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Showing 1-8 of 8 results

  1. Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats

    Background

    Microglia-mediated neuroinflammation plays a crucial role in the pathogenesis of hypoxic-ischemic (HI)-induced brain injury. Activation of...

    Shufeng Yu, Desislava Met Doycheva, ... John H. Zhang in Journal of Neuroinflammation
    Article Open access 19 January 2021

  2. Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats

    Neuroinflammation plays a vital role in early brain injury (EBI) following subarachnoid hemorrhage (SAH). The hypothesis of this study was that...

    Weilin Xu, Jun Mo, ... John H. Zhang in Neurotherapeutics
    Article 29 August 2019

  3. Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s disease

    Background

    Epidemiological studies suggest a link between the melanoma-related pigmentation gene melanocortin 1 receptor ( MC1R ) and risk of...

    Waijiao Cai, Pranay Srivastava, ... **qun Chen in Molecular Neurodegeneration
    Article Open access 23 February 2022

  4. A systematic review of immune-based interventions for perinatal neuroprotection: closing the gap between animal studies and human trials

    Background

    Perinatal infection/inflammation is associated with a high risk for neurological injury and neurodevelopmental impairment after birth....

    Sharmony B. Kelly, Nhi T. Tran, ... Robert Galinsky in Journal of Neuroinflammation
    Article Open access 20 October 2023

  5. Sirtuins as Potential Targets for Neuroprotection: Mechanisms of Early Brain Injury Induced by Subarachnoid Hemorrhage

    Subarachnoid hemorrhage (SAH) is a prevalent cerebrovascular disease with significant global mortality and morbidity rates. Despite advancements in...

    Kunqian Lei, Rui Wu, ... Lei Gong in Translational Stroke Research
    Article Open access 02 October 2023

  6. Inflammation, Anti-inflammatory Interventions, and Post-stroke Cognitive Impairment: a Systematic Review and Meta-analysis of Human and Animal Studies

    The pathophysiology and treatment of post-stroke cognitive impairment (PSCI) are not clear. Stroke triggers an inflammatory response, which might...

    Reinier W. P. Tack, Claudia Amboni, ... Elly M. Hol in Translational Stroke Research
    Article Open access 28 November 2023

  7. Melanocortin Control of Cell Trafficking in Vascular Inflammation

    Over 20 years of research based upon application of experimental models of inflammation and tissue injury have revealed exquisite...
    Hetal B. Patel, Giovanna Leoni, ... Mauro Perretti in Melanocortins: Multiple Actions and Therapeutic Potential
    Chapter 2010

  8. Melanocortins

    Stephen J. Getting in Encyclopedia of Molecular Pharmacology
    Reference work entry 2008
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