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Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration
In neurons, RNA granules are transported along the axon for local translation away from the soma. Recent studies indicate that some of this transport...
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Axonal Degeneration, Impaired Axonal Transport, and Synaptic Dysfunction in Motor Neuron Disorder
Motor neuron diseases (MNDs) are progressive disorders of the neurological system that have a strong effect on upper and lower motor neuron systems....
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Axonal Regeneration Mediated by a Novel Axonal Guidance Pair, Galectin-1 and Secernin-1
Galectin-1 (Gal-1), a member of the Galectin family, is expressed in various tissues and responsible for multiple biological activities. Previous...
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Axonal Transport
Axons are long slender cylindrical projections of neurons that enable these cells to communicate directly with other cells in the body over long...
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The Axonal Actin Filament Cytoskeleton: Structure, Function, and Relevance to Injury and Degeneration
Early investigations of the neuronal actin filament cytoskeleton gave rise to the notion that, although growth cones exhibit high levels of actin...
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Mechanisms of axonal support by oligodendrocyte-derived extracellular vesicles
Extracellular vesicles (EVs) have recently emerged as versatile elements of cell communication in the nervous system, mediating tissue homeostasis....
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Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease
Axonal degeneration determines the clinical outcome of multiple sclerosis and is thought to result from exposure of denuded axons to immune-mediated...
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Combined Catalpol and Tetramethylpyrazine Promote Axonal Plasticity in Alzheimer’s Disease by Inducing Astrocytes to Secrete Exosomes Carrying CDK5 mRNA and Regulating STAT3 Phosphorylation
Alzheimer’s disease (AD) is a common progressive degenerative disease of the central nervous system in aging populations. This study aimed to...
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Axonal energy metabolism, and the effects in aging and neurodegenerative diseases
Human studies consistently identify bioenergetic maladaptations in brains upon aging and neurodegenerative disorders of aging (NDAs), such as...
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Unraveling axonal mechanisms of traumatic brain injury
Axonal swellings (AS) are one of the neuropathological hallmark of axonal injury in several disorders from trauma to neurodegeneration. Current...
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Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons
Our understanding of the biological functions of the tau protein now includes its role as a scaffolding protein involved in signaling regulation,...
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The Transcription Factor Ets1 Influences Axonal Growth via Regulation of Lcn2
Transcription factors are essential for the development and regeneration of the nervous system. The current study investigated key regulatory...
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Mitochondrial Localization of SARM1 in Acrylamide Intoxication Induces Mitophagy and Limits Neuropathy
Sterile α and toll/interleukin 1 receptor motif-containing protein 1 (SARM1) is the defining molecule and central executioner of programmed axon...
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Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein
Pathologic inclusions composed of α-synuclein called Lewy pathology are hallmarks of Parkinson’s Disease (PD). Dominant inherited mutations in...
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Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice
BackgroundAmyloid plaque deposition and axonal degeneration are early events in AD pathogenesis. Aβ disrupts microtubules in presynaptic dystrophic...
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Systemic Inflammation Leads to Changes in the Intracellular Localization of KLK6 in Oligodendrocytes in Spinal Cord White Matter
Axonal injury and demyelination occur in demyelinating diseases, such as multiple sclerosis, and the detachment of myelin from axons precedes its...
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Looking for answers far away from the soma—the (un)known axonal functions of TDP-43, and their contribution to early NMJ disruption in ALS
Axon degeneration and Neuromuscular Junction (NMJ) disruption are key pathologies in the fatal neurodegenerative disease Amyotrophic Lateral...
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Laser-Induced Axotomy of Human iPSC-Derived and Murine Primary Neurons Decreases Somatic Tau and AT8 Tau Phosphorylation: A Single-Cell Approach to Study Effects of Acute Axonal Damage
The microtubule-associated protein Tau is highly enriched in axons of brain neurons where it regulates axonal outgrowth, plasticity, and transport....
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Isotropic Virtual Planes for Measuring Axonal Length: Population and Single Neuron Approaches in Mice and Human Brain
The isotropic virtual planes (IVP) method is a global spatial sampling approach for length estimation. Thanks to computer-assisted microscopy, IVP...
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Upregulated lncARAT in Schwann cells promotes axonal regeneration by recruiting and activating proregenerative macrophages
BackgroundAxonal regeneration following peripheral nerve injury (PNI) depends on the complex interaction between Schwann cells (SCs) and macrophages,...
