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BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancer
BackgroundTriple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer subtype often treated with radiotherapy (RT). Due to its...
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BUB1, BUB1B, CCNA2, and CDCA8, along with miR-524-5p, as clinically relevant biomarkers for the diagnosis and treatment of endometrial carcinoma
BackgroundEndometrial carcinoma (EC) is a malignant tumor of the female reproductive tract that has been associated with increased morbidity and...
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BUB1 drives the occurrence and development of bladder cancer by mediating the STAT3 signaling pathway
BackgroundThe incidence of bladder urothelial carcinoma (UC), a common malignancy of the urinary tract, is approximately three times higher in men...
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Bioinformatic identification and experiment validation reveal 6 hub genes, promising diagnostic and therapeutic targets for Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disease that can cause dementia. We aim to screen out the hub genes involved in...
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Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism
BackgroundAcquisition of the chemoresistance to docetaxel (DTX), a microtubule-targeting agent, has been a huge obstacle in treatment for metastatic...
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Unraveling malignant phenotype of peritumoral tissue: transcriptomic insights into early-stage breast cancer
BackgroundEarly-stage invasive ductal carcinoma displays high survival rates due to early detection and treatments. However, there is still a chance...
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Exploration of subtype-specific perturbations in breast cancer
Breast cancer remains a leading cause of mortality among women, characterized by its complex and diverse nature, comprising various molecular...
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NudCD1 as a prognostic marker in colorectal cancer and its role in the upregulation of cellular spindle assembly checkpoint genes and LIS1 pathways
ObjectiveTo investigate the role of NudCD1 in spindle assembly checkpoint regulation and in the prognosis of colorectal cancer.
Methods ...
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The biological function and clinical significance of STIL in osteosarcoma
BackgroundSCL/TAL1 interrupting locus (STIL) is associated with the progression of several tumors; however, the biological role of STIL in...
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circ_0061265 competitively binds to microRNA-885-3p to promote the development of gastric cancer by upregulating AURKA expression
BackgroundCircular RNAs (circRNAs) represent a class of newly identified transcripts that act as competing endogenous RNAs (ceRNAs) to modulate gene...
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Evaluation of clinical value and potential mechanism of MTFR2 in lung adenocarcinoma via bioinformatics
BackgroundMitochondrial fission regulator 2 (MTFR2) was involved in the progression and development of various cancers. However, the relationship...
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Construction and investigation of a combined hypoxia and stemness index lncRNA-associated ceRNA regulatory network in lung adenocarcinoma
Hypoxia and stemness are important factors in tumor progression. We aimed to explore the ncRNA classifier associated with hypoxia and stemness in...
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Prodromal Parkinson disease signs are predicted by a whole-blood inflammatory transcriptional signature in young Pink1−/− rats
BackgroundParkinson disease (PD) is the fastest growing neurodegenerative disease. The molecular pathology of PD in the prodromal phase is poorly...
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Gene interaction network analysis in multiple myeloma detects complex immune dysregulation associated with shorter survival
The plasma cell cancer multiple myeloma (MM) varies significantly in genomic characteristics, response to therapy, and long-term prognosis. To...
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Transcriptomics-based liquid biopsy panel for early non-invasive identification of peritoneal recurrence and micrometastasis in locally advanced gastric cancer
BackgroundThis study aimed to develop a novel six-gene expression biomarker panel to enhance the early detection and risk stratification of...
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Dynamics of the Spindle Assembly Checkpoint
The spindle assembly checkpoint (SAC) normally acts to prevent cells that have not fully completed separation of their replicated chromosomes from...
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Upregulation of TTK expression is associated with poor prognosis and immune infiltration in endometrial cancer patients
BackgroundThreonine and tyrosine kinase (TTK) is associated with invasion and metastasis in various tumors. However, the prognostic importance of TTK...
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Epithelial–Mesenchymal Transition and Cancer Stem Cells
Epithelial–mesenchymal transition (EMT), a cellular phenotypic change from epithelial to mesenchymal-like features, is related to the resistance and...
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A co-formulation of interferons alpha2b and gamma distinctively targets cell cycle in the glioblastoma-derived cell line U-87MG
BackgroundHeberFERON is a co-formulation of α2b and γ interferons, based on their synergism, which has shown its clinical superiority over individual...
