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Mulberry branch fiber improved lipid metabolism and egg yolk fatty acid composition of laying hens via the enterohepatic axis
BackgroundThe utilization of mulberry branch fiber (MF), the largest by-product of the sericulture industry, is an important issue. Supplementation...
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Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity
Metabolic reprogramming of amino acids has been increasingly recognized to initiate and fuel tumorigenesis and survival. Therefore, there is emerging...
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Genome-Wide Identification and Comparative Analysis of Elongation of Very Long-Chain Fatty Acid (Elovl) Genes in Echinoderms
AbstractElongation of very long-chain fatty acid (Elovl) proteins is the critical rate-limiting enzyme that catalyzes the biosynthesis of long-chain...
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MicroRNA-mediated reprogramming of glucose, fatty acid and amino acid metabolism in cancer
Cancer cells possess a unique metabolic phenotype, rewiring their metabolic pathways to support energy-intensive and biosynthetic requirements for...
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The regulation of amino acid metabolism in tumor cell death: from the perspective of physiological functions
Amino acids (AAs) are crucial molecules for the synthesis of mammalian proteins as well as a source of energy and redox equilibrium maintenance. The...
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Pancreatic cancer: branched-chain amino acids as putative key metabolic regulators?
Branched-chain amino acids (BCAA) are essential amino acids utilized in anabolic and catabolic metabolism. While extensively studied in obesity and...
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Nucleic Acid-Based Micellar Therapy for the Treatment of Different Diseases
The theory of genetics is that branch of biology that deals with the study of genetic variation, genes, and heredity, and Gregor’s medals discovered...
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Sulfur amino acid restriction, energy metabolism and obesity: a study protocol of an 8-week randomized controlled dietary intervention with whole foods and amino acid supplements
BackgroundDietary sulfur amino acid (SAA) restriction is an established animal model for increasing lifespan and improving metabolic health. Data...
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Blue Emission of Tetrafluorobenzocarbazole Under the Interactions of Nitrogen–oxygen Saturated hydrogen Bonds with Aggregated Proton Acid
Two novel tetrafluorobenzocarbazole and containing the amino branch introduced at the end of the molecule are synthesized by a simple method. The...
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Identifying novel amino acid substitutions of hemagglutinin involved in virulence enhancement in H7N9 virus strains
BackgroundTo identify site-specific features of amino acid substitutions that confer enhanced H7N9 virulence in humans, we independently generated...
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Changes of the Concentration of Short-Chain Fatty Acids in the Intestines of Mice with Different Types of Obesity
We studied the production of short-chain fatty acids (SCFA) by the intestinal microbiota in mice with obesity caused by a diet and a genetic defect...
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Metabolic Rewiring in Cancer: Understanding the Complexity of Metabolic Networks
Cancer is characterized by uncontrolled cell growth and survival, which entails the reprogramming of metabolic pathways to generate energy and...
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Integrative analysis of the gut microbiota and faecal and serum short-chain fatty acids and tryptophan metabolites in patients with cirrhosis and hepatic encephalopathy
ObjectiveThe purpose of this study was to describe the changes in the gut microbiome of patients with cirrhosis and hepatic encephalopathy (HE), as...
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Metabolic Rewiring in Cancer: Understanding the Complexity of Metabolic Networks
Cancer is characterized by uncontrolled cell growth and survival, which entails the reprogramming of metabolic pathways to generate energy and...
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Amino Acids in Cell Signaling: Regulation and Function
Amino acids are the main building blocks for life. Aside from their roles in composing proteins, functional amino acids and their metabolites play...
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Potential Biomarkers of Mitochondrial Dysfunction Associated with COVID-19 Infection
Mitochondria play crucial roles in modulating immune responses, and viruses can in turn moderate mitochondrial functioning. Therefore, it is not...
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A Comprehensive Pilot Study to Elucidate the Distinct Gut Microbial Composition and Its Functional Significance in Cardio-Metabolic Disease
Cardio-metabolic disease is a significant global health challenge with increasing prevalence. Recent research underscores the disruption of gut...
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The Analyses of Cetacean Virus-Responsive Genes Reveal Evolutionary Marks in Mucosal Immunity-Associated Genes
Viruses are the most common and abundant organisms in the marine environment. To better understand how cetaceans have adapted to this virus-rich...
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Amino Acids in Endoplasmic Reticulum Stress and Redox Signaling
Proteins are the chains of amino acids linked via peptide bonds. In cells, newly synthesized proteins are modified and folded in the endoplasmic...
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Metabolite-Based Biosignature of Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic neoplasm and one of the leading causes of cancer-associated deaths. Lack of...