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Basiliximab Does Not Impair Airway Mucociliary Clearance of Rats
Previous studies have shown that immunosuppressive drugs impair the airway mucociliary clearance of rats. However, considering the high specificity...
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Network proximity analysis as a theoretical model for identifying potential novel therapies in primary sclerosing cholangitis
Primary Sclerosing Cholangitis (PSC) is a progressive cholestatic liver disease with no licensed therapies. Previous Genome Wide Association Studies...
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Antibody Therapies in Autoimmune Inflammatory Myopathies: Promising Treatment Options
Inflammatory myopathies, including polymyositis (PM), dermatomyositis (DM), inclusion body myositis (IBM), necrotizing myopathy (NM), antisynthetase...
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Investigation of interleukin-2-mediated changes in blood pressure, fetal growth restriction, and innate immune activation in normal pregnant rats and in a preclinical rat model of preeclampsia
Two important clinical features of preeclampsia (PE) are hypertension and fetal growth restriction. The reduced uterine perfusion pressure (RUPP)...
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Monoclonal Antibodies in Solid Organ Transplantation
In an attempt to target solid organ transplant immunosuppression, monoclonal antibodies directed against key steps in specific immunologic pathways...
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Exploratory associations of tacrolimus exposure and clinical outcomes after lung transplantation: A retrospective, single center experience
PurposeThis study aimed to investigate the potential impact of tacrolimus (TAC) exposure on clinical outcomes after lung transplantation.
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Risk factors of early bacterial infection and analysis of bacterial composition, distribution and drug susceptibility after cadaveric liver transplantation
BackgroundThis study provided a theoretical basis for the clinical diagnosis and treatment of bacterial infection after liver transplantation through...
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Induction Therapy and Therapeutic Antibodies
Prevention of allograft rejection is one of the crucial goals in solid organ transplantation to ensure durability of the graft and is chiefly...
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A case of successful contribution of therapeutic drug monitoring of valganciclovir as the prophylaxis against cytomegalovirus infection in a lung transplant recipient
BackgroundGanciclovir and its prodrug, valganciclovir, are first-line agents for cytomegalovirus infection prophylaxis after lung transplantation....
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Novel Immunosuppression in Solid Organ Transplantation
Solid organ transplantation and survival has improved tremendously in the last few decades, much of the success has been attributed to the...
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The pharmacogenetics of tacrolimus in renal transplant patients: association with tremors, new-onset diabetes and other clinical events
Our study is the first study to investigate the effect of SNPs in CYP3A5 , CYP3A4 , ABCB1 and POR genes on the incidence of tremors, nephrotoxicity,...
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Development and Application of a Physiologically-Based Pharmacokinetic Model to Predict the Pharmacokinetics of Therapeutic Proteins from Full-term Neonates to Adolescents
Physiologically-based pharmacokinetic (PBPK) modelling provides an integrated framework to predict the disposition of small molecule drugs in...
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Association between time in therapeutic range of tacrolimus blood concentration and acute rejection within the first three months after lung transplantation
BackgroundTacrolimus is a key drug in immunosuppressive therapy following lung transplantation. The blood tacrolimus levels are likely to fluctuate...
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Composite CYP3A (CYP3A4 and CYP3A5) phenotypes and influence on tacrolimus dose adjusted concentrations in adult heart transplant recipients
CYP3A5 genetic variants are associated with tacrolimus metabolism. Controversy remains on whether CYP3A4 increased [* 1B (rs2740574), * 1 G ...
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Long-term survival from progressive multifocal leukoencephalopathy in living-donor liver transplant recipient with preformed donor-specific antibody
Intensive immunosuppression has enabled liver transplantation even in recipients with preformed donor-specific antibodies (DSA), an independent risk...
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Application of metagenomic next-generation sequencing in the diagnosis and treatment guidance of Pneumocystis jirovecii pneumonia in renal transplant recipients
Pneumocystis jirovecii pneumonia (PJP) is difficult to be diagnosed, so this study explored if PJP could be diagnosed by metagenomic next-generation...
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Adverse Effects of Immunosuppression: Infections
Immunosuppressive therapies are currently indicated for a wide range of diseases. As new agents emerge and indications evolve the landscape grows...
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Decreased frequency of Th22 cells and IL-22 cytokine in kidney transplant patients with active cytomegalovirus infection
BackgroundThe immunity of CD4 + T cell subsets against human cytomegalovirus (HCMV) is considerable due to their essential role in controlling the...
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Monoclonal Antibodies: From Structure to Therapeutic Application
The exciting field of therapeutic monoclonal antibodies (mAbs) had its origins when Köhler and Milstein presented their murine hybridoma technology...