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Muscarinic Receptors in Developmental Axonal Competition at the Neuromuscular Junction
In recent years, we have studied by immunohistochemistry, intracellular recording, and western blotting the role of the muscarinic acetylcholine...
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Axonal energy metabolism, and the effects in aging and neurodegenerative diseases
Human studies consistently identify bioenergetic maladaptations in brains upon aging and neurodegenerative disorders of aging (NDAs), such as...
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Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons
Our understanding of the biological functions of the tau protein now includes its role as a scaffolding protein involved in signaling regulation,...
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Synaptic Cooperation and Competition: Two Sides of the Same Coin?
Memories are not recollections of our past but rather predictions of the future. As such, memories are evolving constructs prone to modifications....
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Follicle-innervating Aδ-low threshold mechanoreceptive neurons form receptive fields through homotypic competition
The mammalian somatosensory system is comprised of multiple neuronal populations that form specialized, highly organized sensory endings in the skin....
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Involvement of the Voltage-Gated Calcium Channels L- P/Q- and N-Types in Synapse Elimination During Neuromuscular Junction Development
During the nervous system development, synapses are initially overproduced. In the neuromuscular junction (NMJ) however, competition between several...
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Networking brainstem and basal ganglia circuits for movement
The execution and learning of diverse movements involve neuronal networks distributed throughout the nervous system. The brainstem and basal ganglia...
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A novel small-molecular CCR5 antagonist promotes neural repair after stroke
Chemokine receptor 5 (CCR5) is one of the main co-receptors of HIV-1, and has been found to be a potential therapeutic target for stroke. Maraviroc...
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Neuronal Fractal Dynamics
Synapse formation is a unique biological phenomenon. The molecular biological perspective of this phenomenon is different from the fractal...
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Hybrid Nanoparticles as a Novel Tool for Regulating Psychosine-Induced Neuroinflammation and Demyelination In Vitro and Ex vivo
Polymeric nanoparticles are being extensively investigated as an approach for brain delivery of drugs, especially for their controlled release and...
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Dendritic Spines in Learning and Memory: From First Discoveries to Current Insights
The central nervous system is composed of neural ensembles, and their activity patterns are neural correlates of cognitive functions. Those ensembles...
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Getting to the Bottom of It: Amyloid Beta Peptide Is Derived from a Larger Precursor
The biochemical characterization of the Alzheimer’s disease-associated amyloid beta peptide started the race for the cloning of the gene encoding...
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Blood biomarkers and neurodegeneration in individuals exposed to repetitive head impacts
BackgroundIt is unknown if fluid biomarkers reflective of brain pathologies are useful in detecting and following a neurodegenerative process in...
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Effect of adult-born immature granule cells on pattern separation in the hippocampal dentate gyrus
Young immature granule cells (imGCs) appear via adult neurogenesis in the hippocampal dentate gyrus (DG). In comparison to mature GCs (mGCs) (born...
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Nitroproteomics is instrumental for stratification and targeted treatments of astrocytoma patients: expert recommendations for advanced 3PM approach with improved individual outcomes
Protein tyrosine nitration is a selectively and reversible important post-translational modification, which is closely related to oxidative stress....
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Exploring New Horizons: Synaptic Tagging and Capture Beyond Space and Time
Synaptic tagging and capture (STC) encapsulates how synapses attain persistence in their plasticity through capturing newly synthesized...
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Evolution of the Wilson–Cowan equations
The Wilson–Cowan equations were developed to provide a simplified yet powerful description of neural network dynamics. As such, they embraced...
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Generation of Axons and Dendrites
Neurons, or nerve cells, have the most eye-catching yet diverse morphologies in the body. These morphologies are constructed from axons and dendrites...
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Generation of Axons and Dendrites
Neurons, or nerve cells, have the most eye-catching yet diverse morphologies in the body. These morphologies are constructed from axons and dendrites...