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Imaging bioluminescence by detecting localized haemodynamic contrast from photosensitized vasculature
Bioluminescent probes are widely used to monitor biomedically relevant processes and cellular targets in living animals. However, the absorption and...
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In Vivo Bioluminescence and Fluorescence Imaging: Optical Tool for Cancer Research
In vivo whole-body imaging, using optical tools based on bioluminescence and fluorescence detection, offers tremendous opportunities to specifically...
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Bioluminescence-Optogenetics
In this chapter, we introduce a relatively new, emerging method for molecular neuromodulation—bioluminescence-optogenetics....
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Using Bioluminescence to Image Candida glabrata Urinary Tract Infections in Mice
The human fungal pathogen Candida glabrata is less virulent compared to the most isolated Candida species including Candida albicans. Its reduced...
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In Vivo Bioluminescence for the Detection of the Fate of Pancreatic Islet Organoids Post-transplantation
Pancreatic islet transplantation is a promising cell replacement treatment for patients afflicted with type 1 diabetes (T1D), which is an autoimmune...
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Comparison of ex vivo bioluminescence imaging, Alu-qPCR and histology for the quantification of spontaneous lung and bone metastases in subcutaneous xenograft mouse models
Bioluminescence imaging (BLI) is a non-invasive state-of-the-art-method for longitudinal tracking of tumor cells in mice. The technique is commonly...
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Quantitative Bioluminescence Tomography for In Vivo Volumetric-Guided Radiotherapy
Several groups, including ours, have initiated efforts to develop small-animal irradiators that mimic radiation therapy (RT) for human treatment. The...
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Bioluminescence Imaging, a Powerful Tool to Assess Fungal Burden in Live Mouse Models of Infection
Aspergillus fumigatus and Cryptococcus neoformans species infections are two of the most common life-threatening fungal infections in the...
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Using adenosine triphosphate bioluminescence level monitoring to identify bacterial reservoirs during two consecutive Enterococcus faecium and Staphylococcus capitis nosocomial infection outbreaks at a neonatal intensive care unit
IntroductionThis study aimed to assess the role of adenosine triphosphate (ATP) bioluminescence level monitoring for identifying reservoirs of the...
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Investigation of bioluminescence-based assays for determination of kinetic parameters for the bifunctional Neisseria meningitidis serogroup W capsule polymerase
ObjectiveNeisseria meningitidis is a Gram-negative bacterium that causes meningitis. N. meningitidis serogroup W ( Nm W) capsule polymerase...
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Visualization of activity-regulated BDNF expression in the living mouse brain using non-invasive near-infrared bioluminescence imaging
Altered levels of brain-derived neurotrophic factor (BDNF) have been reported in neurologically diseased human brains. Therefore, it is important to...
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Enhanced Bystander BRET (ebBRET) Biosensors as Biophysical Tools to Map the Signaling Profile of Neuropsychiatric Drugs Targeting GPCRs
Bioluminescence resonance energy transfer (BRET) is a non-radiative energy transfer between a bioluminescent donor and a fluorescent acceptor with...
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Repeat or single-dose lentiviral vector administration to mouse lungs? It’s all about the timing
Lentiviral vectors are attractive delivery vehicles for cystic fibrosis gene therapy owing to their low immunogenicity and ability to integrate into...
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Effects of radiofrequency field exposure on proteotoxic-induced and heat-induced HSF1 response in live cells using the bioluminescence resonance energy transfer technique
As of today, only acute effects of RF fields have been confirmed to represent a potential health hazard and they are attributed to non-specific...
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Real-Time Noninvasive Bioluminescence, Ultrasound and Photoacoustic Imaging in NFκB-RE-Luc Transgenic Mice Reveal Glia Maturation Factor-Mediated Immediate and Sustained Spatio-Temporal Activation of NFκB Signaling Post-Traumatic Brain Injury in a Gender-Specific Manner
Neurotrauma especially traumatic brain injury (TBI) is the leading cause of death and disability worldwide. To improve upon the early diagnosis and...
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In Vivo Imaging of Nipah Virus Infection in Small Animal Rodent Models
In vivo imaging system (IVIS) is a powerful tool for the study of infectious diseases, providing the ability to non-invasively follow viral infection...
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Repeated closed-head mild traumatic brain injury-induced inflammation is associated with nociceptive sensitization
BackgroundIndividuals who have experienced mild traumatic brain injuries (mTBIs) suffer from several comorbidities, including chronic pain. Despite...
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In Vivo Imaging of Naked and Microencapsulated Islet Cell Transplantation
We describe step-by-step methods to label human pancreatic islet cells and murine insulinoma cells and their subsequent transplantation into type I...
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Bioluminescence Methodology for Ion Channel Studies
As key players in cell function, ion channels are important targets for drug discovery and therapeutic development against a wide range of health...