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B Cells and Antibody Production in Cancer
B cells and their products play a key role in the development and progression of cancers, with pro- and antitumoral functions in the tumor...
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Release of Antibodies and Cytokines from B Cells
Autoreactive B cells play a critical role in rheumatoid arthritis (RA). These cells differentiate into long-living memory B cells and...
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Memory B cells
Recent advances in studies of immune memory in mice and humans have reinforced the concept that memory B cells play a critical role in protection...
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PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells
The differentiation of naive and memory B cells into antibody-secreting cells (ASCs) is a key feature of adaptive immunity. The requirement for...
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Obesity accelerates age defects in B cells, and weight loss improves B cell function
BackgroundWe have previously shown that obesity accelerates age-associated defects in B cell function and antibody production leading to decreased...
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Regulatory B Cells Methods and Protocols
This second edition provides new and updated chapters useful for the study of Regulatory B cells. Organized in four sections,...
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PI3K Isoforms in B Cells
Phosphatidylinositol-3-kinases (PI3K) control many aspects of cellular activation and differentiation and play an important role in B cells biology....
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Thioredoxin is a metabolic rheostat controlling regulatory B cells
Metabolic programming is important for B cell fate, but the bioenergetic requirement for regulatory B (B reg ) cell differentiation and function is...
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Tracking Circulating HLA-Specific IgG-Producing Memory B Cells with the B-Cell ImmunoSpot Assay
Donor-specific antibodies (DSA) against human leukocyte antigen (HLA) molecules are a major risk factor for rejection of transplanted organs (in...
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ATP11C promotes the differentiation of pre-B cells into immature B cells but does not affect their IL-7-dependent proliferation
The P4-type ATPases are believed to function as flippases that contribute to the organization of the asymmetric aminophospholipid distribution on the...
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Comparison of Non B-Ig and B-Ig
Immunoglobulin (Ig) has been widely acknowledged to be produced solely by B-lineage cells. However, growing evidence has demonstrated the expression...
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Non B cell-Derived Immunoglobulins The Structure, Characteristics and the Implication on Clinical Medicine
This book has expanded classic concept of immunology. Immunoglobulins have been widely discovered to be produced by many non-B cells. The non B...
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Isolation and Single-Cell Transcriptomic Analysis of Murine Regulatory B Cells
Regulatory B (Breg) cells have been demonstrated to play an important role in the inhibition of a wide range of immunological responses, and they are...
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Characteristics and Clinical Implications of Immunoglobulins Derived from Non B Cells in the Skin
Skin is the most prominent tissue and organ, as well as the first line of defence, of the body. Because it is situated on the body’s surface, it is...
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B-Cell-Activating Factor Contributes to Elevation of the Content of Regulatory B Cells in Neonatal Sepsis
We studied the role of B cell-activating factor (BAFF) in PI3K/AKT/mTOR signaling pathway in promoting proliferation and maintaining survival of...
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Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance
Marginal zone (MZ) B cells, which are splenic innate-like B cells that rapidly secrete antibodies (Abs) against blood-borne pathogens, are composed...
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Reciprocal costimulatory molecules control the activation of mucosal type 3 innate lymphoid cells during engagement with B cells
Innate lymphoid cells (ILCs) are the counterpart of T helper cells in the innate immune system and share multiple phenotypes with T helper cells....
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Investigating the impact of regulatory B cells and regulatory B cell-related genes on bladder cancer progression and immunotherapeutic sensitivity
BackgroundRegulatory B cells (Bregs), a specialized subset of B cells that modulate immune responses and maintain immune tolerance in malignant...
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Dynamic mitochondrial transcription and translation in B cells control germinal center entry and lymphomagenesis
Germinal center (GC) B cells undergo proliferation at very high rates in a hypoxic microenvironment but the cellular processes driving this are...
