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Passive immunotherapy for Alzheimer’s disease: challenges & future directions
Passive immunotherapy with specific antibodies targeting Amyloid β (Aβ) peptide or tubulin-associated unit (tau) protein has emerged as a promising...
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Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer’s disease immunotherapeutics
Despite ongoing debate, the amyloid β-protein (Aβ) remains the prime therapeutic target for the treatment of Alzheimer’s disease (AD). However,...
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ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer’s disease with a bispecific, brain-penetrating fusion protein
BackgroundHijacking the transferrin receptor (TfR) is an effective strategy to transport amyloid-beta (Aβ) immuno-positron emission tomography...
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Perspectives of Stem Cell Therapy: A Promising Therapeutic for Cancer Model and Alzheimer’s Disease
The most promising therapeutic option is cancer stem cells (CSCs). CSCs, leaders of a cancer hierarchy, possess stem cell-like traits such as...
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Role of Immunotherapy in Ameliorating Proteopathic Dementia
Dementia is a syndrome that marks a significant cognitive decline with an estimated 50 million populations being affected by this globally and...
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Pharmacotherapy of Alzheimer’s disease: an overview of systematic reviews
BackgroundAlzheimer’s disease (AD) is a neurodegenerative disease and the most common cause of dementia. In this umbrella systematic review (SR), we...
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Perspectives of Stem Cell Therapy: A Promising Therapeutic for Cancer Model and Alzheimer’s Disease
The most promising therapeutic option is cancer stem cells (CSCs). CSCs, leaders of a cancer hierarchy, possess stem cell-like traits such as...
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Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
BackgroundAmyloid-related imaging abnormalities (ARIA) have been identified as the most common and serious adverse events resulting from pathological...
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The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics
Many drugs that target amyloid-β (Aβ) in Alzheimer disease (AD) have failed to demonstrate clinical efficacy. However, four anti-Aβ antibodies have...
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Lecanemab, Aducanumab, and Gantenerumab — Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer’s Disease
Immunotherapy against amyloid-beta (Aβ) is a promising option for the treatment of Alzheimer’s disease (AD). Aβ exists as various species, including...
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Anti-Amyloid Immunotherapies for Alzheimer’s Disease: A 2023 Clinical Update
The amyloid cascade hypothesis is a useful framework for therapeutic development in Alzheimer’s disease (AD). Amyloid b 1-42 (Aβ) has been the main...
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The Current Landscape of Prevention Trials in Dementia
As the prevalence of dementia and Alzheimer’s disease (AD) increases worldwide, it is imperative to reflect on the major clinical trials in the...
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Immunotherapy: An Approach to Treat Alzheimer’s Disease and Autism Spectrum Disorder
Since the late 1980s, Alzheimer’s disease (AD) and autism spectrum disorder (ASD) had spread rapidly, and still, it persists in growing numbers....
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Biomarkers and Target-Specific Small-Molecule Drugs in Alzheimer’s Diagnostic and Therapeutic Research: From Amyloidosis to Tauopathy
Alzheimer’s disease (AD) is the most common type of human dementia and is responsible for over 60% of diagnosed dementia cases worldwide. Abnormal...
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Ignorance or Conspiracy? Or Just an Amyloid Firewall that Blocks Alternative Ideas?
From an epistemological standpoint, the ongoing persistence of the amyloid cascade hypothesis is a prime example of a typical course of persisting...
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The Late Stage of Abnormal Aging: Dementia
With the growth of the aging population, more age-related diseases endanger the health of the elderly, and therefore more research attention has been...
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Treatment Strategies for Alzheimer’s Disease-Associated Epilepsy: Past, Present, and Future Approaches
Numerous studies have established a probable bidirectional relationship between Alzheimer’s disease (AD) and epilepsy due to shared...
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Deciphering the Molecular and Genetic Basis of Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive age-related neurodegenerative disease in humans characterized by a decline in cognitive and personal daily...