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Lessons on brain edema in HE: from cellular to animal models and clinical studies
Brain edema is considered as a common feature associated with hepatic encephalopathy (HE). However, its central role as cause or consequence of HE...
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Therapeutic Hypothermia Combined with Hydrogen Sulfide Treatment Attenuated Early Blood–Brain Barrier Disruption and Brain Edema Induced by Cardiac Arrest and Resuscitation in Rat Model
Brain injury remains a major problem in patients suffering cardiac arrest (CA). Disruption of the blood–brain barrier (BBB) is an important factor...
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Histone Deacetylase 3 Inhibition Decreases Cerebral Edema and Protects the Blood–Brain Barrier After Stroke
We have previously shown that selective inhibition of histone deacetylase 3 (HDAC3) decreases infarct volume and improves long-term functional...
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RAGE Inhibitors as Alternatives to Dexamethasone for Managing Cerebral Edema Following Brain Tumor Surgery
Resection of brain tumors frequently causes injury to the surrounding brain tissue that exacerbates cerebral edema by activating an inflammatory...
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Aquaporins in Edema
One of the most prevalent indications of water–electrolyte imbalance is edema. Aquaporins (AQPs) are a protein family that can function as water...
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MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and secondary brain edema in a mouse model of intracerebral hemorrhage
BackgroundThe functional neurological outcome of patients with intracerebral hemorrhage (ICH) strongly relates to the degree of secondary brain...
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Interactions of brain, blood, and CSF: a novel mathematical model of cerebral edema
BackgroundPrevious models of intracranial pressure (ICP) dynamics have not included flow of cerebral interstitial fluid (ISF) and changes in...
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Simulating Cerebral Edema and Ischemia After Traumatic Acute Subdural Hematoma Using Triphasic Swelling Biomechanics
Poor outcome following traumatic acute subdural hematoma (ASDH) is associated with the severity of the primary injury and secondary injury including...
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Post-stroke Impairment of the Blood–Brain Barrier and Perifocal Vasogenic Edema Is Alleviated by Endovascular Mesenchymal Stem Cell Administration: Modulation of the PKCδ/MMP9/AQP4-Mediated Pathway
Post-stroke edema and upregulation of aquaporin 4 (AQP4) water transport channels play a significant role in the progression of stroke pathology and...
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Clinical Effects of Piracetam Plus Mannitol on Cerebral Edema, Neurological Function, and Vascular Endothelin-1 Levels Following Cerebral Hemorrhage
AbstractThe effects of piracetam plus mannitol on cerebral edema, neurological function, and vascular endothelin-1 (ET-1) levels after cerebral...
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Upregulation of AQP4 Improves Blood–Brain Barrier Integrity and Perihematomal Edema Following Intracerebral Hemorrhage
In intracerebral hemorrhage (ICH), delayed secondary neural damages largely occur from perihematomal edema (PHE) resulting from the disruption of the...
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The role of the osmosensitive transcription factor NFAT5 in corneal edema resorption after injury
The osmosensitive transcription factor nuclear factor of activated T cells 5 (NFAT5; or tonicity-responsive enhancer binding protein; TonEBP) plays a...
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Chronic Kombucha Beverage Consumption Attenuates Inflammatory Markers and Histopathology of Brain Tissue in Transnet Global Brain Ischemia in Rats
There is evidence that kombucha beverage (KB), a traditional fermented beverage, has a preventive effect on experimental brain ischemia. According to...
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Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis
Sepsis-associated brain injury (SABI) is characterized by an acute deterioration of mental status resulting in cognitive impairment and acquisition...
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Systemic inflammatory markers of persistent cerebral edema after aneurysmal subarachnoid hemorrhage
BackgroundCerebral edema (CE) at admission is a surrogate marker of ‘early brain injury’ (EBI) after subarachnoid hemorrhage (SAH). Only recently has...
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Neurosteroid Receptor Modulators for Treating Traumatic Brain Injury
Traumatic brain injury (TBI) triggers wide-ranging pathology that impacts multiple biochemical and physiological systems, both inside and outside the...
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Texture Estimation for Abnormal Tissue Segmentation in Brain MRI
This chapter discusses multifractal texture estimation and characterization of brain lesions (necrosis, edema, enhanced tumor, nonenhanced tumor,...
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Piezo2 Contributes to Traumatic Brain Injury by Activating the RhoA/ROCK1 Pathways
Traumatic brain injury (TBI) can lead to short-term and long-term physical and cognitive impairments, which have significant impacts on patients,...
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Effect of osteoporotic conditions on the development of peritumoral brain edema after LINAC-based radiation treatment in patients with intracranial meningioma
PurposeDisruption of the tumor-brain barrier in meningioma is a crucial factor in peritumoral brain edema (PTBE). We previously reported the possible...
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Crosstalk Among Glial Cells in the Blood–Brain Barrier Injury After Ischemic Stroke
Blood–brain barrier (BBB) is comprised of brain microvascular endothelial cells (ECs), astrocytes, perivascular microglia, pericytes, neuronal...
