA-MB-231) and lung (A549) cancer cell lines
In recent years, the increase in cancer morbidity and mortality has presented scientists with a major challenge in develo** new therapeutic agents...
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Predictability of B cell clonal persistence and immunosurveillance in breast cancer
B cells and T cells are important components of the adaptive immune system and mediate anticancer immunity. The T cell landscape in cancer is well...
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microRNA-944 inhibits breast cancer cell proliferation and promotes cell apoptosis by reducing SPP1 through inactivating the PI3K/Akt pathway
Breast cancer is a common malignancy in women with poor prognosis. This study aimed to investigate the molecular mechanism of microRNA-944 (miR-944)...
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Reduced representative methylome profiling of cell-free DNA for breast cancer detection
BackgroundWhole-genome methylation sequencing of cfDNA is not cost-effective for tumor detection. Here, we introduce reduced representative methylome...
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CDKs in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer
One of the deadly diseases in terms of incidence and mortality among females is breast cancer (BC), it is escalating at an alarming rate having...
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cGAS-STING pathway expression correlates with genomic instability and immune cell infiltration in breast cancer
Genomic instability, as caused by oncogene-induced replication stress, can lead to the activation of inflammatory signaling, involving the cGAS-STING...
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Resistance to Immunotherapy in Breast Cancer
Breast cancer is the most common and second most deadly disease in women worldwide, with breast cancer screening resulting in a steady decline in...
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Identification of lineage-specific epigenetic regulators FOXA1 and GRHL2 through chromatin accessibility profiling in breast cancer cell lines
Breast cancer is a heterogeneous disease, and breast cancer cell lines are invaluable for studying this heterogeneity. However, the epigenetic...
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Selective apoptotic and genotoxic effects of pomegranate peel extract against human hepatocellular carcinoma HepG2 cell line
Finding a therapeutic agent that is selective, non-toxic to normal cells, and does not develop resistance or unpleasant side effects became the most...
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COPS6 promotes tumor progression and reduces CD8+ T cell infiltration by repressing IL-6 production to facilitate tumor immune evasion in breast cancer
Due to poor T cell infiltration, tumors evade immune surveillance. Increased CD8 + T cell infiltration in breast cancer suggests a satisfactory...
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Immunotherapy in Breast Cancer
Breast cancer affects 12% of women worldwide. Although advances in systemic, surgical, and radiation therapy approaches will cure a large proportion...