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1. BCG: Past, Present and Future Direction

   Bacillus Calmette-Guérin (BCG) is a live-attenuated vaccine developed over 100 years ago and remains the only vaccine ever licensed in the fight...

   Hazel Morrison, Helen McShane in Vaccines for Neglected Pathogens: Strategies, Achievements and Challenges

   Chapter Open access 2023
   

2. Bacillus Calmette-Guérin (BCG)-Induced Protection in Brain Disorders

   The Bacille Calmette-Guerin (BCG) vaccine is one of the most widely used vaccines in the world for the prevention of tuberculosis. Its immunological...

   Khiany Mathias, Richard Simon Machado, ... Fabricia Petronilho in Inflammation

   Article 26 April 2024
   

3. The influence of neonatal BCG vaccination on in vitro cytokine responses to Plasmodium falciparum

   Background

   Bacillus Calmette–Guérin (BCG) vaccination has off-target protective effects against infections unrelated to tuberculosis. Among these,...

   NL Messina, M Wang, ... N Curtis in BMC Immunology

   Article Open access 30 April 2024
   

4. A protective, single-visit TB vaccination regimen by co-administration of a subunit vaccine with BCG

   The only licensed tuberculosis (TB) vaccine, Bacillus Calmette Guerin (BCG), fails to reliably protect adolescents and adults from pulmonary TB,...

   Karin Dijkman, Thomas Lindenstrøm, ... Rasmus Mortensen in npj Vaccines

   Article Open access 09 May 2023
   

5. BCG-induced trained immunity: history, mechanisms and potential applications

   The Bacillus Calmette-Guérin (BCG) vaccine was discovered a century ago and has since been clinically applicable. BCG can not only be used for the...

   **g**g Chen, Li Gao, ... Fukai Bao in Journal of Translational Medicine

   Article Open access 10 February 2023
   

6. 1D Convolutional Neural Network Impact on Heart Rate Metrics for ECG and BCG Signals

   Purpose

   The presence of motion artifacts (MA) in cardiac signals negatively impacts the reliability of higher-level information such as the Heart Rate...

   Juan Pablo Moreno, Miguel A. Sepúlveda, Esteban J. Pino in Journal of Medical and Biological Engineering

   Article 05 June 2024
   

7. BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance

   Bacille Calmette–Guérin (BCG) vaccination can confer nonspecific protection against heterologous pathogens. However, the underlying mechanisms remain...

   Audrey Lee, Katharine Floyd, ... Bali Pulendran in Nature Immunology

   Article 30 November 2023
   

8. BCG immunization induces CX3CR1^hi effector memory T cells to provide cross-protection via IFN-γ-mediated trained immunity

   After a century of using the Bacillus Calmette–Guérin (BCG) vaccine, our understanding of its ability to provide protection against homologous ( Mycoba...

   Kim A. Tran, Erwan Pernet, ... Maziar Divangahi in Nature Immunology

   Article 15 January 2024
   

9. Activation dynamics of antigen presenting cells in vivo against Mycobacterium bovis BCG in different immunized route

   Background

   Control of Tuberculosis (TB) infection is mainly the result of productive teamwork between T-cell populations and antigen presenting cells...

   Zhengzhong Xu, **n Li, ... **n-an Jiao in BMC Immunology

   Article Open access 27 November 2023
   

10. BCG-booster vaccination with HSP90-ESAT-6-HspX-RipA multivalent subunit vaccine confers durable protection against hypervirulent Mtb in mice

    The quest for effective and enhanced multiantigenic tuberculosis (TB) subunit vaccine necessitates the induction of a protective pathogen-specific...

    Kee Woong Kwon, Han-Gyu Choi, ... Sung Jae Shin in npj Vaccines

    Article Open access 08 March 2024
    

11. The Role of Fermentation in BCG Manufacture: Challenges and Ways Forward

    The BCG vaccine has been in existence for a century and has been instrumental in the control of tuberculosis. The method for producing the vaccine...

    Kenneth Barry Walker, Joanna Bacon in Vaccines for Neglected Pathogens: Strategies, Achievements and Challenges

    Chapter Open access 2023
    

12. Clinical and Genetic Characteristics of BCG Disease in Chinese Children: a Retrospective Study

    Purpose

    Summarize the characteristics of a large cohort of BCG disease and compare differences in clinical characteristics and outcomes among...

    Yuyuan Zeng, Wen**g Ying, ... **qiao Sun in Journal of Clinical Immunology

    Article 20 January 2023
    

13. Oncolytic adenoviral therapy plus pembrolizumab in BCG-unresponsive non-muscle-invasive bladder cancer: the phase 2 CORE-001 trial

    Cretostimogene grenadenorepvec is a serotype-5 oncolytic adenovirus designed to selectively replicate in cancer cells with retinoblastoma pathway...

    Roger Li, Paras H. Shah, ... Gary D. Steinberg in Nature Medicine

    Article 06 June 2024
    

14. Reversing BCG-mediated autophagy inhibition and mycobacterial survival to improve vaccine efficacy

    Background

    Autophagy is an important mechanism for promoting Mycobacterium clearance from macrophages. Pathogenic and non-pathogenic mycobacterium...

    Maria Gonzalez-Orozco, Emily J. Strong, ... Sunhee Lee in BMC Immunology

    Article Open access 14 September 2022
    

15. BCG Immunotherapy: Old Tool and New Concepts

    Over half a century after the first use of Bacillus Calmette-Guérin (BCG) on bladder cancer treatment by Morales et al., BCG is still the standard of...

    Mehrsa Jalalizadeh, Luciana S. B. Dal Col, ... Leonardo Oliveira Reis in Handbook of Cancer and Immunology

    Living reference work entry 2022
    

16. Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis

    Aside from centrally induced trained immunity in the bone marrow (BM) and peripheral blood by parenteral vaccination or infection, evidence indicates...

    Mangalakumari Jeyanathan, Maryam Vaseghi-Shanjani, ... Zhou **ng in Nature Immunology

    Article Open access 01 December 2022
    

17. A secreted form of chorismate mutase (Rv1885c) in Mycobacterium bovis BCG contributes to pathogenesis by inhibiting mitochondria-mediated apoptotic cell death of macrophages

    Background

    Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), and its pathogenicity is associated with its ability to evade the...

    Mi-Hyun Lee, Hye Lin Kim, ... Bum-Joon Kim in Journal of Biomedical Science

    Article Open access 18 December 2023
    

18. Inborn Errors of Immunity in Patients with Adverse Events Following BCG Vaccination in Brazil

    Objective

    The  Bacille Calmette-Guérin (BCG) vaccine is routinely applied in Brazil. Adverse events (AE) may occur in patients with inborn or acquired...

    Paula T. Lyra, Edvaldo Souza, ... João Bosco Oliveira in Journal of Clinical Immunology

    Article 30 July 2022
    

19. BCG-mediated viral protection goes biphasic

    Maria Rescigno in Nature Immunology

    Article 02 January 2024
    

20. BCG-induced trained immunity enhances acellular pertussis vaccination responses in an explorative randomized clinical trial

    Acellular pertussis (aP) booster vaccines are central to pertussis immunization programs, although their effectiveness varies. The Bacille...

    Joshua Gillard, Bastiaan A. Blok, ... Dimitri A. Diavatopoulos in npj Vaccines

    Article Open access 17 February 2022