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Injectable systems of chitosan in situ forming composite gel incorporating linezolid-loaded biodegradable nanoparticles for long-term treatment of bone infections
The objective of the current study was to create an efficient, minimally invasive combined system comprising in situ forming hydrogel loaded with...
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Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice
The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed...
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Classification of Metal-Based Anticancer Chemotherapeutic Agents
3d metal-based chemotherapeutic agents are considered as the promising viable options for the treatment of solid malignancies as compared to...
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Bacterial Zoonotic Pathogens as Bioterroristic Agents
First reports on biological warfare date as early as the fourteenth century BC, while bioterrorism is a phenomenon of modern times. Bioterrorism...
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Natural Products as Antiparasitic, Antifungal, and Antibacterial Agents
The estimated age of 26.7 billion years of the universe was insufficient to explore its mysteries and hidden possibilities. As soon as humanity...
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The Effectiveness of Various Chemotherapeutic Agents in Cancer Treatment
Purpose of ReviewCancer is one of the most life-threatening disease worldwide. It affects people of all age groups. Various escape mechanisms...
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Natural Immunomodulatory Agents as a Complementary Therapy for Poxviruses
PoxvirusesPoxviruses target innate immunity mediators such as tumor necrosis factors, interleukins, interferons, complement, and chemokines. It also...
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Antileukemic effect of venetoclax and hypomethylating agents via caspase-3/GSDME-mediated pyroptosis
BackgroundThe identifying of B-cell lymphoma 2 (Bcl-2) as a therapeutic target has led to a paradigm shift in acute myeloid leukemia (AML) treatment....
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Bacterial Zoonotic Pathogens As Bioterroristic Agents
First reports on biological warfare date as early as the fourteenth century BC, while bioterrorism is a phenomenon of modern times. Bioterrorism...
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Narrative review on nanoparticles based on current evidence: therapeutic agents for diabetic foot infection
Diabetes’s effects on wound healing present a major treatment challenge and increase the risk of amputation. When traditional therapies fail, new...
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Sesquiterpenoid lactones as potential anti-cancer agents: an update on molecular mechanisms and recent studies
Plants-based natural compounds are well-identified and recognized chemoprotective agents that can be used for primary and secondary cancer...
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Synthesis and Pharmacological Evaluation of Novel Triazole-Pyrimidine Hybrids as Potential Neuroprotective and Anti-neuroinflammatory Agents
ObjectiveNeuroprotection is a precise target for the treatment of neurodegenerative diseases, ischemic stroke, and traumatic brain injury. Pyrimidine...
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Advances in Delivery of Chemotherapeutic Agents for Cancer Treatment
Presently, most of the treatment strategies for cancer are focused on the surgical removal of cancerous tumors, along with physical and chemical...
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Progress in discovery and development of natural inhibitors of histone deacetylases (HDACs) as anti-cancer agents
The study of epigenetic translational modifications had drawn great interest for the last few decades. These processes play a vital role in many...
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Therapeutic Applications of Snake Venom Proteins as Anti-cancer Agents
Cancer is a life debilitating fatal disease that affects millions of lives annually across the world. The current cancer treatments include invasive...
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Cationic Contrast Agents for Computed Tomography of Cartilage for Early Diagnosis of Osteoarthritis
Here we describe methods for synthesizing cationic contrast agents for computed tomography (CT) of cartilage for early diagnosis of tissue...
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Chorioallantoic Membrane (CAM) and In Ovo Models as Potential Platforms for Testing Cancer Agents
The construction of clinically related models for cancer metastasis and anticancer testing plays a significant role in evidence-based translational...
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Antimicrobial Agents in Agriculture and Their Implications in Antimicrobial Resistance
Antimicrobial resistance in living organisms is reaching its peak and leading to the imminent global disaster. Bacterial, fungal, and parasitic...
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Biopolymer-Based Nanocarriers for Stem Cells or Stem Cell Differentiating Agents and Their Therapeutic Significance
This chapter reviews the progress of our understanding on stem cells and their forward path to applications in tissue engineering. The various...
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Biopolymer-Based Nanocarriers for Stem Cells or Stem Cell Differentiating Agents and Their Therapeutic Significance
This chapter reviews the progress of our understanding on stem cells and their forward path to applications in tissue engineering. The various...