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RNA sequencing reveals differential long noncoding RNA expression profiles in bacterial and viral meningitis in children
BackgroundWe aimed to investigate the involvement of long non-coding RNA (lncRNA) in bacterial and viral meningitis in children.
Methods ...
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Diagnostic value of cerebrospinal fluid Neutrophil Gelatinase-Associated Lipocalin for differentiation of bacterial meningitis from tuberculous meningitis or cryptococcal meningitis: a prospective cohort study
BackgroundThe early differential diagnosis between bacterial meningitis (BM) and tuberculous meningitis (TBM) or cryptococcal meningitis (CM) remains...
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Persistent headaches one year after bacterial meningitis: prevalence, determinants and impact on quality of life
BackgroundLittle is known on headaches long-term persistence after bacterial meningitis and on their impact on patients’ quality of life.
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Epidemiology and antimicrobial resistance patterns of bacterial meningitis among hospitalized patients at a tertiary care hospital in Saudi Arabia: a six-year retrospective study
IntroductionBacterial meningitis poses significant medical challenges due to its acute inflammatory nature and potential for severe neurological...
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Determine the factors affecting the time to recovery of children with bacterial meningitis at Jigjiga university referral hospital in the Somali Regional State of Ethiopia: using the parametric shared frailty and AFT models
BackgroundNeisseria meningitides, Streptococcus pneumonia, and hemophilic influenza type B are frequently linked to bacterial meningitis (BM) in...
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Diagnosis of pathogens causing bacterial meningitis using Nanopore sequencing in a resource-limited setting
AimThe aim of the present study is to compare the performance of 16S rRNA Nanopore sequencing and conventional culture in detecting infectious...
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Molecular and Cellular Mechanism of Pathogen Invasion into the Central Nervous System: Meningitis
Meningitis, a deadly ailment that affects the central nervous system (CNS), involves the inflammation of the brain and spinal cord’s protective...
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NLRP3 Activation Contributes to Memory Impairment in an Experimental Model of Pneumococcal Meningitis
Bacterial meningitis is considered a life-threatening condition with high mortality rates. In response to the infection, signaling cascades,...
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Integrating DNA/RNA microbe detection and host response for accurate diagnosis, treatment and prognosis of childhood infectious meningitis and encephalitis
BackgroundInfectious meningitis/encephalitis (IM) is a severe neurological disease that can be caused by bacterial, viral, and fungal pathogens. IM...
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Treatment outcome and associated factors of bacterial meningitis at pediatric wards of southwestern Ethiopian hospital: a prospective observational study
BackgroundMeningitis is a common infectious cause of morbidity and mortality in pediatric age-groups. Acute bacterial meningitis is considered a...
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The role of plasminogen activator inhibitor-2 in pneumococcal meningitis
Pneumococcal meningitis is associated with dysregulation of the coagulation cascade. Previously, we detected upregulation of cerebral plasminogen...
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Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis
Interactions between the immune and central nervous systems strongly influence brain health. Although the blood–brain barrier restricts this...
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Group A Streptococcal meningitis in children: a short case series and systematic review
BackgroundGroup A streptococcal(GAS) meningitis is a severe disease with a high case fatality rate. In the era of increasing GAS meningitis, our...
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A multicenter evaluation of the QIAstat-Dx meningitis-encephalitis syndromic test kit as compared to the conventional diagnostic microbiology workflow
PurposeRapid diagnosis and treatment of infectious meningitis and encephalitis (ME) is critical to minimize morbidity and mortality. Recently, Qiagen...
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Pericytes are protective in experimental pneumococcal meningitis through regulating leukocyte infiltration and blood–brain barrier function
BackgroundBrain pericytes participate in the regulation of cerebral blood flow and the maintenance of blood–brain barrier integrity. Because of their...
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Brain Immune Cell Infiltration and Serum Metabolomic Characteristics Reveal that Lauric Acid Promotes Immune Cell Infiltration in Brain and Streptococcus suis Meningitis in Mice
Although naturally Streptococcus suis serotype 2 (SS2) causes meningitis resulting in death or sequela of neurological symptoms in pigs and humans,...
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Deciphering the TLR transcriptome and downstream signaling pathway in cerebrospinal fluid in pediatric meningitis
Objective/designPediatric meningitis is characterized by a colossal inflammatory response to the pathogen in the central nervous system (CNS). This...
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Varicella-zoster virus meningitis coincident with bacteremia caused by liver abscess: a case report
Varicella-zoster virus (VZV) meningitis is sometimes associated with herpes zoster, which is also associated with various other infectious diseases....
