Search
Search Results
-
Blood DNA methylation signatures of lifestyle exposures: tobacco and alcohol consumption
BackgroundSmoking and alcohol consumption may compromise health by way of epigenetic modifications. Epigenetic signatures of alcohol and tobacco...
-
Biomarkers of Alcohol Toxicity
The aim of this review is to explore the current understanding of the mechanisms and course of alcohol intoxication, in particular by discussing the...
-
Cytokine Production in Whole Blood Cells Culture of Patients with Alcohol Dependence and Autologous Plasma Oxidative Stress Markers
We studied spontaneous production of a spectrum of proinflammatory cytokines by cultured whole blood cells from men with alcohol dependence at the...
-
Alcohol: Neurobiology of Alcohol Addiction
Consumption of alcohol is the third leading cause of preventable deaths worldwide making it a major public health issue. After a brief account of the...
-
Alcohol and the Cerebellum
Alcohol (EtOH) is a socially accepted and widely used psychoactive compound, derived from the fermentation/distillation of various plant sugars....
-
Blood vessel remodeling in the cerebral cortex induced by binge alcohol intake in mice
Ethanol is toxic to the brain and causes various neurological disorders. Although ethanol can directly exert toxicity on neurons, it also acts on...
-
Consuming oral cannabidiol prior to a standard alcohol dose has minimal effect on breath alcohol level and subjective effects of alcohol
RationaleCannabidiol (CBD) is found in the cannabis plant and has garnered attention as a potential treatment for alcohol use disorder (AUD). CBD...
-
An overview of current advances in perinatal alcohol exposure and pathogenesis of fetal alcohol spectrum disorders
The adverse use of alcohol is a serious global public health problem. Maternal alcohol consumption during pregnancy usually causes prenatal alcohol...
-
Effect of the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide on alcohol consumption in alcohol-preferring male vervet monkeys
RationaleGlucagon-like peptide-1 (GLP-1) receptor agonists reduce alcohol consumption in rodents and non-human primates. Semaglutide is a new...
-
Validating biomarkers and models for epigenetic inference of alcohol consumption from blood
BackgroundInformation on long-term alcohol consumption is relevant for medical and public health research, disease therapy, and other areas....
-
Subjective response to alcohol in young adults with bipolar disorder and recent alcohol use: a within-subject randomized placebo-controlled alcohol administration study
Limited data exists on mechanisms contributing to elevated risk for alcohol use disorder (AUD) in bipolar disorder. Variation in subjective response...
-
Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder
RationaleChronic alcohol intake down-regulates GABAergic transmission and reduces levels of neuroactive steroids. These changes are associated with...
-
Disentangling between- and within-person alcohol and expectancy effects on acute alcohol craving
ObjectiveAlcohol craving is a predictor of continued drinking and a diagnostic criterion for alcohol use disorder. Rewarding subjective effects...
-
Alcohol availability during withdrawal gates the impact of alcohol vapor exposure on responses to alcohol cues
RationaleChronic intermittent ethanol (CIE) vapor inhalation is a widely used model of alcohol dependence, but the impact of CIE on cue-elicited...
-
Details in Conducting Human Laboratory Alcohol Administration and Self-Administration Experiments to Assess Subjective Response and Craving for Alcohol
Human laboratory methods are valuable approaches to studying the etiology of alcohol misuse and interventions to ameliorate misuse because they offer...
-
Intravenous Alcohol Self-Administration Using a Progressive Ratio Schedule of Reinforcement in Clinical Studies
Operant self-administration paradigms are commonly used in preclinical and clinical studies as a way to experimentally observe individuals’ alcohol...
-
Short-chain fatty acid valerate reduces voluntary alcohol intake in male mice
BackgroundDespite serious health and social consequences, effective intervention strategies for habitual alcohol binge drinking are lacking. The...
-
Fetal Alcohol Syndrome
Maternal alcohol consumption during pregnancy is known to produce a spectrum of morphological and neurocognitive outcomes in the offspring. The most...
-
Biomarkers of Alcohol Toxicity
The aim of this review is to explore the current understanding of the mechanisms and course of alcohol intoxication, in particular by discussing the...
-
Endpoints for Pharmacotherapy Trials for Alcohol Use Disorder
Alcohol use disorder (AUD) is a debilitating disorder, yet currently approved pharmacotherapies to treat AUD are under-utilized. The three...