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Blood count changes in malaria patients according to blood groups (ABO/Rh) and sickle cell trait
IntroductionIntroduction: Malaria continues to be the leading cause of hospitalization and death in Angola, a country in sub- Saharan Africa. In...
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Profiling of T cell repertoire in peripheral blood of patients from type 2 diabetes with complication
PurposeMore than 90% of patients with diabetes worldwide are type 2 diabetes (T2D), which is caused by insulin resistance or impaired producing...
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An Automated Method for Blood Type Determination by Red Blood Cell Agglutination Assay
A new automated method for assaying specific agglutination of red blood cells upon addition of monoclonal antibodies to whole blood test samples is...
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Epigenomic profiling of isolated blood cell types reveals highly specific B cell smoking signatures and links to disease risk
BackgroundTobacco smoking alters the DNA methylation profiles of immune cells which may underpin some of the pathogenesis of smoking-associated...
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Red blood cell distribution width is associated with sarcopenia risk in early-stage non-small cell lung cancer
BackgroundSarcopenia has received increasing attention in non-small cell lung cancer (NSCLC). Red blood cell distribution width (RDW) is a...
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Umbilical cord blood and cord tissue banking as somatic stem cell resources to support medical cell modalities
Human umbilical cord blood (CB) and umbilical cord tissue (UC) are attractive sources of somatic stem cells for gene and cell therapies. CB and UC...
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Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function
Spleen marginal zone (MZ) B cells are important for antibody responses against blood-borne antigens. The signals they use to detect exposure to blood...
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Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood–brain barrier impairment
Cerebral small vessel disease is characterised by decreased cerebral blood flow and blood–brain barrier impairments which play a key role in the...
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Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke
Cerebral ischemia triggers a powerful inflammatory reaction involving peripheral leukocytes and brain resident cells that contribute to both tissue...
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Blood cell parameters and risk of nonalcoholic fatty liver disease: a comprehensive Mendelian randomization study
BackgroundNonalcoholic fatty liver disease (NAFLD) is on the rise globally, and past research suggests a significant association with various blood...
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Red blood cell-derived arginase release in hemolytic uremic syndrome
BackgroundHemolysis is a cardinal feature of hemolytic uremic syndrome (HUS) and during hemolysis excess arginase 1 is released from red blood cells....
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In vitro model of brain endothelial cell barrier reveals alterations induced by Plasmodium blood stage factors
Cerebral malaria (CM) is a severe neurological condition caused by Plasmodium falciparum . Disruption of the brain-blood barrier (BBB) is a key...
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Differential Cytokine Responses of APOE3 and APOE4 Blood–brain Barrier Cell Types to SARS-CoV-2 Spike Proteins
SARS-CoV-2 spike proteins have been shown to cross the blood–brain barrier (BBB) in mice and affect the integrity of human BBB cell models. However,...
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Post-therapeutic circulating tumor cell-associated white blood cell clusters predict poor survival in patients with advanced driver gene-negative non-small cell lung cancer
PurposeThis study aimed to investigate the clinical utility of diverse aneuploid circulating tumor cell (CTC) subtypes and particularly...
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Single-cell transcriptomic profiling reveals immune cell heterogeneity in acute myeloid leukaemia peripheral blood mononuclear cells after chemotherapy
PurposeAcute myeloid leukaemia (AML) is a heterogeneous disease characterised by the rapid clonal expansion of abnormally differentiated myeloid...
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Isolation of tumour-reactive lymphocytes from peripheral blood via microfluidic immunomagnetic cell sorting
The clinical use of tumour-infiltrating lymphocytes for the treatment of solid tumours is hindered by the need to obtain large and fresh tumour...
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External validation of a red cell-based blood prognostic score in patients with metastatic renal cell carcinoma treated with first-line immunotherapy combinations
Immunotherapy combinations with tyrosine-kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) had significantly improved outcomes of...
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Using R for Cell-Type Composition Imputation in Epigenome-Wide Association Studies
Adjusting cell type composition is challenging but critical in epigenome-wide association studies (EWAS). In this chapter, we describe how to apply...
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Optimization of Peripheral Blood Mononuclear Cell Processing for Improved Clinical ELISpot Assay Performance
Cell and gene therapies have demonstrated impressive therapeutic efficacy in various human diseases. Nevertheless, cellular immune response directed...
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Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss
Intraocular pressure (IOP) is currently the only modifiable risk factor for glaucoma and all licensed treatments lower IOP. However, many patients...
