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Effects of benztropine analogs on delay discounting in rats
RationaleMethylphenidate and d -amphetamine, medications used for treatment of attention deficit hyperactivity disorder (ADHD), are used...
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Motor and non-motor symptoms, drugs, and their mode of action in Parkinson’s disease (PD): a review
Parkinson’s disease is second most common neurodegenerative disorder neurological illness that primarily affects patients in their later years of...
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Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth
The endogenous cholinergic system plays a key role in neuronal cells, by suppressing neurite outgrowth and myelination and, in some cancer cells,...
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Discovery and Development of Monoamine Transporter Ligands
Monoamine transporters (MATs) are targets of a wide range of compounds that have been developed as therapeutic treatments for various...
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Safety of Physostigmine for Pediatric Antimuscarinic Poisoning
IntroductionPhysostigmine fell out of widespread use in the 1980s due to safety concerns; however, more recent research has demonstrated that its...
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Cholinergic Functioning, Cognition, and Anticholinergic Medication Burden in Schizophrenia
Acetylcholine (ACh) signaling is critical for central nervous function and is known to be abnormal in schizophrenia (SZ), a chronic neuropsychiatric...
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Trends in Biomarkers of Neurodegenerative Diseases
An agreed-upon action plan is necessary by national health funding and research agencies over the next decade to lower the number of new cases of...
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A systematic review on the use of clozapine in treatment of tardive dyskinesia and tardive dystonia in patients with psychiatric disorders
RationaleThough clozapine is recommended for treatment of tardive dyskinesia (TD) relating to the use of antipsychotic medications, studies...
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Botulinum Toxin Therapy for Autonomic Dysfunction (Excessive Drooling/Sialorrhea and Excessive Sweating (Hyperhidrosis) and for Certain Skin Disorders
Injection of botulinum toxins to the glands reduces the secretion of saliva or sweat by blocking the release of nerve signal transmitter...
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Orientin Modulates Nrf2-ARE, PI3K/Akt, JNK-ERK1/2, and TLR4/NF-kB Pathways to Produce Neuroprotective Benefits in Parkinson's Disease
Parkinson's disease (PD) is characterized by oxidative stress and neuroinflammation as key pathological features. Emerging evidence suggests that...
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Pharmacologic therapies of pain in patients with spinal cord injury: a systematic review
Study designSystematic review.
ObjectivesThis systematic review evaluates all randomized clinical trials (RCTs) conducted on assessing the efficacy...
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Self-reported periodontitis and C-reactive protein in Parkinson’s disease: a cross-sectional study of two American cohorts
Periodontitis triggers systemic repercussions, such as elevated levels of high-sensitive C-reactive protein (hs-CRP). This has never been studied...
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Investigations of the Interaction Mechanism Between Orphenadrine Hydrochloride and Bovine Serum Albumin by Spectroscopic and Voltammetric Techniques
The interaction of orphenadrine hydrochloride (ORD) with the model protein, bovine serum albumin (BSA), was investigated using a variety of...
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Behavioral economic analysis of the effects of N-substituted benztropine analogs on cocaine self-administration in rats
Rationale and objectivesBenztropine (BZT) analogs and other atypical dopamine uptake inhibitors selectively decrease cocaine self-administration at...
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Reverse Takotsubo Cardiomyopathy Precipitated by Chronic Cocaine and Cannabis Use
This case report describes a 31-year-old man with 10 years of cocaine and cannabis dependence who developed reverse Takotsubo cardiomyopathy (rTC), a...
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Analysis of clinical studies on clozapine from 2012-2022
Clozapine has been considered the “gold standard” in the treatment of schizophrenia for many years. Clozapine has a superior effect, particularly in...
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Mycotherapeutics Affecting Dopaminergic Neurotransmission to Exert Neuroprotection
Alternative or integrative medicine is a holistic approach to healthcare that has been used for centuries in many different cultures. Today, there is...
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Gait abnormalities and non-motor symptoms predict abnormal dopaminergic imaging in presumed drug-induced Parkinsonism
Drug-induced parkinsonism (DIP) can be clinically indistinguishable from degenerative parkinsonism, and bedside assessments are needed to...
