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Cell-autonomous effect of cardiomyocyte branched-chain amino acid catabolism in heart failure in mice
Parallel to major changes in fatty acid and glucose metabolism, defect in branched-chain amino acid (BCAA) catabolism has also been recognized as a...
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BCAT1 promotes osteoclast maturation by regulating branched-chain amino acid metabolism
Branched-chain aminotransferase 1 (BCAT1) transfers the amine group on branched-chain amino acids (BCAAs) to alpha-ketoglutarate. This generates...
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The Association Between Branched-Chain Amino Acid Concentrations and the Risk of Autism Spectrum Disorder in Preschool-Aged Children
Several studies have linked branched-chain amino acid (BCAA) metabolism disorders with autism spectrum disorder (ASD), but the results have been...
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Characterization and application of a lactate and branched chain amino acid metabolism related gene signature in a prognosis risk model for multiple myeloma
BackgroundAbout 10% of hematologic malignancies are multiple myeloma (MM), an untreatable cancer. Although lactate and branched-chain amino acids...
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Inhibition of branched-chain alpha-keto acid dehydrogenase kinase augments the sensitivity of ovarian and breast cancer cells to paclitaxel
ContextMany cancer patients who initially respond to chemotherapy eventually develop chemoresistance, and to address this, we previously conducted a...
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Branched-chain amino acids (BCAA) administration increases autophagy and the autophagic pathway in brain tissue of rats submitted to a Maple Syrup Urine Disease (MSUD) protocol
Maple Syrup Urine Disease (MSUD) is an inborn error of metabolism (EIM) biochemically characterized by the tissue accumulation of branched-chain...
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Plasma branched-chain and aromatic amino acids correlate with the gut microbiota and severity of Parkinson’s disease
Disturbances of circulating amino acids have been demonstrated in patients with Parkinson’s disease (PD). However, there have been no consistent...
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Pancreatic cancer: branched-chain amino acids as putative key metabolic regulators?
Branched-chain amino acids (BCAA) are essential amino acids utilized in anabolic and catabolic metabolism. While extensively studied in obesity and...
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Evaluation of Branched-Chain Amino Acids in Children with Autism Spectrum Disorder and Epilepsy
Autism spectrum disorder (ASD) and epilepsy run hand-to-hand in their pathophysiology. Epilepsy is not an uncommon finding in patients with ASD. The...
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Neuroinflammatory responses following zinc or branched-chain amino acids supplementation in obese rats
The excessive production of pro-inflammatory mediators, characteristic of obesity, leads to neuroinflammation. Zinc (Zn) and the branched-chain amino...
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Predictive Ability of Serum Amino Acid Levels to Differentiate Fibromyalgia Patients from Healthy Subjects
BackgroundFibromyalgia is a complex illness to diagnose and treat.
ObjectivesTo evaluate a broad range of circulating free amino acid (AA) levels in...
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Genetic predisposition to impaired metabolism of the branched chain amino acids, dietary intakes, and risk of type 2 diabetes
Background and objectivesCirculating branched chain amino acids (BCAAs) increase the risk of type 2 diabetes (T2D). The genetic variants in the BCAA...
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Branched Short-Chain Fatty Acids as Biological Indicators of Microbiota Health and Links with Anthropometry
Bacterial metabolites are one of the main mechanisms of host-microbiota interactions in the gut. Acetate, propionate, and butyrate, also known as...
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Branched Short-Chain Fatty Acids as Biological Indicators of Microbiota Health and Links with Anthropometry
Bacterial metabolites are one of the main mechanisms of host-microbiota interactions in the gut. Acetate, propionate, and butyrate, also known as...
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Systemic perturbations in amino acids/amino acid derivatives and tryptophan pathway metabolites associated with murine influenza A virus infection
BackgroundInfluenza A virus (IAV) is the only influenza virus causing flu pandemics (i.e., global epidemics of flu disease). Influenza (the flu) is a...
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Transformation of the Amino Acid Pool in the Rat Brain under Conditions of Experimental Immunodeficiency
Abstract —The immune system, as one of the integrating general regulatory systems of the body, is in close relationship with the nervous and endocrine...
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Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity
Metabolic reprogramming of amino acids has been increasingly recognized to initiate and fuel tumorigenesis and survival. Therefore, there is emerging...
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Altered Metabolome of Amino Acids Species: A Source of Signature Early Biomarkers of T2DM
Diabetes mellitus is a chronic metabolic disease with serious health consequences for a modern civilization that often lead to premature death. With...
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MicroRNA-mediated reprogramming of glucose, fatty acid and amino acid metabolism in cancer
Cancer cells possess a unique metabolic phenotype, rewiring their metabolic pathways to support energy-intensive and biosynthetic requirements for...
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Amino acid profile alteration in age-related atrial fibrillation
BackgroundAmino acids (AAs) are one of the primary metabolic substrates for cardiac work. The correlation between AAs and both atrial fibrillation...
