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Biomarkers for Bipolar Disorder
Biomarkers offer compelling promise to better understand bipolar disorder and identify effective treatments. With a lifetime prevalence of 2.5%, it...
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Deregulation of NF-κB associated long non-coding RNAs in bipolar disorder
Long non-coding RNAs (lncRNAs) are major genetic factors whose disruption lead to many diseases, including nervous system diseases. Bipolar disorder...
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Cerebellar Pathology in Schizophrenia, Bipolar Disorder, and Major Depression
Schizophrenia and mood disorders are severe psychiatric disorders with significant morbidity and mortality. Both disorders share high genetic and...
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Clozapine but not lithium reverses aberrant tyrosine uptake in patients with bipolar disorder
RationaleAvailability of the dopamine and noradrenaline precursor tyrosine is critical for normal functioning, and deficit in tyrosine transport...
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Hemorrhoidal disease and its genetic association with depression, bipolar disorder, anxiety disorders, and schizophrenia: a bidirectional mendelian randomization study
BackgroundHemorrhoids and psychiatric disorders exhibit high prevalence rates and a tendency for relapse in epidemiological studies. Despite this,...
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Progress and Implications from Genetic Studies of Bipolar Disorder
With the advancements in gene sequencing technologies, including genome-wide association studies, polygenetic risk scores, and high-throughput...
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Electroconvulsive therapy improves hematological inflammatory markers in bipolar disorder
BackgroundImmune dysfunction and inflammation participate in the pathophysiology of bipolar disorder (BD). Abnormal levels of inflammatory markers,...
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Glial-Neuronal Interaction in Synapses: A Possible Mechanism of the Pathophysiology of Bipolar Disorder
Bipolar disorder (BD) is a severe and chronic psychiatric disorder that affects approximately 1–4% of the world population and is characterized by...
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Sleep in Bipolar Disorders
Sleep disorders are ubiquitous across all phases of bipolar affective disorder (BPAD). Symptoms involving sleep are seen across all age group of...
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Abnormal expression of long non-coding RNAs RMRP, CTC-487M23.5, and DGCR5 in the peripheral blood of patients with Bipolar disorder
Long non-coding RNAs (lncRNAs) have been recently considered as one of the regulatory mechanisms of the nervous system. Hence, lncRNAs may be...
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TLR4 Polymorphisms (T399I/D299G) Association with Schizophrenia and Bipolar Disorder in a Tunisian Population
Immune dysregulation has been widely described in the pathophysiology of schizophrenia (SCZ) and bipolar disorder (BD). Particularly, TLR4-altered...
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Abelson Helper Integration Site 1 haplotypes and peripheral blood expression associates with lithium response and immunomodulation in bipolar patients
RationaleIn bipolar disorder (BD), immunological factors play a role in the pathogenesis and treatment of the illness. Studies showed the potential...
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HERV-W upregulation expression in bipolar disorder and schizophrenia: unraveling potential links to systemic immune/inflammation status
BackgroundBipolar disorder (BD) and schizophrenia (SZ) are the two main mental disorders with unknown etiology that significantly impact individuals’...
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Multiple-timescale dynamics, mixed mode oscillations and mixed affective states in a model of bipolar disorder
Mixed affective states in bipolar disorder (BD) is a common psychiatric condition that occurs when symptoms of the two opposite poles coexist during...
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Neurobiology of Bipolar Disorder
When you’re high, it’s tremendous. The ideas and feelings are fast and frequent like shooting stars, and you follow them until you find better and...
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Neurobiology of Bipolar Disorder
When you’re high, it’s tremendous. The ideas and feelings are fast and frequent like shooting stars, and you follow them until you find better and...
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Sensitization of ON-bipolar cells with ambient light activatable multi-characteristic opsin rescues vision in mice
Gene therapy-based treatment such as optogenetics offers a potentially powerful way to bypass damaged photoreceptors in retinal degenerative diseases...
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Shared genetic effect of kidney function on bipolar and major depressive disorders: a large-scale genome-wide cross-trait analysis
BackgroundEpidemiological studies have revealed a significant association between impaired kidney function and certain mental disorders, particularly...
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Genetics of bipolar disorder: insights into its complex architecture and biology from common and rare variants
Bipolar disorder (BD) is a common mental disorder characterized by recurrent mood episodes, which causes major socioeconomic burdens globally. Though...
