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Identification of senescent, TREM2-expressing microglia in aging and Alzheimer’s disease model mouse brain
Alzheimer’s disease (AD) and dementia in general are age-related diseases with multiple contributing factors, including brain inflammation....
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Inhibitory receptor CD47 binding to plasma TSP1 suppresses NK-cell IFN-γ production via activating the JAK/STAT3 pathway during HIV infection
BackgroundNatural killer (NK) cells play an important first-line role against tumour and viral infections and are regulated by inhibitory receptor...
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Bcl-xL DNAzymes promote radiosensitivity and chemosensitivity in colorectal cancer cells via enhancing apoptosis
BackgroundRNA-cleaving deoxyribozymes (DNAzymes) are catalytic deoxyribonucleic acid molecules that have become a promising new class of gene...
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A novel Mcl-1 inhibitor synergizes with venetoclax to induce apoptosis in cancer cells
BackgroundEvading apoptosis by overexpression of anti-apoptotic Bcl-2 family proteins is a hallmark of cancer cells and the Bcl-2 selective inhibitor...
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CD8+ CD226high T cells in liver metastases dictate the prognosis of colorectal cancer patients treated with chemotherapy and radical surgery
CD226 has been reported to participate in the rescue of CD8 + T cell dysfunction. In this study, we aimed to assess the prognostic value of CD226 in...
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EIF4A inhibition targets bioenergetic homeostasis in AML MOLM-14 cells in vitro and in vivo and synergizes with cytarabine and venetoclax
BackgroundAcute myeloid leukemia (AML) is an aggressive hematological cancer resulting from uncontrolled proliferation of differentiation-blocked...
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An anti-LpqH human monoclonal antibody from an asymptomatic individual mediates protection against Mycobacterium tuberculosis
Tuberculosis (TB) is an airborne disease caused by Mycobacterium tuberculosis (Mtb). Whilst a functional role for humoral immunity in Mtb protection...
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Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice
Silver nanoparticles (AgNP) are among the most widely commercialized nanomaterials globally, with applications in medicine and the food industry....
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The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial
BackgroundAging is associated with progressive declines in immune responses leading to increased risk of severe infection and diminished vaccination...
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Dynamics and durability of HIV-1 neutralization are determined by viral replication
Human immunodeficiency virus type 1 (HIV-1)-neutralizing antibodies (nAbs) that prevent infection are the main goal of HIV vaccine discovery. But as...
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Eomes expression identifies the early bone marrow precursor to classical NK cells
Natural killer (NK) cells traffic through the blood and mount cytolytic and interferon-γ (IFNγ)-focused responses to intracellular pathogens and...
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Exploratory development of PCR-fluorescent probes in rapid detection of mutations associated with extensively drug-resistant tuberculosis
This study aims to evaluate the clinical value of PCR-fluorescent probes for detecting the mutation gene associated with extensively drug-resistant...
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Short-chain fatty acid-mediated epigenetic modulation of inflammatory T cells in vitro
Short-chain fatty acids (SCFAs) are major metabolic products of indigestible polysaccharides in the gut and mediate the function of immune cells to...
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Mendelian randomization analyses in ocular disease: a powerful approach to causal inference with human genetic data
Ophthalmic epidemiology is concerned with the prevalence, distribution and other factors relating to human eye disease. While observational studies...
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Targeting bromodomain-containing proteins: research advances of drug discovery
Bromodomain (BD) is an evolutionarily conserved protein module found in 46 different BD-containing proteins (BCPs). BD acts as a specific reader for...
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Characterization of KIR+CD8+ Regulatory T Cells in Humans by scRNA- and TCR-seq
Previous studies have demonstrated the regulatory functions of Ly49+CD8+ T cells toward self-reactive CD4+ T cells in mice. Recently, we found...
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About 4-Day Rhythm of Proliferative Activity of L-929 Cells in Culture Correlates with the Intensity of Secondary Cosmic Radiation Fluctuations
The dynamics of proliferative activity of the L-929 cell culture of mouse fibroblast-like cells in the phase of logarithmic growth was compared with...
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B cell treatment promotes a neuroprotective microenvironment after traumatic brain injury through reciprocal immunomodulation with infiltrating peripheral myeloid cells
Traumatic brain injury (TBI) remains a major cause of death and severe disability worldwide. We found previously that treatment with exogenous naïve...
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N6-Methyladenosine (m6A) Methylation Is Associated with the Immune Microenvironments in Acute Intracerebral Hemorrhage (ICH)
Researchers have recently found that N 6 -methyladenosine (m 6 A) is a type of internal posttranscriptional modification that is essential in mammalian...
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Discovery of novel acridine-chalcone hybrids with potent DNA binding and antiproliferative activity against MDA-MB-231 and MCF-7 cells
Two series of novel chalcone derivatives containing acridin-9-yl or acridin-4-yl moiety have been synthesized, structure elucidated and further...
