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Correlation analysis between auto-immunological and mutational profiles in myelodysplastic syndromes
Objective and designSystemic-Inflammatory-Autoimmune-Diseases (SIAD) is increasingly considered in Myelodysplastic-Syndromes (MDS). In this line, we...
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No evidence for a pathogen associated with pulmonary MALT lymphoma: a metagenomics investigation
Mucosa-associated lymphoid tissue (MALT) lymphoma is generally associated with chronic antigen stimulation: auto-antigens or of microbial origin....
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Anti-ANX A1 Antibody Therapy in MRL/lpr Murine Model of Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a severe autoimmune disease characterized by dysfunction of immune regulation, overproduction of inflammatory...
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Testicular Immune Privilege: A Recently Discovered Domain of Collectins
Mammalian testis represents an immune privileged site where antigen specific adaptive immunity is suppressed to protect auto-antigenic develo**...
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Immunology of Neuro-Behcet’s Disease (NBD)
A complex genetic background leading to a pro-inflammatory, innate immune system-derived activation perpetuated by adaptive immune responses against...
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Tissue-resident memory T cells break tolerance to renal autoantigens and orchestrate immune-mediated nephritis
Immune-mediated nephritis is a leading cause of acute kidney injury and chronic kidney disease. While the role of B cells and antibodies has been...
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A Pilot Study to Develop Paraneoplastic Cerebellar Degeneration Mouse Model
Modeling paraneoplastic neurological diseases to understand the immune mechanisms leading to neuronal death is a major challenge given the rarity and...
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Immunotherapy for Multiple Myeloma
Multiple myeloma is a clonal disorder of bone marrow plasma cells. Despite the impressive advances in treatment options in the last two decades,...
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Automation Techniques in Immunological Disorders
Immunological disorders are consequences of malfunctioned immune system. These involve the altered functioning of T- and B- cell lymphocytes either...
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Genomic, microbial and environmental standardization in animal experimentation limiting immunological discovery
BackgroundThe use of inbred mice housed under standardized environmental conditions has been critical in identifying immuno-pathological mechanisms...
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The immunology of long COVID
Long COVID is the patient-coined term for the disease entity whereby persistent symptoms ensue in a significant proportion of those who have had...
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Histological Analyses of Arthritic Joints in Collagen-Induced Arthritis Model Mice
Histological analysis is a morphological technique and an effective method for understanding the pathology of rheumatoid arthritis (RA). RA is an...
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Immunoinformatics for the Diagnosis and Monitoring of Autoimmune Diseases
A complicated and diverse set of illnesses known as autoimmune diseases occur when the immune system attacks healthy cells and tissues, causing...
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PD-1/PD-L1 Inhibitors for the Treatment of Lung Cancer
Immune checkpoint inhibitors (ICIs) have gained significant attention and traction in the last few years in the treatment of lung cancer and cancers...
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Pathogenic Role of Fibrinogen in the Neuropathology of Multiple Sclerosis: A Tale of Sorrows and Fears
Multiple sclerosis (MS) is an autoimmune demyelinating neurodegenerative disease of the central nervous system (CNS) due to injury of the myelin...
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CTLA-4 Inhibitors for the Treatment of Lung Cancer
One of the most prevalent malignancies and the main reason for cancer-related deaths globally is lung cancer. The majority of these non-small-cell...
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Reagent Tracker™ Platform Verifies and Provides Audit Trails for the Error-Free Implementation of T-Cell ImmunoSpot® Assays
ELISPOT and FluoroSpot assays, collectively called ImmunoSpot assays, permit to reliable detection of rare antigen-specific T cells in freshly...
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Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity
Most metastatic cancers remain incurable due to the emergence of apoptosis-resistant clones, fuelled by intratumour heterogeneity and tumour...
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Crosstalk Among Glial Cells in the Blood–Brain Barrier Injury After Ischemic Stroke
Blood–brain barrier (BBB) is comprised of brain microvascular endothelial cells (ECs), astrocytes, perivascular microglia, pericytes, neuronal...
