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Basal Transcriptional Machinery
In this chapter, we will discuss the impact of TSS regions, which are also known as core promoters. This is a prerequisite for understanding how...
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Core promoter mutation contributes to abnormal gene expression in bladder cancer
BackgroundBladder cancer is one of the most mortal cancers. Bladder cancer has distinct gene expression signature, highlighting altered gene...
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Aberrant promoter methylation contributes to LRIG1 silencing in basal/triple-negative breast cancer
BackgroundLRIG1, the founding member of the LRIG (leucine-rich repeat and immunoglobulin-like domain) family of transmembrane proteins, is a negative...
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Interaction between MED12 and ΔNp63 activates basal identity in pancreatic ductal adenocarcinoma
The presence of basal lineage characteristics signifies hyperaggressive human adenocarcinomas of the breast, bladder and pancreas. However, the...
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Enhancer–promoter specificity in gene transcription: molecular mechanisms and disease associations
Although often located at a distance from their target gene promoters, enhancers are the primary genomic determinants of temporal and spatial...
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ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity
PurposeTumor heterogeneity complicates patient treatment and can be due to transitioning of cancer cells across phenotypic cell states. This process...
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Lineage plasticity enables low-ER luminal tumors to evolve and gain basal-like traits
Stratifying breast cancer into specific molecular or histologic subtypes aids in therapeutic decision-making and predicting outcomes; however, these...
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A type 1 immunity-restricted promoter of the IL−33 receptor gene directs antiviral T-cell responses
The pleiotropic alarmin interleukin-33 (IL-33) drives type 1, type 2 and regulatory T-cell responses via its receptor ST2. Subset-specific...
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Enhancer–promoter contact formation requires RNAPII and antagonizes loop extrusion
Homotypic chromatin interactions and loop extrusion are thought to be the two main drivers of mammalian chromosome folding. Here we tested the role...
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Engineered compact pan-neuronal promoter from Alphaherpesvirus LAP2 enhances target gene expression in the mouse brain and reduces tropism in the liver
Small promoters capable of driving potent neuron-restricted gene expression are required to support successful brain circuitry and clinical gene...
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AKT1 induces Nanog promoter in a SUMOylation-dependent manner in different pluripotent contexts
AKT/PKB is a kinase crucial for pluripotency maintenance in pluripotent stem cells. Multiple post-translational modifications modulate its activity....
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The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis
Breast cancer is the most prevalent cancer worldwide, and metastasis is the leading cause of death in cancer patients. Human monocyte chemoattractant...
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Functional analysis of a viral promoter from a strawberry vein banding virus isolate from China
BackgroundPromoters are important factors affecting gene expression in cells. The driven activities of viral promoters were generally assessed to...
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Basal Transcriptional Machinery
The TSS region, which is also called core promoter, is a pre-requisite for the understanding how transcription by Pol II is controlled. Pol II is the...
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Meta-analysis to Unravel Core Transcriptomic Responses in Penaeus vannamei Exposed to Biotic and Abiotic Stresses
Shrimp farming, a dominant economic activity in coastal areas, is affected by different abiotic and biotic stress factors. These stressors, under...
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Cloning and Functional Analysis of Rat Tweety-Homolog 1 Gene Promoter
Tweety-homolog 1 protein ( Ttyh1 ) is abundantly expressed in neurons in the healthy brain, and its expression is induced under pathological...
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Loss of BRCA1 expression and morphological features associated with BRCA1 promoter methylation status in triple-negative breast cancer
Aberrant DNA methylation in the BRCA1 promoter region causes epigenetic silencing of BRCA1 gene expression, which is critical for breast cancer...
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Identification of ZBTB18 as a novel colorectal tumor suppressor gene through genome-wide promoter hypermethylation analysis
BackgroundCancer initiation and progression are driven by genetic and epigenetic changes. Although genome/exome sequencing has significantly...
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Molecular dynamics simulation reveals DNA-specific recognition mechanism via c-Myb in pseudo-palindromic consensus of mim-1 promoter
This study aims to gain insight into the DNA-specific recognition mechanism of c-Myb transcription factor during the regulation of cell early...
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GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter
GABAergic interneurons play a critical role in tuning neural networks in the central nervous system, and their defects are associated with...
