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Benzo(a)Pyrene-Induced ROS-Mediated Lung Cancer
Lung cancer is the world’s second-largest cause of death from cancer. Cigarette smoking is identified as one of the single, well-known risk factors...
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Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer
Benzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco...
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Metabolism of benzo[a]pyrene after low-dose subchronic exposure to an industrial mixture of carcinogenic polycyclic aromatic hydrocarbons in rats: a cocktail effect study
Polycyclic aromatic hydrocarbons (PAHs) are interesting environmental pollutants for understanding cocktail effects. High-molecular-weight-PAHs...
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Benzo(a)Pyrene Induced ROS-Mediated Lung Cancer
Lung cancer is the world’s second-largest cause of death from cancer. Cigarette smoking is identified as one of the single, well-known risk factors...
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Benzo(a)Pyrene-Induced Oxidative Stress During Lung Cancer and Treatment with Baicalein
Toxicity of benzo(a)pyrene [B(a)P] is frequently intervened by oxidative metabolism to reactive intermediates that interrelate with macromolecules...
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In Vivo Cancer Microenvironment Responsive Glycan Receptor-Targeted Nanoparticles for Gemcitabine Delivery to Benzo[a]pyrene-Induced Lung Cancer Model
Targeted gemcitabine (GEB) loaded 5-N-acetyl-neuraminic acid (Neu5Ac) assembled chitosan nanoparticles (CA-NPs) were formulated by ionotropic...
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Characterization of two keystone taxa, sulfur-oxidizing, and nitrate-reducing bacteria, by tracking their role transitions in the benzo[a]pyrene degradative microbiome
BackgroundKeystone taxa are drivers of microbiome structure and functioning, which may play critical roles in microbiome-level responses to...
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Ameliorative effects of Bifidobacterium longum peptide-1 on benzo(α)pyrene induced oxidative damages via daf-16 in Caenorhabditis elegans
Oxidative stress is implicated in numerous diseases, with benzo(α)pyrene (BaP) known for causing substantial oxidative damage. Bifidobacterium longum ...
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Predicting the in vivo developmental toxicity of benzo[a]pyrene (BaP) in rats by an in vitro–in silico approach
Developmental toxicity testing is an animal-intensive endpoints in toxicity testing and calls for animal-free alternatives. Previous studies showed...
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Benzo(a)pyrene-Induced Oxidative Stress During Lung Cancer and Treatment with Baicalein
Toxicity of benzo(a)pyrene [B(a)P] is frequently intervened by oxidative metabolism to reactive intermediates that interrelate with macromolecules...
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Competitive and/or cooperative interactions of graphene-family materials and benzo[a]pyrene with pulmonary surfactant: a computational and experimental study
BackgroundAirborne nanoparticles can be inhaled and deposit in human alveoli, where pulmonary surfactant (PS) molecules lining at the alveolar...
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The protective effect of melatonin on benzo(a)pyrene-induced brain injury: role of apoptosis and autophagy pathways
Benzo(a)pyrene (BaP), a toxic polycyclic aromatic hydrocarbon, is spread in different ways as an environmental pollutant. It has been proposed that...
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A Highly Fluorescent Pyrene-Based Sensor for Selective Detection Of Fe3+ Ion in Aqueous Medium: Computational Investigations
In this work, we introduce a highly selective and sensitive fluorescent sensor based on pyrene derivative for Fe(III) ion sensing in DMSO/water...
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Benzo(a)pyrene exposure induced neuronal loss, plaque deposition, and cognitive decline in APP/PS1 mice
BackgroundExposure to benzo(a)pyrene (BaP) was associated with cognitive impairments and some Alzheimer’s disease (AD)-like pathological changes....
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Ruthenium biochanin-A complex ameliorates lung carcinoma through the downregulation of the TGF-β/PPARγ/PI3K/TNF-α pathway in association with caspase-3-mediated apoptosis
Lung cancer is the most often reported cancer with a terrible prognosis worldwide. Flavonoid metal complexes have exhibited potential...
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Benzo[a]pyrene and Caenorhabditis elegans: defining the genotoxic potential in an organism lacking the classical CYP1A1 pathway
Benzo[ a ]pyrene (BaP) is bioactivated in most organisms by the cytochrome P450 (CYP) enzymes, mainly CYP1A1, ultimately resulting in the reactive...
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Impact of Environmental Stress on Gene Modification, Cancer, and Chemoresistance
A deteriorating human–environment relationship has induced environmental stress, leading to genome instability. The factors responsible for the...
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Derivation of metabolic point of departure using high-throughput in vitro metabolomics: investigating the importance of sampling time points on benchmark concentration values in the HepaRG cell line
Amongst omics technologies, metabolomics should have particular value in regulatory toxicology as the measurement of the molecular phenotype is the...
