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Anticipated reactions to learning Alzheimer’s disease biomarker results
IntroductionWe developed the Alzheimer’s Biomarker Survey to assess willingness to enroll in biomarker studies that disclose results and anticipated...
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Applications of Nanotechnology in Converging the Biomarker Science for Advancement in Cancer Detection and Treatment
Cancer biomarkers with high selectivity, specificity, and reproducibility assume fundamental task in diagnosis, prognosis, and prediction of therapy...
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Applications of Nanotechnology in Converging the Biomarker Science for Advancement in Cancer Detection and Treatment
Cancer biomarkers with high selectivity, specificity, and reproducibility assume fundamental task in diagnosis, prognosis, and prediction of therapy...
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Quantitative Evaluation of Stance as a Sensitive Biomarker of Postural Ataxia Development in Preclinical SCA1 Mutation Carriers
The aim of this study was to determine the time between the first detection of postural control impairments and the evident manifestation of ataxia...
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Ethical Considerations in Communicating Alzheimer’s Disease Neuroimaging Biomarker Test Results to Symptomatic Individuals
This article examines ethical issues associated with the return of AD neuroimaging results to cognitively symptomatic individuals. Following a review...
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Considerations regarding a diagnosis of Alzheimer’s disease before dementia: a systematic review
BackgroundThe NIA-AA research framework proposes a purely biological definition of Alzheimer’s disease (AD). This implies that AD can be diagnosed...
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Practices and opinions about disclosure of the diagnosis of Alzheimer’s disease to patients with MCI or dementia: a survey among Belgian medical experts in the field of dementia
Previous surveys revealed that only a minority of clinicians routinely disclosed the diagnosis of Alzheimer’s disease (AD) to their patients. Many...
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PODN is a prognostic biomarker and correlated with immune infiltrates in osteosarcoma
BackgroundOsteosarcoma was the most common primary bone malignancy in children and adolescents. It was imperative to identify effective prognostic...
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Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer
BackgroundPDE9A (Phosphodiesterase 9A) plays an important role in proliferation of cells, their differentiation and apoptosis via intracellular cGMP...
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Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting
Alzheimer’s disease (AD), the most common form of dementia, remains challenging to understand and treat despite decades of research and clinical...
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The emerging role of exosomal miRNAs as a diagnostic and therapeutic biomarker in Mycobacterium tuberculosis infection
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), has been the world’s driving fatal bacterial contagious disease globally. It continues...
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Apolipoprotein E in Alzheimer’s disease trajectories and the next-generation clinical care pathway
Alzheimer’s disease (AD) is a complex, progressive primary neurodegenerative disease. Since pivotal genetic studies in 1993, the ε4 allele of the...
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Biomarkers for Cancer Drug Development
Cancer biomarkers, which are indicators of cancer cells in the body, can help with diagnosis, prognosis, and treatment effectiveness as well as...
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IL-8 as a potential biomarker in Guillain-Barre Syndrome
This pilot study was designed to compare the levels of interleukin-8 (IL-8), a pro-inflammatory chemokine, in the cerebrospinal fluid (CSF) of...
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Research Data Resources for Epidemiology
This chapter introduces the data landscape that enables access to data resources for researching in the field of epidemiology. The chapter covers a...
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Correlative studies of the Breast Cancer Index (HOXB13/IL17BR) and ER, PR, AR, AR/ER ratio and Ki67 for prediction of extended endocrine therapy benefit: a Trans-aTTom study
BackgroundMultiple clinical trials demonstrate consistent but modest benefit of adjuvant extended endocrine therapy (EET) in HR + breast cancer...
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Application of Metabolomics for the Discovery of Potent Antimicrobials from Plants
One of the major goals of studying metabolome and metabolism has long been to find biomarkers for disease diagnosis and prognosis. The significance...
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Association of mTOR Pathway and Conformational Alterations in C-Reactive Protein in Neurodegenerative Diseases and Infections
Inflammatory biomarkers have been very useful in detecting and monitoring inflammatory processes along with providing helpful information to select...
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Dementia risk communication. A user manual for Brain Health Services—part 3 of 6
Growing evidence suggests dementia incidence can be reduced through prevention programs targeting risk factors. To accelerate the implementation of...
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Investigation of urinary volatile organic compounds as novel diagnostic and surveillance biomarkers of bladder cancer
BackgroundThe diagnosis and surveillance of urothelial bladder cancer (UBC) require cystoscopy. There is a need for biomarkers to reduce the...
