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Adjusting to Your Surroundings: An Inquiry-Based Learning Module to Teach Principles of Mechanobiology for Regenerative Medicine
Mechanobiology is an interdisciplinary field that aims to understand how physical forces impact biological systems. Enhancing our knowledge of...
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Teaching Tissue Repair Through an Inquiry-Based Learning Bioadhesives Module
Bioadhesives are an important class of biomaterials for wound healing, hemostasis, and tissue repair. To develop the next generation of bioadhesives,...
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Phantom study of layered sensor module for photon-counting BMD detector
In this study, we perform bone mineral density (BMD) calculation by designing a layered sensor module (LSM) that divides high- and low-energy spectra...
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Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry
Ancestral differences in genomic variation affect the regulation of gene expression; however, most gene expression studies have been limited to...
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Discovery of a genetic module essential for assigning left–right asymmetry in humans and ancestral vertebrates
The vertebrate left–right axis is specified during embryogenesis by a transient organ: the left–right organizer (LRO). Species including fish,...
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Reproducibility of Systolic Strain in Mice Using Cardiac Magnetic Resonance Feature Tracking of Black-Blood Cine Images
PurposeMouse models are widely utilized to enhance our understanding of cardiac disease. The goal of this study is to investigate the reproducibility...
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A simulation-based module in pharmacology education reveals and addresses medical students’ deficits in leading prescription talks
Although doctor-patient communication is essential for drug prescription, the literature reveals deficits in this area. An educational approach at...
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Inhibitory mechanism of angiotensin-converting enzyme inhibitory peptides from black tea
The aim of this work is to discover the inhibitory mechanism of tea peptides and to analyse the affinities between the peptides and the...
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BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis
Trimethylated histone H3 lysine 27 (H3K27me3) regulates gene repression, cell-fate determination and differentiation. We report that a conserved...
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Discovery of potential epidermal growth factor receptor inhibitors from black pepper for the treatment of lung cancer: an in-silico approach
A tyrosine kinase receptor known as epidermal growth factor receptor (EGFR) is one of the main tumour markers in many cancer types and also plays a...
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A positively charged surface patch on the pestivirus NS3 protease module plays an important role in modulating NS3 helicase activity and virus production
Pestivirus nonstructural protein 3 (NS3) is a multifunctional protein with protease and helicase activities that are essential for virus replication....
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Development of the Pediatric Quality of Life Inventory™ Spinal Cord Injury (PedsQL™ SCI) module: qualitative methods
Study designIt is a qualitative study.
ObjectivesTo develop the items and support content validity for the Pediatric Quality of Life Inventory™...
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Identification of Novel Prognostic Long Non-coding RNAs in Lung Adenocarcinoma Using WGCNA Analysis
Long non-coding RNAs play crucial role in the tumorigenesis of lung adenocarcinoma (LUAD). However, the function of a large number of lncRNAs in LUAD...
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Network Module Detection to Decipher Heterogeneity of Cancer Mutations
The analysis of genomic landscapes of cancer patients taken from large-scale datasets revealed the complexity and heterogeneity of the disease....
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AEAU-Net: an unsupervised end-to-end registration network by combining affine transformation and deformable medical image registration
AbstractDeformable medical image registration plays an essential role in clinical diagnosis and treatment. However, due to the large difference in...
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Impact of Tissue Damage and Hemodynamics on Restenosis Following Percutaneous Transluminal Angioplasty: A Patient-Specific Multiscale Model
Multiscale agent-based modeling frameworks have recently emerged as promising mechanobiological models to capture the interplay between biomechanical...
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Skip connection information enhancement network for retinal vessel segmentation
AbstractMany major diseases of the retina often show symptoms of lesions in the fundus of the eye. The extraction of blood vessels from retinal...
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PSMC6 induces immune cell infiltration and inflammatory response to aggravate primary Sjögren’s syndrome
Increasing evidence suggests that immune cell infiltration is involved in primary Sjögren’s syndrome (pSS), while the underlying molecular mechanisms...
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Diagnosis of pulmonary tuberculosis with 3D neural network based on multi-scale attention mechanism
This paper presents a novel multi-scale attention residual network (MAResNet) for diagnosing patients with pulmonary tuberculosis (PTB) by computed...
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Transcriptomic responses of cumulus granulosa cells to SARS-CoV-2 infection during controlled ovarian stimulation
Cumulus granulosa cells (CGCs) play a crucial role in follicular development, but so far, no research has explored the impact of SARS-CoV-2 infection...
