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Design and Evaluation of Sustained Release Bilayer Tablets of Oxcarbazepine
ObjectiveThe aim of the present study is to modify the release profile of oxcarbazepine by formulating it as a bilayer tablet using direct...
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Fabrication and Evaluation of Differential Release Bilayer Tablets of Clarithromycin and Levofloxacin by 3D Printing
PurposeFormulation of customized drug delivery systems is considered as an effective approach to fulfill the individualized needs of the patients.
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Bilayer tablets with sustained-release metformin and immediate-release sitagliptin: preparation and in vitro/in vivo evaluation
PurposeDiabetes mellitus, especially type II, is one of the most common chronic diseases. Its first-line oral treatment is metformin, commonly in...
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Preformulation and evaluation of multi-layer tablets
BackgroundThe tablet is the most common drug formulation in the pharmaceutical industry. With the invention of new pharmaceutical tablet compression...
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Development, Physicochemical Characteristics and Pharmacokinetics of a New Sustained-Release Bilayer Tablet Formulation of Tramadol with an Immediate-Release Component for Twice-Daily Administration
Background and ObjectiveThere are some potential concerns about the currently marketed solid oral dosage forms of tramadol, including decreased...
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A Review on Physicochemical Properties of Polymers Used as Filaments in 3D-Printed Tablets
Three-dimensional (3D) printing technology has presently been explored widely in the field of pharmaceutical research to produce various conventional...
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Use of Eudragit RS PO, HPMC K100M, Ethyl Cellulose, and Their Combination for Controlling Nicorandil Release from the Bilayer Tablets with Atorvastatin as an Immediate-Release Layer
PurposeTo develop a bilayer tablet containing sustained-release (SR) nicorandil and immediate-release (IR) atorvastatin components in separate layers...
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Quality by Design (QbD) Concept for Formulation of Oral Formulations for Tablets
Pharmaceutical scientists use the Quality by Design (QbD) approach to develop robust oral dosage forms, such as tablets and pellets, by considering...
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Risk Assessment and QbD-Based Optimization of Sorafenib Tosylate Colon Targeted Bilayer Tablet: In Vitro Characterization, In Vivo Pharmacokinetic, and In Vivo Roentgenography Studies
The employment of site-specific administration in colon is a promising technique to improve efficacy and reduce systemic side effects of anticancer...
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Gastroretentive Sustained-Release Tablets Combined with a Solid Self-Micro-Emulsifying Drug Delivery System Adsorbed onto Fujicalin®
Gastroretentive drug delivery systems (GRDDS) get retained in the stomach for a long time, thus facilitating the absorption of drugs in the upper...
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Development and Optimization of Microballoons Assisted Floating Tablets of Baclofen
The objective of the present study was to develop microballoons aided gastro-retentive floating tablets of baclofen, a skeletal muscle relaxant with...
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Minimum Interfacial Bonding Strength for Bilayer Tablets Determined Using a Survival Test
PurposeTo identify the minimum interfacial bonding strength (IBS) required for bilayer tablets to sustain the stresses experienced during...
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Rapidly dissolving bilayer microneedles enabling minimally invasive and efficient protein delivery to the posterior segment of the eye
The discovery of proteins that neutralise vascular endothelial growth factors, such as pegaptanib, ranibizumab and aflibercept, can inhibit the...
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Strategic design and clinical evaluation of a fixed-dose combination tablet comprising valsartan, amlodipine, rosuvastatin and ezetimibe for patients with hypertension and dyslipidemia
PurposeThe objective of this study was to design a fixed-dose combination (FDC) tablet with minimal interaction of valsartan, amlodipine,...
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Exploring the Potential of Hydrophilic Matrix Combined with Insoluble Film Coating: Preparation and Evaluation of Ambroxol Hydrochloride Extended Release Tablets
To explore the potential utility of combination of hydrophilic matrix with membrane-controlled technology, the present study prepared tablets of a...
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Three-Dimensional Printing for Oral Pharmaceutical Dosage Forms
BackgroundThe advent of three-dimensional (3D) printers in the pharmaceutical industry is making a leap forward. 3D printing technology can be...
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Sustained Release Bilayer Tablet of Ibuprofen and Phenylephrine Hydrochloride: Preparation and Pharmacokinetics in Beagle Dogs
Cold is a global common infectious disease accompanied by symptoms such as headache and stuffy nose. Ibuprofen (IBU) and phenylephrine hydrochloride...
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Liposomes as Efficient Drug Delivery Vehicles to Combat Antimicrobial Resistance
Antimicrobial resistance (AMR) poses a growing global health threat, placing a significant economic burden on healthcare systems and jeopardizing...
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Semi-Solid Extrusion (SSE) in Pharmaceuticals
Semi-solid extrusion (SSE) is an extrusion-based 3D printing technique, widely employed in food printing and bioprinting. In pharmaceutics, SSE is...
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Colon-Targeted Layer-by-Layer Self-assembled Film: Pharmacokinetic Analysis of BCS Class I and Class III Model Drugs
The aim of the study was to investigate the pharmacokinetic parameters of 5-fluorouracil (5FU) and moxifloxacin HCl (MF) after oral administration...
