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Bioinformatic Analysis of the Significance of the KIR2DL4 Gene in Recurrent Implantation Failure
Related studies have pointed out that Killer immunoglobulin-like receptor 2DL4 (KIR2DL4) was associated with vascular remodeling in early pregnancy,...
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Network-Based Data Analysis Reveals Ion Channel-Related Gene Features in COVID-19: A Bioinformatic Approach
Coronavirus disease 2019 (COVID-19) seriously threatens human health and has been disseminated worldwide. Although there are several treatments for...
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Bioinformatic Analysis of miR-200b/429 and Hub Gene Network in Cervical Cancer
The miR-200b/429 located at 1p36 is a highly conserved miRNA cluster emerging as a critical regulator of cervical cancer. Using publicly available...
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Gene expression analysis reveals diabetes-related gene signatures
BackgroundDiabetes is a spectrum of metabolic diseases affecting millions of people worldwide. The loss of pancreatic β-cell mass by either...
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Preconditioning exercise reduces brain damage of ischemic stroke in rats via PI3K–AKT pathway by bioinformatic analysis
Ischemic stroke is one of the most vital causes of high neurological morbidity and mortality in the world. Preconditioning exercise is considered as...
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Signaling Regulation of Human MSC Osteogenic Differentiation: Metanalysis and Bioinformatic Analysis of MicroRNA Impact
Numerous experimental data shows crucial involvement of mirs in skeletal development in embryos, osteogenic differentiation, and maturation. However,...
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Bioinformatic and literature assessment of toxicity and allergenicity of a CRISPR-Cas9 engineered gene drive to control Anopheles gambiae the mosquito vector of human malaria
BackgroundPopulation suppression gene drive is currently being evaluated, including via environmental risk assessment (ERA), for malaria vector...
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Identification of novel genes in Behcet’s disease using integrated bioinformatic analysis
Behcet’s disease (BD) is a chronic vascular inflammatory disease. However, the etiology and molecular mechanisms underlying BD development have not...
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mRNA markers for survival prediction in glioblastoma multiforme patients: a systematic review with bioinformatic analyses
BackgroundGlioblastoma multiforme (GBM) is a type of fast-growing brain glioma associated with a very poor prognosis. This study aims to identify key...
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Integrated Bioinformatic Analysis Reveals the Oncogenic, Survival, and Prognostic Characteristics of TPX2 in Hepatocellular Carcinoma
Targeting protein for Xenopus kinesin-like protein 2 (TPX2), a well-known mitotic protein, has been linked to carcinogenesis in several cancers. This...
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Translating Ribosome Affinity Purification (TRAP) and Bioinformatic RNA-Seq Analysis in Post-metamorphic Xenopus laevis
Recent technical advances provide the ability to isolate and purify mRNAs from genetically distinct cell types so as to provide a broader view of...
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Estimation of the impact of three different bioinformatic pipelines on sheep nemabiome analysis
BackgroundNext-generation sequencing (NGS) has provided an alternative strategy to study the composition of nematode communities with increased...
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Erratum to: Bioinformatic analysis for potential biological processes and key targets of heart failure-related stroke
The original version of this article (Liu et al., 2021) unfortunately contained a mistake: statement of equal contribution is missing. This...
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Sample Preparation and Differential Gene Expression Analysis of Human Cancer Cell Lines by RNA Sequencing
RNA sequencing (RNA-seq) is a method used for the high-throughput quantification of mRNA in a biological sample. It is widely used to investigate...
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Ribosomal RNA Transcription Machineries in Intestinal Protozoan Parasites: A Bioinformatic Analysis
PurposeRibosome biogenesis is a key process in all living organisms, energetically expensive and tightly regulated. Currently, little is known about...
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Identifying hub genes of sepsis-associated and hepatic encephalopathies based on bioinformatic analysis—focus on the two common encephalopathies of septic cirrhotic patients in ICU
BackgroundIn the ICU ward, septic cirrhotic patients are susceptible to suffering from sepsis-associated encephalopathy and/or hepatic...
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Bioinformatic analysis identifying FGF1 gene as a new prognostic indicator in clear cell Renal Cell Carcinoma
BackgroundClear cell renal cell carcinoma (ccRCC) has been the commonest renal cell carcinoma (RCC). Although the disease classification, diagnosis...
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In Silico Functional and Structural Analysis of Non-synonymous Single Nucleotide Polymorphisms (nsSNPs) in Human Paired Box 4 Gene
In human genome, members of Paired box (PAX) transcription factor family are highly sequence-specific DNA-binding proteins. Among PAX gene family...
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Bioinformatic Analysis of Natively Paired VH:VL Antibody Repertoires for Antibody Discovery
Next-generation DNA sequencing (NGS) of human antibody repertoires has been extensively implemented to discover novel antibody drugs, to analyze...
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Comprehensive bioinformatic analysis reveals a cancer-associated fibroblast gene signature as a poor prognostic factor and potential therapeutic target in gastric cancer
BackgroundGastric cancer is one of the deadliest cancers, currently available therapies have limited success. Cancer-associated fibroblasts (CAFs)...
